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Python Developer Jobs in Reading, PA, US
620+ python developer jobs from 200+ companies hiring in Reading, PA, US.
3w
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AVP, Quantitative Modeler
Wilmington, Delaware, United States
HybridFull Time
Design and implement mathematical, statistical, and machine learning models; develop analytics; use Python/SAS; build IFRS 9 models; document and validate models.
Python, SAS, Statistical Modeling, Machine Learning
3w
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Bioinformatics Analyst - Auslander Lab
Philadelphia, Pennsylvania, United States
OnsiteFull Time
10+ YOEPhD in Biostatistics, Computational Biology, Bioinformatics, or related field; 10+ years Linux/Unix experience; strong Python and R skills; data visualization and large-scale data processing; experience building bioinformatics tools; strong publication record; domain expertise in cancer biology, microbiome, and computational genomics.
Python, R, Linux, Snakemake, Nextflow, Cloud Computing, High-Performance Computing, Git
1w
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Quantitative Analytics & Model Consultant Senior - Data Model Analytics
Pittsburgh or Philadelphia or Cleveland or Wilmington or Houston
$80k-$185k/yr OnsiteFull Time
6+ YOE6+ years in quantitative analytics, modeling, or risk management; strong Python and PySpark; experience with large data; CRE experience preferred; model development and documentation skills.
Python, PySpark, Distributed Computing
2w
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Lead Analyst, Collections Analytics
Wilmington, Delaware, United States
HybridFull Time
4+ YOEBachelor’s or Master’s in a quantitative field; 4+ years in analytics or software development in financial services; Python and SQL proficiency; Power BI; experience with large datasets and governance; Git familiarity.
Python, SQL, Power BI, Git, Object-Oriented Programming
9h
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Senior Associate, National Security-Cyber Security Governance
Philadelphia, Pennsylvania, United States
$80k-$110k/yr OnsiteFull Time
3+ YOE3+ years in AI/ML development or security; 2+ years in information security; hands-on with AI/ML frameworks; proficiency in Python; cloud AI platform experience; knowledge of AI compliance frameworks.
Python, TensorFlow, PyTorch, scikit-learn, Hugging Face, Docker, Kubernetes, Terraform, MLflow, Kubeflow, SageMaker, Azure ML, Vertex AI, Evidently AI, Fiddler AI, WhyLabs, Neptune.ai, Guardrails AI, LangChain, LlamaIndex, SHAP, LIME, Fairlearn, AIF360, PySyft, TensorFlow Privacy, Opacus, Docker, Kubernetes
1mo
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DevSecOps Architect – Toolchain Support & Consulting
Little Falls or Santa Clara
$128k-$239k/yr OnsiteFull Time
8+ YOE8+ years in DevSecOps with end-to-end software delivery, CI/CD, SCM, cloud/on-prem, and security tooling.
GitHub, Bitbucket, Azure DevOps, SonarQube, Checkmarx, Veracode, Snyk, Mend.io, Black Duck, GitLeaks, Dependabot, Terraform, Ansible, Docker, Kubernetes, Jenkins, GitHub Actions, Bash, Python, PowerShell, Groovy, YAML
1mo
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Lead AI Solutions Architect - Full Stack
Princeton or Glen Allen or Coppell or Waltham or Philadelphia or Riverwoods or New York City or Chicago or Houston
$129k-$226k/yr HybridFull Time
10+ YOELeadership-focused AI solutions architect with 10+ years in full-stack engineering, GenAI/Agentic AI, data science, AI/ML, and applied AI engineering; proven leadership and mentoring experience.
Python, FastAPI, Angular, React, LangChain, LlamaIndex, SQL, NoSQL, Azure, AWS
3d
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2026 Summer Intern - Tech
New York or Austin or King of Prussia
$40/hr HybridInternship
Rising or recent graduates; hybrid in New York City, Austin, or King of Prussia; backend language proficiency; SDLC understanding; Git; strong analytical and communication skills; collaborative mindset.
