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Python Software Engineer Jobs in Lowell, MA, US
950+ python software engineer jobs from 310+ companies hiring in Lowell, MA, US.
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Senior Full Stack Web Engineer (Modern Web + AI-Enabled SaaS)
Medford, Massachusetts, United States
$120k-$135k/yr HybridFull Time
3+ YOESenior full stack engineer with strong React/TypeScript, AWS, CI/CD, and AI-enabled SaaS experience.
React, TypeScript, Nx, Turborepo, AWS, GitHub Actions, GitLab CI, TanStack, Python, FastAPI, Pydantic, LangGraph
2w
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Senior Backend Engineer, Enterprise AI
San Mateo or Boston or New York City or Salt Lake City or Lahore
HybridFull Time
Proven backend development experience; scale enterprise AI product; cloud platforms; mentoring; agile culture; strong communication; AI in workflows.
Go, Python, Java, Google Cloud Platform, Amazon Web Services, Microsoft Azure
2mo
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Full Stack Innovation Engineer
Westborough, Massachusetts, United States
OnsiteFull Time
5+ YOE5+ years in full-stack development or solutions architecture; experience with AI tools, rapid prototyping, and cross-functional collaboration.
React, Vue.js, Python, Node.js, TensorFlow, PyTorch, Cursor, GitHub Copilot, Figma, AWS, Azure, GCP, MLOps
1mo
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Payer Dev, Git & ML-Ops Engineer, Senior Associate
Boston or Indianapolis or Raleigh or Charlotte or Jacksonville or Chicago or Cincinnati or Cleveland or Columbia or Kansas City or Columbus or Dallas or Las Vegas or Los Angeles or Baltimore or Birmingham or St. Louis or Salt Lake City or San Diego or San Francisco or Silicon Valley or Seattle or Stamford or Tampa or Toledo or Austin or Washington or New York or Florham Park or Philadelphia or Phoenix or Pittsburgh or Houston
$77k-$202k/yr OnsiteFull Time
4+ YOEBachelor's degree; 4+ years software or data engineering; experience with dbt on Databricks; healthcare analytics experience; CI/CD pipelines for Databricks; Azure Databricks workspace provisioning; Python CLI tools.
Databricks, dbt, Azure Databricks, Python, YAML, argparse, CI/CD, AI agent systems
1w
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Tulip Application Developer Aved
Billerica, Massachusetts, United States
$80k-$100k/yr OnsiteFull Time
Experience building Tulip or similar low-code apps; manufacturing process knowledge; IoT/data integration experience; strong collaboration skills.
Tulip, API integration, SQL, OPC-UA, JavaScript, Python
3w
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Platform Technologies Language & Frontend Design Engineer
Santa Clara or Berkeley or Boston
$140k-$171k/yr OnsiteFull Time
BS/MS/PhD in CS/EE/CE or equivalent; experience with OO and functional languages; Scala experience preferred; strong communication; hardware design exposure a plus.
Scala, Python, C++, Chisel, LLVM CIRCT, MLIR, Java, Kotlin
1mo
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Lead Cloud DevOps Platform Engineer
Newark or Marlborough or Santa Clara
$128k-$201k/yr HybridFull Time
6+ YOELead DevOps role with 6+ years in cloud platforms (AWS/Azure/GCP), IAM, VPC, and managed services; strong Kubernetes, IaC, DevEx, security and regulatory compliance experience.
Kubernetes, Terraform, Pulumi, GitHub Actions, Azure DevOps, Jenkins, Ansible, HashiCorp Vault, AWS Secrets Manager, C#, C++, Python, Java
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Temporary Online Course Developer –RITM 115 Programming for Systems Automation & Data Workflows
Waltham, Massachusetts, United States
$3k/bi-wk RemotePart Time
3+ YOEMaster’s degree in CS/Software/IS/Data Eng or related; 3+ years automation programming; strong scripting in Python/PowerShell/Bash/JavaScript; LMS experience; remote course development for graduate/adult learners.
Python, PowerShell, Bash, JavaScript, Airflow, Prefect, Azure Data Factory, AWS Step Functions, Moodle, H5P
1mo
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Cloud Engineering Manager
Marlborough, Massachusetts, United States
$160k-$190k/yr OnsiteFull Time
7+ YOE2+ MgmtLead architecture and delivery of cloud platform; 7+ years software development, 2+ years managing engineers, AWS, Python, MQTT, IoT, and cloud pipelines.
