Explore 2 backend python developer jobs from 2 hiring companies in Greencastle, PA, US. Filter by remote, salary, experience, and company, then open any listing to apply.

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Backend Python Developer

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Backend Python Developer Jobs

Axle Informatics

CACI

Hybrid

Onsite

Caci

Job Title: Modeling and Simulation HPC Back End Software DeveloperJob Category: Information TechnologyTime Type: Full timeMinimum Clearance Required to Start: TS/SCI with PolygraphEmployee Type: RegularPercentage of Travel Required: Up to 10%Type of Travel: Local* * * The Opportunity: We are seeking an experienced back-end software developer to support a Modeling and Simulation project that uses High-Performance Computing (HPC) at Ft Detrick, Maryland. Responsibilities:<ul><li>Develop and run simulations on a High-Performance Computing (HPC) System to forecast Chemical and Radiological hazard areas. </li><li>Use modeling and simulation tools to include the Operational Multi-Scale Environment Model with grid Adaptivity (OMEGA). </li><li>Employ a Chemical Hazard Area Modeling Program. </li><li>Switch the existing schedule and resource management from Torque qsub to Slurm batch. </li><li>Support tactical and strategic planning associated with delivery of services and capabilities </li><li>Provide oral and written briefs, presentations, and professional reports to Government senior leaders and decision makers </li><li>Apply proper security measures to safeguard government IT infrastructure </li><li>Develop, update, and maintain documentation </li><li>Develop and review detailed or complex technical documents such as techniques, tactics, and procedures (TTPs), concepts of operations (CONOPS), special instructions and engineering plans. </li><li>Provide continuity and on-the job training to contractor and government technical support personnel.</li></ul> Qualifications: Required: <ul><li>DoD Secret Top Secret Security Clearance with SCI adjudication. </li><li>Be able to complete a Counter-intelligence polygraph </li><li>B.A. in Computer Science, Modeling and Simulations or related field, and 5 or more years’ relevant experience </li><li>Experience with Python, C Shell, and Slurm </li><li>Excellent verbal and written communication skills </li><li>Unix and HPC experience</li></ul> Desired:<ul><li>Experience with Python, C Shell, and Slurm </li><li>EM.S. in Computer Science or related field </li><li>Experience in full stack development </li><li>Security &#43; certification</li></ul>-_________________________________________________________________________What You Can Expect: A culture of integrity.At CACI, we place character and innovation at the center of everything we do. As a valued team member, you’ll be part of a high-performing group dedicated to our customer’s missions and driven by a higher purpose – to ensure the safety of our nation.An environment of trust.CACI values the unique contributions that every employee brings to our company and our customers - every day. You’ll have the autonomy to take the time you need through a unique flexible time off benefit and have access to robust learning resources to make your ambitions a reality.A focus on continuous growth.Together, we will advance our nation&#39;s most critical missions, build on our lengthy track record of business success, and find opportunities to break new ground — in your career and in our legacy. Your potential is limitless. So is ours._________________________________________________________________________Pay Range: There are a host of factors that can influence final salary including, but not limited to, geographic location, Federal Government contract labor categories and contract wage rates, relevant prior work experience, specific skills and competencies, education, and certifications. Our employees value the flexibility at CACI that allows them to balance quality work and their personal lives. We offer competitive compensation, benefits and learning and development opportunities. Our broad and competitive mix of benefits options is designed to support and protect employees and their families. At CACI, you will receive comprehensive benefits such as; healthcare, wellness, financial, retirement, family support, continuing education, and time off benefits.The proposed salary range for this position is: $94,400 - $198,200<div></div><div>CACI is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, pregnancy, sexual orientation, age, national origin, disability, status as a protected veteran, or any other protected characteristic.</div>

Modeling and Simulation HPC Back End Software Developer

TS/SCI with polygraph; BS in Computer Science, Modeling and Simulations or related field; 5+ years’ experience; Python, C Shell, Slurm; Unix/HPC experience; strong communication; ability to brief senior leaders.

