Explore 2 lead python developer jobs from 2 hiring companies in Shadyside, OH, US. Filter by remote, salary, experience, and company, then open any listing to apply.

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Lead Python Developer

Wheeling

Moundsville

Bellaire

McMechen

Martins Ferry

Glendale

Steubenville

Weirton

Weirton Heights

Saint Clairsville

Washington

Bethlehem

Upper Saint Clair

Bethel Park

Mount Lebanon

Fairmont

Morgantown

Benwood

Baldwin

Lead Python Developer Jobs

Arcfield

West Virginia University

Onsite

Responsibilities We are seeking a highly experienced Senior Principal Digital Engineer to join our team supporting the modernization of Digital Engineering (DE) and Model-Based Systems Engineering (MBSE) for Naval Nuclear Laboratory (NNL) programs in either the Albany, NY OR the West Mifflin PA area. This role will focus on implementing cutting-edge MBSE processes, advancing Digital Threads, integrating Artificial Intelligence/Machine Learning (AI/ML) methodologies, and modernizing engineering and operational processes across a large organization. The ideal candidate will be a technical leader with deep expertise in systems engineering, hands-on application of digital transformation, and organizational change. Responsibilities The Senior Principal Engineer is expected to bring both technical expertise and leadership to the role, serving as a trusted contributor and advisor within cross-functional teams. The ideal candidate is a self-starter with the initiative to work independently, yet highly collaborative in guiding projects to successful outcomes. This individual demonstrates the ability to analyze complex engineering challenges, develop innovative solutions, and provide technical leadership across system integration, sustainment, safety, and acquisition activities.  Key responsibilities include:<ul><li>Creation and Maintenance of a Digital Thread</li><li>Design, implement, and sustain a cohesive Digital Thread framework to integrate tools, data, and models across system lifecycles.</li><li>Ensure seamless data flow across domains and stakeholders to enable traceability, collaboration, and decision-making.</li><li>Development of Systems Engineering and MBSE Processes</li><li>Establish and refine Model-Based Systems Engineering (MBSE) practices tailored to organizational goals and program needs.</li><li>Develop standardized processes, workflows, and guidelines for implementing systems engineering and MBSE methodologies.</li><li>Orchestrating Organizational Change</li><li>Lead efforts to foster the adoption of Digital Engineering and MBSE practices throughout the organization.</li><li>Provide training, coaching, and ongoing support to teams, bridging gaps in technical knowledge and overcoming resistance to change.</li></ul> Qualities of a Successful Candidate: <ul><li>Self-starter who can work with minimal supervision, navigate at the expert level within systems/digital engineering integration activities.</li><li>Proactive individual who can quickly come up to speed on new technologies and work collaboratively with system domain SMEs, peers, managers, and customers.</li><li>Inquisitive and motivated engineer with strong background in systems/digital engineering principles.</li></ul>Why Join Us?<ul><li>Join a team of world-class MBSE and DE Experts.</li><li>Be part of a dynamic team working on groundbreaking projects.</li><li>Contribute to the development of state-of-the-art systems and make a lasting impact in the industry.</li><li>Exercise considerable latitude in determining objectives and approaches to assignments, giving you the freedom to innovate and excel.