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Python Developer Jobs in Temecula, CA, US
580+ python developer jobs from 190+ companies hiring in Temecula, CA, US.
1mo
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Site Reliability Engineer II
Austin or Irvine or Akron
$99k-$138k/yr HybridFull Time
2+ YOE2–4 years in site reliability, DevOps, or cloud operations; strong Linux; cloud platforms (Azure/AWS); IaC (Terraform/Ansible); CI/CD; monitoring; scripting.
Terraform, Ansible, CloudFormation, Prometheus, Grafana, ELK, Site24x7, Nagios, Python, Bash, PowerShell, GitLab, Kubernetes, AKS, EKS, S3, Blob Storage
23h
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Firewall Security Networking Engineer
Chicago or San Francisco or Los Angeles or San Diego or Seattle
$120k-$140k/yr HybridFull Time
5+ YOEBachelor’s degree in CS/EE/CE or related field; firewall expertise (Palo Alto, Check Point); network design and troubleshooting; strong communication.
Palo Alto Firewall, Check Point Firewall, Panorama, Prisma, StrataCloud, tcpdump, Wireshark, Python, Ansible, Terraform, AWS, GCP, Azure
2mo
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Partner Support Escalation Engineer (Contract)
Carlsbad or United States
$95k-$115k/yr RemoteFull Time
3+ YOE3+ years in partner engineering or technical support; IoT device troubleshooting; cloud platforms (AWS/GCP/Azure); networking; mobile apps; log analysis; Jira/Salesforce.
AWS, GCP, Azure, Splunk, Datadog, CloudWatch, Jira, Confluence, Salesforce, Wi-Fi, NAT, DNS, firewalls, REST APIs, Webhooks, OAuth, Python, Bash
1mo
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Principal R&D Design Engineer
Irvine, California, United States
$118k-$167k/yr OnsiteFull Time
6+ YOEBachelor/Master/PhD in engineering with relevant experience; FE modeling and software; CAD; nonlinear mechanics and fatigue.
SolidWorks, Creo, ABAQUS, LS-DYNA, Python, MATLAB, FE modeling
1mo
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Analog Design Engineer for PLL/Adaptive Clocking
San Diego, California, United States
$122k-$209k/yr OnsiteFull Time
Mixed-signal circuit design in FinFET PLLs; VCO, charge pump, dividers, LDO, bandgap; analog CAD tools; scripting; mentoring.
Cadence ADE-L, Cadence ADE-XL, Spectre, HSPICE, MATLAB, SystemVerilog, Python, Perl
2mo
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Sr Embedded Software Test Engineer I
Orange County, California, United States
$115k-$149k/yr HybridFull Time
5+ YOE5+ years software QA; 3-4 years testing desktop/embedded systems; QA in regulated environments; experience with electronic test equipment; strong QA processes; problem solving; able to work independently or in teams.
Linux, Python, C/C++, C#, .NET, MySQL, Test-Driven Development, JUnit
1w
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Senior Cybersecurity & Network Security Engineer
Laguna Hills, California, United States
$115k-$135k/yr OnsiteFull Time
5+ YOELead security strategies; 5–10+ years in cybersecurity; healthcare regulatory experience (HIPAA/PHI preferred).
Google Workspace Admin, Bitdefender, NinjaOne, AWS, Azure, GCP, Python, PowerShell, SAST, DAST, EDR, XDR, SIEM
4w
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Senior Systems and Test Engineer
Escondido, California, United States
$137k-$156k/yr OnsiteFull Time
7+ YOE7+ years Systems/Electrical/Computer engineering experience; BS in related field; strong Linux, scripting, test and design verification skills.
Linux, Python, Bash, SolidWorks, Allegro, NVMe, PCIe
3w
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Manager Procurement Principal Cost Engineer
West Chester or Cincinnati or Raritan or Irvine
$102k-$177k/yr HybridFull Time
10+ YOE10+ years in electronics cost engineering with EMS experience; bachelor's degree required; strong cost modeling and negotiation skills.