AWS, Python, MQTT, REST APIs, JIRA, Git
1mo
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Assoc Director,Marketing Technology, Data and Software Engineering (Cambridge, MA, US, 02142)
Cambridge, Massachusetts, United States
$172k-$233k/yr HybridFull Time
10+ YOE5+ Mgmt10+ years data/software/platform engineering; 5+ years leadership; 3+ years marketing data pipelines; Snowflake/dbt/Fivetran; AWS Bedrock; CDP experience; pharma/biotech familiarity preferred.
Snowflake, dbt, Fivetran, Airflow, AWS Bedrock, SageMaker, Salesforce Data Cloud, Adobe Experience Platform, Veeva, Python, SQL, REST, GraphQL, CI/CD, Infrastructure-as-code, S3, Lambda, Snowpipe
3w
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Sr. Manager, Investments Technology
Boston or Houston or Atlanta
$185k-$195k/yr HybridFull Time
10+ YOE3+ Mgmt10+ years in software engineering with 3–5+ years leading teams; strong system design; AI-enabled development; Python and AWS; FinOps; CFA/CPA/CIPM/CAIA/FRM preferred.
Python, AWS, Docker
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Staff Computational Biologist
Lexington or United States
$166k-$195k/yr HybridFull Time
6+ YOE6+ years in computational biology/data-driven discovery; 1+ year in software/data engineering; Python and R; omics/translational analysis; ETL pipelines; product-owner experience.
Python, R, Omics data analysis, ETL pipelines
2w
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Financial Advisory Senior AI Solution Architect (Nationwide, Remote)
New York or Denver or Georgia or Pennsylvania or Boston or Chicago or Houston or Dallas or Seattle or Detroit or New Jersey or California
$165k-$215k/yr RemoteFull Time
8+ YOE8–12 years in software engineering/AI development; Python expert; experience with LLM APIs, document processing; cloud deployments (AWS/Azure); CI/CD; strong communication.
Python, LLM APIs, API development, PowerPoint, Excel, AWS, Azure, Git, Seismic, Salesforce, OpenSearch, SQL, python-pptx, openpyxl
2w
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Sr. Digital Manufacturing Technical Specialist
Norwood, Massachusetts, United States
$100k-$161k/yr HybridFull Time
2+ YOEBS/MS in CS/Engineering/Data Science; 2-4 yrs AI/ML in production; strong software engineering; GenAI/LLM; cloud platforms; US work authorization.
Cloud platforms, Generative AI, LLM, APIs, RAG, Python, Software engineering
1w
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Member of Technical Staff - Product Engineer (Internal Data & Agent Platform)
San Francisco or Cambridge or Germany
HybridFull Time
5+ YOE5+ years software engineering; experience building data pipelines, integrations, or internal platforms; hands-on LLM production experience; strong Python; TypeScript for frontend/tooling; experience integrating SaaS APIs.
Python, TypeScript, Slack API, GitHub API, Google Workspace API, HRIS API
2w
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Firmware Engineering Co-Op - Fall 2026
Boston, Massachusetts, United States
$42/hr HybridAll Commitments Available
Enrolled in computer engineering, computer science, or related engineering; experience with C and Python; firmware development; embedded systems; hardware debugging; knowledge of I2C, SPI, UART; collaboration across teams.
C, Python, JTAG, Oscilloscope, Multimeter, Bus Analyzer, I2C, SPI, UART
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Manager, Data Science (GenAI Solutions & ML Engineering) (Boston, MA, US, 02110)
Boston, Massachusetts, United States
$131k-$164k/yr OnsiteFull Time
5+ YOE3+ MgmtBachelor’s degree; 5+ years in Machine Learning Engineering, Applied AI, or MLOps; 3+ years leading technical teams; strong end-to-end AI systems; Python and PyTorch; enterprise integration.
Python, PyTorch, ML frameworks
2mo
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Analog Design Automation Intern
Toronto or Boston or Austin or Santa Clara
$35-$70/hr HybridInternship
Co-op or PEY student in Electrical Engineering with analog IC design exposure; Python proficiency; interest in ML concepts; open source tools; strong analytical and communication skills.