</li></ul>If you are a forward-thinking engineer with a passion for innovation and excellence, apply now to become a part of our team! Qualifications REQUIRED SKILLS<ul><li>BS 10-12, MS 8-10, Phd 5-7</li><li>Master’s Degree in technical or scientific field with at least 8 years of recent and relevant Digital Engineering/Systems Engineering experience OR Bachelor’s Degree in technical or scientific field with at least 10 years of recent and relevant Digital Engineering/Systems Engineering experience</li><li>At least 3 years of DoW/DOE experience</li><li>Demonstrated experience in a relevant area of engineering</li><li>Demonstrated understanding of the concept of Digital Threads</li><li>Possess and maintain a DOE-L Clearance or higher OR a DoD/DoW Secret Clearance or higher</li></ul> DESIRED SKILLS Model-Based Systems Engineering (MBSE) Experience:<ul><li>Demonstrated hands-on experience implementing MBSE methodologies in complex systems</li><li>Proficiency with Cameo Systems Modeler, MagicDraw, or similar MBSE environments</li><li>Experience creating and managing SysML/UML models for large-scale engineering projects</li><li>Knowledge of requirements management and traceability within model-based environments</li></ul>Digital Thread Implementation:<ul><li>Practical experience implementing Digital Thread frameworks in engineering organizations</li><li>Hands-on expertise with Syndeia, eQube, or similar Digital Thread tools</li><li>Experience connecting disparate engineering tools and databases into a unified information flow</li><li>Knowledge of configuration management practices for model and data integration</li></ul>Digital Engineering/MBSE Patterns:<ul><li>Understanding of Digital Engineering Strategy principles and implementation frameworks</li><li>Knowledge of MBSE patterns, anti-patterns, and best practices for complex systems</li><li>Experience with digital artifacts management and model validation techniques</li><li>Familiarity with digital transformation roadmaps for large engineering organizations</li></ul>Software Development & Automation:<ul><li>Experience with scripting languages (Python, JavaScript, etc.) for engineering automation</li><li>Knowledge of API integration for connecting engineering tools and platforms</li><li>Experience developing custom plugins or extensions for MBSE tools</li><li>Background in software development methodologies (Agile, DevOps) applied to systems engineering</li><li>Experience with version control systems (Git, SVN) for managing engineering artifacts</li></ul>Advanced Technical Skills:<ul><li>Proficiency with database technologies and query languages for engineering data management</li><li>Experience with cloud platforms for hosting engineering tools and models</li><li>Knowledge of AI/ML integration within engineering workflows and decision support</li><li>Experience with visualization techniques for complex engineering data and relationships</li></ul>Project Implementation Experience:<ul><li>History of successfully implementing MBSE/DE frameworks in large organizations</li><li>Experience developing training programs and materials for digital engineering adoption</li><li>Track record of overcoming organizational resistance to new engineering methodologies</li><li>Experience managing the transition from document-based to model-based processes</li></ul>Domain Knowledge:<ul><li>Familiarity with Naval Nuclear Laboratory programs, systems, or similar complex domains</li><li>Understanding of systems engineering processes in regulated environments Experience with Department of Energy (DOE) or Department of Defense (DoD) programs</li></ul> Equal Pay Act This is the projected compensation range for this position. There are differentiating factors that can impact a final salary/hourly rate, including, but not limited to, Contract Wage Determination, relevant work experience, skills and competencies that align to the specified role, geographic location (For Remote Opportunities), education and certifications as well as Federal Government Contract Labor categories. In addition, Arcfield invests in its employees beyond just compensation. Arcfield ’s benefits offerings include, dependent upon position, Health Insurance, Life Insurance, Paid Time Off, Holiday Pay, Short Term and Long-Term Disability, Retirement and Savings, Learning and Development opportunities, wellness programs as well as other optional benefit elections.
						