Microsoft Excel, PLM, ERP, BOM management, EDA tools, SQL, Python, Tableau, Power BI
3mo
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Software Engineering Intern
Rancho Cucamonga, California, United States
$20-$22/hr OnsiteInternship
2+ YOEPursuing a technical BS with 2+ years completed; strong coding skills; git proficiency; knowledge of data structures and OS principles; experience in C/C++/Rust or Python/MATLAB; able to develop executable Python packages and work in a team.
C++, Rust, C, Python, Matlab, Git, Linux
2mo
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Distribution Automation Engineer 3 (Santa Ana, CA, US, 92705)
Santa Ana, California, United States
HybridFull Time
5+ YOEBachelor's degree in engineering or related field; 5+ years engineering experience in operations/production; valid driver's license.
VBA, SQL, Python, DMS/SCADA, EMS, CYME, Power Apps, Excel
1w
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ASIC/FPGA Verification Engineer - (Associate, Experienced, or Lead) - SoCal
El Segundo or Huntington Beach
OnsiteFull Time
5+ YOEBachelor's degree in engineering or related field; experience in ASIC/FPGA verification; SystemVerilog/UVM; HDL proficiency; testbenches, coverage models, and regression testing experience.
SystemVerilog, UVM, HDL, Verilog, Python, Make, Perl, Git, SV Assertions
2w
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Senior Computational Chemist
Cambridge or La Jolla
$106k-$177k/yr HybridFull Time
PhD in computational chemistry or related field; strong cheminformatics; Python, RDKit; ML experience; data pipeline and software development skills.
Python, RDKit, NumPy, Pandas, SQL, Rest API, GitHub, SLURM, AWS, GCP
1mo
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Algorithm Intern
La Jolla, California, United States
$22-$25/hr HybridFull Time
0+ YOEPhD student with hands-on deep learning/model development in medical imaging; proficient in Python and DL frameworks; strong communication and collaboration skills.
Python, PyTorch, TensorFlow
1mo
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Data Scientist for Analytics (Engineer/Scientist Support)
Norco, California, United States
$70k-$143k/yr OnsiteFull Time
Bachelor’s degree; U.S. citizen; DoD SECRET clearance; on-site in Norco, CA; willingness to travel occasionally; proficient in MATLAB or Python; strong analytical and communication skills.
MATLAB, Python
3w
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MU-Data Engineers II
Costa Mesa, California, United States
$129k-$130k/yr RemoteFull Time
2+ YOEBachelor's degree in computer science or related field and 2+ years data engineering experience with SQL and Python; experience with ETL, data pipelines, and AWS; knowledge of data warehousing and analytics tools.
SQL, Python, AWS (Lambda, S3, Glue, Redshift), Snowflake, Terraform, Bitbucket, Airflow, Jenkins, Tableau, Tealium, GA360, Braze
1w
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AI/ML Applied Data Scientist - Generative AI (Newport Beach, CA, US, 92660)
Newport Beach, California, United States
$90k-$199k/yr HybridFull Time
3+ YOE3+ years in data science; at least 1 year with LLMs and agents in production; strong Python and ML tooling.
Python, PyTorch, LangGraph, Langfuse, MLFlow, Weights & Biases, PEFT (LoRA, QLoRA), vLLM, TensorRT-LLM
3w
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AI Agent Builder
Carlsbad or Scottsdale or Austin or Charlotte or Chicago
RemoteFull Time
5+ years Python/JSON/JavaScript; experience with AI platforms and APIs; web and data skills; knowledge of MarTech is a plus.
Python, JSON, JavaScript, APIs, Webhooks, HTML, CSS, SQL, Firebase, Power Automate, Copilot, Claude, Codex, n8n
3w
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Senior Technical Artist: Procedural Art
Carlsbad or Leeds or Oakville
$105k-$140k/yr OnsiteFull Time
5+ YOE5+ years as Technical Artist/Tools Programmer; expert in photogrammetry workflows; Python; build systems; DCC tools; ML pipelines.
Houdini, Zbrush, Agisoft, Metashape, Python, Jenkins, Airflow, Celery
4w
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R&D Associate - Consumable Development
Irvine, California, United States
$62k-$65k/yr OnsiteFull Time
DOE experience; SolidWorks CAD; wet-lab hands-on; data analysis (Python/JMP); cross-functional collaboration.
