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Python Software Developer Jobs in Southbridge, MA, US

290+ python software developer jobs from 110+ companies hiring in Southbridge, MA, US.

293 jobs- Southbridge • 50 miles
12h
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Applied Scientist, GenAI
Wilmington, Massachusetts, United States
$152k-$189k/yr OnsiteFull Time
TraceLink
TraceLink: Digital supply chain orchestration platform for life sciences and healthcare.
Lead design and deployment of production-grade GenAI and ML systems; hands-on experience with LLM/SLM optimization, multi-agent architectures, and cloud-scale systems.
Python, Cloud Platforms, LLM tooling, Vector databases, CI/CD, Distributed systems, Docker, Kubernetes
1mo
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AV Programmer
Andover, Massachusetts, United States
$105k-$130k/yr OnsiteFull Time
Red Thread
Red Thread: Provides integrated furniture and technology solutions for workplaces.
3+ YOEProven AV Programmer with 3+ years experience; bachelor’s preferred; strong programming skills across languages and frameworks.
C#, NET, Python, JavaScript, Lua, C++, Java, SQL, MongoDB, Flask, Django, Git, Bitbucket
2mo
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Automation Tester with Hammer/Cyara and Conversational AI Testing experience
Hartford, Connecticut, United States
$71k-$113k/yr OnsiteFull Time
Cognizant
CognizantNASDAQ: CTSH: Provides global information technology, consulting, and business process services.
3+ YOE3+ years in QA automation; strong programming fundamentals; experience with Hammer On Demand, Cyara, Selenium; AI testing; CI/CD integration; API and backend testing; GenAI exposure.
Hammer On Demand, Cyara, Selenium, Java, JavaScript, Python, Git, Cucumber, SpecFlow, Windsurf, Cursor, REST, SOAP, AWS, GCP, IBM Cloud
1mo
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Lead AI Solutions Architect - Full Stack
Princeton or Glen Allen or Coppell or Waltham or Philadelphia or Riverwoods or New York City or Chicago or Houston
$129k-$226k/yr HybridFull Time
Wolters Kluwer
Wolters KluwerEuronext Amsterdam: WKL: Provides professional information and software solutions for specialized industries.
10+ YOELeadership-focused AI solutions architect with 10+ years in full-stack engineering, GenAI/Agentic AI, data science, AI/ML, and applied AI engineering; proven leadership and mentoring experience.
Python, FastAPI, Angular, React, LangChain, LlamaIndex, SQL, NoSQL, Azure, AWS
1mo
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Associate
Austin or Bridgewater or Charlotte or Hartford or Phoenix or Raleigh or Richardson
$65k/yr OnsiteFull Time
Infosys
InfosysNYSE: INFY: Provides global IT consulting and digital transformation services.
0+ YOEBachelor’s degree in CS/IT or related field; recent graduates; SDLC training; multiple US locations; no visa sponsorship.
Java, Python, C/C++
1mo
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Cloud Engineering Manager
Marlborough, Massachusetts, United States
$160k-$190k/yr OnsiteFull Time
TASI Measurement
TASI Measurement: Provides industrial measurement instruments and wireless telemetry monitoring solutions.
7+ YOE2+ MgmtLead architecture and delivery of cloud platform; 7+ years software development, 2+ years managing engineers, AWS, Python, MQTT, IoT, and cloud pipelines.
AWS, Python, MQTT, REST APIs, JIRA, Git
3mo
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Data Science Intern - Summer 2026 - Bedford, MA
Bedford, Massachusetts, United States
$40-$50/hr HybridInternship
AspenTech
AspenTech: Provides industrial software for optimizing asset performance and sustainability.
5+ YOEMaster’s in CS/Engineering/OR or related field; 5+ years data analysis and software development; Python, C/C++/C#; ML/AI experience; strong math/statistics; cloud/LLM a plus; US work authorized.
Python, C++, C#, C, Machine Learning, LLM, MLops, Cloud
2w
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Senior Manager, Machine Learning
San Jose or Waltham
$152k-$265k/yr OnsiteFull Time
Adobe
AdobeNASDAQ: ADBE: Provides software for digital media creation and marketing analytics
8+ YOE3+ MgmtEight+ years of software development experience with at least 3 years in management; strong background in generative AI, LLMs, ML model development, and production deployment.
Python, ML Pipelines, MLOps, Cloud Services, Generative AI, LLMs, Claude Code, Cursor AI
1mo
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Associate Director, Biostatistics - Genetic Medicine
Tarrytown or Warren or Cambridge
$176k-$287k/yr OnsiteFull Time
Regeneron
RegeneronNasdaq: REGN: Discovers and manufactures medicines for serious diseases.
6+ YOEPhD or equivalent in statistics/biostatistics with >6 years in pharma OR MS in statistics/biostatistics with >11 years; hematology/IO experience preferred; TTE experience; strong leadership and collaboration skills; proficient in statistical software.
SAS, R, Python
1mo
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Enterprise Data Architect & Integration Lead
Providence, Rhode Island, United States
HybridFull Time
PKF O'Connor Davies
PKF O'Connor Davies: Provides professional accounting, tax, and business advisory services.
10+ YOE5+ Mgmt10+ years in data architecture, software development, or system integration; leadership experience; strong data modeling, API design, and SDLC governance.
Databricks, Snowflake, Microsoft Fabric, REST, GraphQL, SOAP, Webhooks, GitHub, CI/CD, Power Apps, Power Automate, PowerShell, Python, JSON, Node.js, Azure, AWS, Google Cloud

HiringCafe market data

Python Software Developer Jobs market signals in Southbridge, MA, US

These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.

Open jobs
290+
Hiring companies
110+
Fresh sample
20% new in 30d
Salary visibility
90% show pay

Companies appearing in this market

AdobeAspenTechCognizantInfosysPKF O'Connor DaviesRed ThreadRegeneronTASI Measurement

Work location mix in visible results

Onsite: 7Hybrid: 3