Min: $128,317.13
Max: $234,861.67 EEO Statement 
								We are an equal opportunity employer and federal government contractor. We do not discriminate against any employee or applicant for employment as protected by law.

Senior Principal Digital Engineer

Senior-level Digital Engineering/MBSE expert with DoD/DOE experience, MBSE tools proficiency, and the ability to lead digital thread initiatives.

%3Cp%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3EThe Rockefeller Neuroscience Institute Department of Neuroscience at West Virginia University is currently accepting applications for a Post Doctoral Fellow.%26nbsp;%3C/span%3E%3C/p%3E%3Cp%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E%3Cstrong%3EAbout the Opportunity%3C/strong%3E%3C/span%3E%3C/p%3E%3Cp%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3EPostdoctoral fellowship in synaptic biology and super-resolution imaging in models of Alzheimer’s disease. %3C/span%3E%3Ca href=%22https://The Hruska Laboratory%22%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3EThe Hruska Laboratory%3C/span%3E%3C/a%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E in the Department of Neuroscience at the West Virginia University School of Medicine is recruiting a postdoctoral researcher to join an exciting, fully funded program supported by the National Institute on Aging (NIA). This position offers an outstanding opportunity to lead a high-impact project investigating the molecular architecture of synapses using advanced approaches, including STED super-resolution microscopy.%3C/span%3E%3C/p%3E%3Cp%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3EOur work seeks to uncover core mechanisms that govern synapse function and plasticity, with a particular focus on nanoscale organization of dendritic spines. We aim to understand how these highly organized molecular structures become disrupted in Alzheimer’s disease (AD), and how these structural changes translate into synaptic dysfunction, reduced plasticity, circuit instability, and ultimately cognitive decline and memory impairment. Our recent findings reveal striking synapse-specific vulnerability to amyloid-beta (Aβ), suggesting the existence of an underlying molecular logic that remains to be defined. To uncover these mechanisms, we integrate molecular biology, biochemistry, CRISPR-based genome engineering, and advanced imaging in living and fixed neurons, directly linking nanoscale synaptic organization to functional outcomes.%3C/span%3E%3C/p%3E%3Cp%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3EWe are seeking a highly motivated, intellectually curious, and creative scientist who is eager to lead an ambitious project. The successful candidate will hold a Ph.D. in neuroscience or molecular and cellular neurobiology, have at least one first-author publication in a peer-reviewed international journal, and possess strong expertise in molecular and cellular neuroscience. Candidates who are about to complete their Ph.D. are encouraged to apply. The ideal applicant is independent, rigorous, and excited to build a research program that connects molecular, cellular, and circuit-level neuroscience.%3C/span%3E%3C/p%3E%3Cp%3E%3Ca href=%22https://Department of neuroscience%22%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3EDepartment of neuroscience%3C/span%3E%3C/a%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E offers a highly collaborative, intellectually vibrant, and deeply supportive scientific environment, with access to %3C/span%3E%3Ca href=%22https://state-of-the-art infrastructure%22%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3Estate-of-the-art infrastructure%3C/span%3E%3C/a%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E. Hruska laboratory is committed to mentorship, career development, and fostering scientific independence. This position is fully funded, ensuring long-term stability and continuity for the project. At the same time, we actively encourage and support the successful candidate in applying for competitive fellowships, as part of their professional growth and transition toward research independence.%3C/span%3E%3C/p%3E%3Cp%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3EFor details about the position, please reach out directly to Dr. Martin Hruska (martin.hruska@hsc.wvu.edu).%3C/span%3E%3C/p%3E%3Cp%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3EWe strongly believe in work-life balance and keeping time for things we love outside our work. WVU offers generous benefits, including:%3C/span%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;37.5-hour work week%26nbsp;%3C/span%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;13 paid holidays (%3C/span%3E%3Ca href=%22https://talentandculture.wvu.edu/benefits-and-compensation/holiday-schedule%22%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3Estaff holiday calendar%3C/span%3E%3C/a%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E)%3C/span%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;24 annual leave (vacation) days per year (%3C/span%3E%3Ca href=%22https://talentandculture.wvu.edu/benefits-and-compensation/time-off/ee-leave%22%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3Eemployee leave%3C/span%3E%3C/a%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E)%3C/span%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;18 sick days per year (for when