SolidWorks, CAD, Python, JMP, 3D printing, CNC machining
3w
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Sr. Professional, Software Engineering
Irvine or Dallas
$130k-$160k/yr RemoteFull Time
8+ YOE8+ years software engineering; strong Snowflake, Databricks, Python, SQL; cloud platforms; large-scale production systems; mentoring; AI/ML data capabilities.
Snowflake, Databricks, Apache Spark, Python, SQL, Cloud Platforms, Airflow, Dagster, Terraform, Tableau, Looker, Kafka, Pub/Sub
3w
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Data Scientist II
Irvine or Remote
$83k-$127k/yr HybridFull Time
2+ YOE2–5+ years of data science experience; Bachelor's in CS/DS/Engineering/Math; production ML deployment; cloud platforms (Azure/AWS); Python and SQL; strong communication.
Python, SQL, Azure Machine Learning, AWS, SageMaker, LLMs, NLP
5d
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Simulation Platform Partner Product Owner, Architect
Lake Forest or Houston or Philadelphia
$142k-$271k/yr HybridFull Time
7+ YOE7+ years in process industry; MS in Chemical Engineering; domain expert in chemical process simulation; experience with AVEVA Process Simulation or similar; Python coding ability; agile experience.
Python, C#, C++
1mo
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Software Intern
Irvine, California, United States
$25-$40/hr HybridFull Time, Internship
2+ YOEUndergraduate student (rising senior in Summer 2026) pursuing CS/CE/Math or related field; strong communicator; experience with Python/JavaScript/C#/C++; REST APIs; JSON; cloud basics; excellent interpersonal skills.
Python, JavaScript, C#, C++, REST, JSON, AWS, GCP, Azure, Google Workspace
2mo
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Agentic AI Architect
Irvine, California, United States
$159k-$270k/yr OnsiteFull Time
10+ YOE10+ years software engineering and AI/ML systems; 5-7 years in architecting distributed AI systems; deep agentic AI, LLMs; Python and ML libraries; software architecture; MLOps/LLMOps; data engineering and cloud platforms.
Python, TensorFlow, PyTorch, scikit-learn, Hugging Face Transformers, LangChain, AutoGen, CrewAI, LlamaIndex, Google Vertex AI, Microsoft Semantic Kernel, APIs, microservices, MLOps, LLMOps, data pipelines, vector databases, knowledge graphs, cloud platforms
3w
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Product Development Scientist
Irvine, California, United States
$77k-$120k/yr OnsiteFull Time
3+ YOEMaster’s with 3+ years or PhD with 1+ year; expertise in NGS, PCR-based assays; molecular biology (PCR/MSP), DNA extraction; FDA QSR/ISO knowledge; data analysis with R/Python; strong communication.
NGS, PCR, MSP, DNA extraction, R, Python
1mo
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Research Scientist
Costa Mesa, California, United States
$125k-$150k/yr HybridFull Time
5+ YOEPhD in neuroscience or related quantitative field; experience with neuroimaging research and machine learning; proficient in Python/MATLAB/R; familiarity with SPM, FSL, AFNI or Nilearn.
Python, MATLAB, R, SPM, FSL, AFNI, Nilearn
2w
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Principal Scientist, Computational Pathobiologist
Spring House or La Jolla
$117k-$201k/yr HybridFull Time
6+ YOE6+ years data science/biostatistics for multimodal biomedical data; Python and/or R; cloud deployment; AI/ML; data visualization; understanding of biomedical context.
Python, R, GCP, Azure, AWS, Snowflake, Posit Connect, Spotfire, Power BI, R Shiny, AI, Machine Learning, AlphaFold
1mo
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Quantitative Research Analyst - Client Solutions & Analytics
Newport Beach, California, United States
$205k-$230k/yr OnsiteFull Time
1+ YOE1-3 years asset management or research experience; PhD desirable; strong quantitative background; programming in Python/MATLAB/C++; strong analytical and presentation skills.
Python, MATLAB, C++
1mo
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Research Associate
Newport Beach, California, United States
$80k-$110k/yr HybridFull Time
1+ YOEBachelor’s degree in finance/real estate/economics; 1-3 years in financial research; strong financial modeling and Excel; CFA interest; SQL/Python a plus.