Python, TypeScript, Git, LangChain, OpenAI APIs, AWS, GCP, Azure, Asana, Jira, Notion, Monday.com, Salesforce, HubSpot
2w
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Director, AI and Digital Health
Plymouth Meeting, Pennsylvania, United States
$147k-$184k/yr RemoteFull Time
10+ YOE3+ Mgmt10+ years in software/health tech evaluation and leadership; 3+ years in people management; SaMD, EHR interoperability, cybersecurity, and client-facing testing.
Python, LLMs, AI software, Microsoft Office 365, Windows
1mo
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Associate R&D Scientist in Applications Technology
Newark, Delaware, United States
$79k-$132k/yr HybridFull Time
2+ YOEBachelor’s degree in engineering or related field with 2 years in R&D; or Master’s with 0 year and 2 years of experience in chemical/agriculture R&D; experience in lab automation, imaging, chemistry/formulation, and design.
Python, Matlab, Creo, SolidWorks, AutoCAD, Hyperspectral imaging, Multispectral imaging, PLC, Microcontroller, 3D printing
2mo
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Postdoctoral Research Associate in Evolutionary Genomics & Molecular Evolution
Bethlehem, Pennsylvania, United States
$62k/yr OnsiteFull Time
PhD in Bioinformatics, Biological Sciences, or closely related field; strong programming/bioinformatics, writing, sequencing, and cross-species comparative biology skills.
Python, R, Linux, Bioinformatics tools
4w
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Clean Energy and Technologies Project Leader
Newark, Delaware, United States
OnsiteFull Time
2+ YOEMaster’s degree in Management; 2 years in energy markets/systems and advanced analytics; 15% domestic/international travel.
Python
1w
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NERA Consultant - Antitrust/Labor Economist (Job Market/New PhD)
Los Angeles or New York or Chicago or Washington
$225k-$235k/yr HybridFull Time
PhD in Economics with training in Labor Economics or IO, econometrics; strong written/oral communication; capable of high-level economic research.
Stata, R, Python, Excel
1d
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Associate Director, Safety Surveillance Research Scientist
New York City or La Jolla or Kirkland or Bothell or Collegeville or Stockholm or Cambridge or Groton
$139k-$232k/yr HybridFull Time
6+ YOEBA/BS with 6+ years or MBA/MS with 5+ years or PhD/JD with 1+ year or MD/DVM with any years; epidemiology and literature review skills; statistical computing; vendor management; regulatory engagement.
SAS, R, Python, SQL, AI tools
4d
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Data Scientist
Denver or Washington or Boston or Woodlawn or Philadelphia
$82k-$133k/yr HybridFull Time
1+ YOEExperience with healthcare data analysis using R/SAS/SPSS; develop reports and dashboards; communicate results clearly.
SAS, R, SPSS, STATA, Python
1mo
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IT Manager, Data Management, Analysis, Reporting & Development
Fairless Hills or Hatboro
OnsiteFull Time
7+ YOE3+ MgmtLeads enterprise data strategy, governance, data lake, analytics, BI and AI development; manages team; 7+ years data analytics/BI; 3+ years leadership; data lakes and ERP experience; SQL and data modeling; AI/ML experience preferred.
SQL, Data Modeling, ERP, Data Lake, BI, AI/ML, Python
5d
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Data, Analytics & AI Team Lead
Atlanta or Houston or King of Prussia
HybridFull Time
10+ YOE5+ Mgmt10+ years in data analytics/engineering and AI with leadership and business development experience; strong stakeholder management and proposal skills.
Python, SQL, Cloud platforms, Power BI, Databricks, Snowflake
2mo
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Application Integration Specialist
Lancaster or Allentown or Chambersburg or Reading or York or Mechanicsburg or Exton
$75k-$85k/yr HybridFull Time
3+ YOEDesign, develop, and maintain secure application integrations using APIs, AI, and automation; collaborate with stakeholders; ensure security; document and upgrade systems.