<div style="font-size: 10pt; font-family: 'Tahoma';">(ID: 2025-0915) 
Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).
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Benefits We Offer:
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<li style="font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">100% Medical, Dental &amp; Vision Coverage for Employees</li>
<li style="font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Paid Time Off and Paid Holidays</li>
<li style="font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">401K match up to 5%</li>
<li style="font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Educational Benefits for Career Growth</li>
<li style="font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Employee Referral Bonus</li>
<li style="font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Flexible Spending Accounts:
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<li style="font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Healthcare (FSA)</li>
<li style="font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Parking Reimbursement Account (PRK)</li>
<li style="font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Dependent Care Assistant Program (DCAP)</li>
<li style="font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Transportation Reimbursement Account (TRN)</li>
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Overview
Axle is seeking a Scientific Software Engineer that will develop the integration middleware and interactive interfaces for the SOM Center. This position involves building cloud-native applications that establish interoperability between cloud-based AI services, legacy laboratory systems, and real-time experimental state systems, delivering a unified data management interface for scientific discovery data.
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Responsibilities
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<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">API Development:&nbsp;Design and implement high-concurrency asynchronous APIs (using GraphQL or gRPC) to stream data between cloud inference endpoints (e.g., Vertex AI) and centralized state stores.</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">AI-Assisted Development:&nbsp;Actively utilize AI-assisted coding tools (e.g., GitHub Copilot) to accelerate feature implementation, unit testing, and debugging.</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">User Portal &amp; Visualization:&nbsp;Develop the SOM User Portal using modern frameworks to render interactive visualizations. Implement&nbsp;WebGL-based components (e.g., Deck.gl, PixiJS)&nbsp;to render high-density parallel protocol topologies and multi-omics heatmaps without performance degradation.</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Agentic AI Integration:&nbsp;Implement the application logic to support&nbsp;Agent-based workflows, connecting user-facing chat interfaces with backend reasoning engines. Handle complex interaction patterns such as tool execution loops, multi-step reasoning chains, and streaming responses to the user.</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">LIMS Integration &amp; Ontology Enforcement:&nbsp;Develop business logic to integrate modern microservices with Legacy Laboratory Information Management Systems (LIMS). Enforce&nbsp;Ontology Mapping&nbsp;at the user interface level to ensure all data entry adheres to the SOM controlled vocabulary.</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Real-Time State Store:&nbsp;Implement a&nbsp;high-frequency experimental state store&nbsp;using in-memory databases (e.g., Redis), utilizing WebSockets or Server-Sent Events (SSE) to power real-time dashboards that reflect experimental data states.</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Cloud-Native Patterns:&nbsp;Implement Cloud-Native design patterns to reliably consume outputs from asynchronous cloud operations and surface results to the user.</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Collaboration:&nbsp;Collaborate with AI researchers to create explainable interfaces for model predictions.</li>
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Required Qualifications
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<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Bachelor’s or master’s degree in computer science or software engineering with experience in full-stack development for data-intensive applications.</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Proficiency in modern Python backend frameworks (FastAPI, Litestar) and strongly typed frontend ecosystems (React/Next.js with TypeScript).</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Experience with WebGL-based visualization libraries (e.g., Deck.gl, PixiJS, or Plotly) for rendering high-density biological datasets.</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">AI Productivity:&nbsp;Demonstrated ability to leverage AI-driven coding assistants and LLMs to increase development velocity and code quality.</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Experience deploying and debugging applications in Containerized Cloud Environments (Cloud Run, ECS, or Kubernetes).</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Preferred Qualifications</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Familiarity with Agentic AI frameworks (e.g., LangChain, LangGraph, AutoGen) and implementing "Tool Use" patterns in applications.</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Experience with Event-Driven Architectures (Pub/Sub, Kafka) for coordinating hybrid workflows.</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Knowledge of Graph Database query languages (Cypher/Gremlin) and Real-Time/In-Memory databases (Redis).</li>
<li style="line-height: 115%; font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;">Familiarity with integrating applications with Enterprise Identity Providers (OIDC/SAML) and experience working in a biotech or LIMS environment.</li>
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Disclaimer: 
The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.
Accessibility: If you need an accommodation as part of the employment process please contact: <a href="mailto:careers@axleinfo.com" target=" _blank">careers@axleinfo.com</a> 
This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.
</div><div class="content-pay-transparency"><div class="pay-input"><div class="title">Salary Range</div><div class="pay-range">$115,000&mdash;$125,000 USD</div></div></div>

Scientific Software Engineer (Full Stack)

Scientific Software Engineer

Bachelor’s or master’s in computer science or software engineering; full-stack data-intensive apps; Python backend (FastAPI/Litestar); React/TypeScript frontend; WebGL visualizations; containerized cloud deployments.

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