you’re ill, for when you need time to care for sick family, for your own, or your family’s, regularly scheduled medical appointments. Who is family for the purpose of this leave? A lot of people in your life including immediate relatives and in-laws as well as others considered to be members of your household living under the same roof)%3C/span%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;WVU offers a range of %3C/span%3E%3Ca href=%22https://talentandculture.wvu.edu/benefits-and-compensation/insurance-plans%22%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3Ehealth insurance and other benefits%3C/span%3E%3C/a%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;401(a) retirement savings with 6% employee contribution match, eligibility to continue health insurance, and other retiree perks. Looking for %3C/span%3E%3Ca href=%22https://talentandculture.wvu.edu/benefits-and-compensation/retirement%22%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3Emore retirement benefits information%3C/span%3E%3C/a%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E? Check out retirement health insurance benefits, retirement income, and FAQ’s.%3C/span%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Wellness programs%3C/span%3E%3C/p%3E%3Cp%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E%3Cstrong%3EWhat You%27ll Do%3C/strong%3E%3C/span%3E%3C/p%3E%3Cp%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Design, plan, and execute experiments using advanced imaging techniques (e.g., confocal, STED).%3C/span%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Prepare and process biological samples for imaging (e.g., tissue sections, cell cultures).%3C/span%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Perform image acquisition, processing, and quantitative analysis using specialized software.%3C/span%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Manipulate and analyze protein or RNA expression using molecular tools to test hypotheses%3C/span%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Collaborate with lab members to interpret data and troubleshoot experiments.%3C/span%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Contribute to manuscript writing, grant preparation, and presentation of results.%3C/span%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Maintain detailed and organized records of experimental procedures and results.%3C/span%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Present findings at national and international conferences%3C/span%3E%3Cbr%3E%3Cspan style=%22font-family:Arial, Helvetica, sans-serif;font-size:14px;%22%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Maintain high standards of laboratory organization, rigor, reproducibility, and academic integrity%3C/span%3E%3C/p%3E%3Cp%3E%26nbsp;%3C/p%3E 
<ul><li>Ph.D. in neuroscience, molecular biology, biochemistry or a related field.  </li><li>Experience working with molecular cloning/engineering of DNA constructs.</li><li>To be considered for this position, applicants should submit a cover letter of interest addressing qualifications for the position as well as current CV/resume. </li><li>All qualifications must be met by the time of employment.</li></ul>Knowledge, Skills and Abilities<ul><li>Confocal microscopy (understanding of super-resolution modalities strongly preferred)</li><li>Ability to work independently – including designing experiments, analyze data, and write manuscripts  </li></ul>Preferred Qualifications<ul><li>Culturing/transfecting primary cortical and/or hippocampal neurons</li><li>Experience with neurodegenerative disease models</li><li>CRISPR-based genome engineering</li><li>Coding skills (e.g., Java, Python)  </li></ul> 
*!Required Certifications (may be completed after hire): •    CITI Biohazards training certificate •    CITI animal training certificate •    CITI Conflict of Interest in Research certificate   
*!West Virginia University is a place of purpose and community. We take pride in our profound impact on the state of West Virginia and are committed to the personal and professional growth of our employees.From the groundbreaking R1 research at our flagship campus in Morgantown to the career-oriented programs at WVU Potomac State in Keyser, and the technology-intensive programs at WVU Tech in Beckley, the contributions of WVU employees resonate across the state, touching lives and shaping futures.At WVU, you will discover a supportive community that champions work-life balance and fosters a collaborative atmosphere. Our core values — service, curiosity, respect, accountability and appreciation — unite us as Mountaineers.Join us at West Virginia University, where your work will make a lasting impact. To learn more about WVU, visit wvu.edu.West Virginia University is an Equal Opportunity Employer. We invite all qualified applicants regardless of race, color, religion, sex, national origin, age, disability, genetic information, or Veteran status.

Post Doctoral Fellow - Rockefeller Neuroscience Institute Department of Neuroscience

Post Doctoral Fellow

Ph.D. in neuroscience or molecular/cellular neurobiology; at least one first-author publication; strong expertise in molecular/cellular neuroscience; independent, rigorous, and capable of leading a project; experience with advanced imaging and data analysis.

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