PowerShell, Power Automate, APIs, Azure OpenAI, Private AI, Power BI, Python, SQL, Smartsheet
2mo
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AI Platform Architect
Philadelphia or Iselin or New York
$120k-$200k/yr OnsiteFull Time
8+ YOE8+ years cloud platform architecture or AI/ML platform development; 5+ years Azure services; 3+ years benchmarking LLMs; bachelor's degree.
Azure, Cosmos DB, ADLS, Purview, Azure OpenAI, Power BI, Grafana, Python, TypeScript, SQL, Terraform, Bicep
1mo
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Model Execution Specialist
Chadds Ford or Columbus or Plano or Draper or New York or Wilmington
$98k-$222k/yr HybridFull Time
5+ YOEBachelor’s degree in finance, statistics, economics, or related field; 5+ years model development/execution/analysis in finance; strong CECL and stress testing knowledge.
Python, Hyperion Essbase, Microsoft Excel, Advanced SQL
3mo
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Computer Science Faculty
Bethlehem, Pennsylvania, United States
OnsiteFull Time
Full-time, tenure-track faculty position. Teaching computer science courses; advisory duties; participate in service and professional development. Strong classroom technology and collaboration skills required.
C++, Python, PHP, JavaScript, SQL, Object Oriented Programming, assembly language, data structures, algorithm analysis
4d
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eBusiness & Integration Architect
Wayne, Pennsylvania, United States
HybridFull Time
5+ YOEBachelor's degree; 5-8+ years cross-system interface development and EDI; SAP tech stack experience; API/EDI, sFTP; cloud EDI platforms; SDLC; strong communication.
SAP BTP Integration Suite, SAP PO, SAP BTP CPI, sFTP, Elemica, Seeburger, Boomi, trueCommerce, goAnywhere, ANSI X12, EDIFACT, cXML, XML, xCBL, iDoc, BPMN, API Management, JavaScript, Python, Groovy, AI integration
6d
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Senior Analyst, Data Engineering
Philadelphia, Pennsylvania, United States
$73k-$101k/yr HybridFull Time
3+ YOEBachelor's degree in CIS/IT/Business/Marketing; 3+ years IT systems analysis; SQL expertise; MS Office (Visio); software development/support experience; API/REST knowledge; data warehousing; NoSQL experience a plus.
SQL, SQL Server, SSIS, Visual Studio, Java, R, Perl, Python, AWS, Azure, Google, NoSQL, MongoDB, Hadoop, Hive, Spark, Presto, Pig
2mo
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Manager, Transmission Strategy (PJM)
Philadelphia, Pennsylvania, United States
HybridFull Time
5+ YOEBS in Electrical Engineering; 5 years in renewable/traditional energy development or transmission planning; proficiency in power flow software (TARA, PSS/E); knowledge of PJM RTEP and generator interconnection studies; ability to automate interconnection studies.
PSS/E, TARA, Python
1mo
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Summer Camp Coding, Digital Arts, or Game Development Assistant Teacher
Ambler, Pennsylvania, United States
$13-$14/hr OnsiteMultiple Commitments Available
0+ YOEEntry level seasonal role teaching and assisting in summer tech education programs; no formal experience required.
Python, Javascript, Lua, Roblox, App Design, Digital Arts, Video Editing, 3D Modeling, Robotics, Minecraft
HiringCafe market data
Python Developer Jobs market signals in Reading, PA, US
These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.
Open jobs
620+
Hiring companies
200+
Fresh sample
61% new in 30d
Salary visibility
55% show pay
Companies appearing in this market
BarclaysThe Wistar InstituteBlack RocketOneMain FinancialPNC Financial ServicesAESAgilent TechnologiesAir Liquide
Work location mix in visible results
Hybrid: 17Onsite: 15Remote: 1