SQL, Python, Microsoft Excel
1mo
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Quality Analyst
Orange, California, United States
$80k-$95k/yr HybridFull Time
3+ YOEData-driven healthcare analytics with SQL/Python; develops dashboards; supports performance improvement in value-based care.
SQL, Python, Tableau, Power BI, Excel, Databricks
5d
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Senior Scientist II/Principal Research Scientist I - Translational Program Science
Irvine, California, United States
$110k-$209k/yr OnsiteFull Time
4+ YOEPhD with 4+ years, or Master’s with 10+ years, or Bachelor’s with 12+ years; ophthalmology experience; programming in Python or R; in vivo preclinical experience; cross-functional collaboration; strong scientific communication.
Python, R, Computational Biology
2d
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Business Intelligence - Senior Programmer
Minneapolis or Charlotte or Irvine or Cincinnati or Owensboro or Owensboro
$105k-$124k/yr HybridFull Time
6+ YOEBachelor’s degree or equivalent; 6+ years in development; strong SQL, Python/C#, Power Platform, Tableau/Power BI; ETL/ELT; Azure; APIs; hybrid schedule.
SQL, Python, C#, Power Platform, Tableau, Power BI, ETL/ELT, Azure, APIs
3w
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Student Assistant - CA DMV Customer Services Division- Information Technology - Hybrid
Sacramento or Fresno or Riverside
$17-$21/hr HybridPart Time, Temporary
College student; basic web development and data analysis knowledge; HTML/CSS/JavaScript; Python; NLP interest; bilingual in Spanish and English; willing to work in a hybrid schedule.
HTML, CSS, JavaScript, Python, Jupyter, LangChain, Bedrock, Pinecone, FAISS
1mo
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Audio-Visual Systems Programmer
San Diego, California, United States
$95k-$125k/yr OnsiteFull Time
FORTÉ: Designs and installs audiovisual and collaboration technology for workplaces.
Troubleshoot and program complex AV systems; install AV hardware; knowledge of DSP, switchers, Dante/AES-67; Crestron/Extron/Q-SYS programming; strong communication; relevant certifications preferred.
Crestron, Extron, Q-SYS, Dante, AVB, AES-67, AMX, HTML5, C#, Python, LUA, SIMPL, SIMPL+, CTS
3w
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Senior Scientist
Riverside or Aguadilla
OnsiteFull Time
10+ YOESenior Scientist with 10+ years experience in C4I, AMOSS, ISR; DoD/DHS environment exposure; travel; Secret clearance.
Python, R, Data visualization tools, Microsoft Office
4w
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Director, Computational Biology
Carlsbad or Boston or Remote
$200k-$250k/yr HybridFull Time
8+ YOE1+ MgmtPhD in computational biology or related field; 8+ years experience; leadership experience; multi-omics expertise; strong programming.
Python, R, Bash, Docker, Nextflow, AWS
4d
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Senior Hydrogeologist / Principal Hydrogeologist
Fountain Valley, California, United States
$65-$89/hr OnsiteFull Time
6+ YOE3+ MgmtExperience in groundwater modeling and project management; supervision; Master’s preferred; California professional geologist license.
GW Vistas, Python, ArcGIS, MODFLOW
1mo
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10512 - Program Manager, Applications Development & Management
Irvine, California, United States
$119k-$183k/yr OnsiteFull Time
10+ YOE2+ MgmtBachelor's degree or equivalent; 10+ years IT experience across web development, solution architecture, AWS, AI, project management, QA, and Adobe Experience Cloud; strong communication and leadership.
AWS, Adobe Experience Cloud, AEM, Analytics, Target, JavaScript, Python, CI/CD
3w
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Sr. Quantitative Modeler
Irvine, California, United States
HybridFull Time
8+ YOELead design and development of predictive models; provide analytic support; collaborate with auditors and stakeholders.
SAS, Python, R
HiringCafe market data
Python Developer Jobs market signals in Temecula, CA, US
These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.
Open jobs
580+
Hiring companies
190+
Fresh sample
63% new in 30d
Salary visibility
88% show pay
Companies appearing in this market
Canon U.S.A.PfizerRockstar GamesArloCACICotalityEdwards LifesciencesIngram Micro
Work location mix in visible results
Hybrid: 26Onsite: 22Remote: 4