Python
3w
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Digital Tools & AI Builder CMC TechOps Co-Op
Cambridge, Massachusetts, United States
$25-$35/hr OnsiteInternship
Pursuing CS/Data Science/Engineering; hands-on app-building experience; familiarity with React/JS, Python, HTML/CSS, SQL; interest in AI tools; ability to work on-site in Cambridge, MA.
React, JavaScript, Python, HTML/CSS, SQL, AI tooling
4w
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AI Technical Architect
New York or Chicago or Boston
$120k-$140k/yr HybridFull Time
9+ YOEBachelor's or master's in CS/DS/Engineering; 9-10 yrs AI/ML experience; strong Python, SQL/NoSQL; ML/AI development & deployment; cloud (AWS/Azure/GCP); GenAI exposure; API development; math/statistics knowledge.
Python, SQL, NoSQL, TensorFlow, PyTorch, Scikit-learn, OpenCV, Keras, Flask, Django, AWS, Azure, GCP, OpenAI, Google Gemini, Runway ML, Vector DB/Embeddings, LLM
1mo
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Solutions Architect
Boston, Massachusetts, United States
$175k-$210k/yr HybridFull Time
7+ YOE7+ years in Solutions Architecture/Applied Engineering for enterprise SaaS or ML/LLM products; strong system design; LLM/AI familiarity; practical coding (JS/Node/TS or Python); excellent writing; CX/Support stack experience a plus.
JavaScript, Node.js, TypeScript, Python, REST, GraphQL, APIs, webhooks, ETL, iPaaS
1mo
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Manager, Engineering
Raleigh or Chicago or Franklin or Boston
$148k-$175k/yr HybridFull Time
5+ YOE5+ Mgmt5+ years of technical leadership; 5+ years in operations optimization; tests, reports, and documentation experience; strong Python, Django, PySpark, ETL, SQL skills.
Python, Django, PySpark, ETL, SQL
1mo
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Lead AI Solutions Architect - Full Stack
Princeton or Glen Allen or Coppell or Waltham or Philadelphia or Riverwoods or New York City or Chicago or Houston
$129k-$226k/yr HybridFull Time
10+ YOELeadership-focused AI solutions architect with 10+ years in full-stack engineering, GenAI/Agentic AI, data science, AI/ML, and applied AI engineering; proven leadership and mentoring experience.
Python, FastAPI, Angular, React, LangChain, LlamaIndex, SQL, NoSQL, Azure, AWS
2w
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DevOps Co-Op
Burlington, Massachusetts, United States
OnsiteInternship
Pursuing a Masters in CS/Software Engineering; Linux networking; cloud platforms (AWS/Azure/GCP); scripting (Python/Bash); Git and CI/CD; Docker/Kubernetes.
AWS, Azure, GCP, Jenkins, GitHub Actions, GitLab CI, Docker, Kubernetes, Python, Bash, Terraform, CI/CD
2mo
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Data Science Intern - Summer 2026 - Bedford, MA
Bedford, Massachusetts, United States
$40-$50/hr HybridInternship
5+ YOEMaster’s in CS/Engineering/OR or related field; 5+ years data analysis and software development; Python, C/C++/C#; ML/AI experience; strong math/statistics; cloud/LLM a plus; US work authorized.
Python, C++, C#, C, Machine Learning, LLM, MLops, Cloud
1mo
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Data Analyst, Sr.
Charlestown, Massachusetts, United States
$80k-$116k/yr OnsiteFull Time
Mass General Brigham: Provides integrated medical care, research, and clinical training services.
5+ YOEBachelor's degree in engineering/applied math/computer science or related field; 5-7 years data analysis experience; strong Python skills; experience with neuroimaging/microscopy tools; ability to develop and assess software pipelines; excellent communication and organizational skills.
FreeSurfer, FSL, ImageJ, TensorFlow, PyTorch, Python, MATLAB, JavaScript, TypeScript
2mo
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Director, Engineering
Waltham, Massachusetts, United States
$161k-$241k/yr OnsiteFull Time
3+ YOELeads DevSecOps, platform engineering, and security for scalable software systems; 3+ years in technical leadership; strong cloud, CI/CD, and security expertise; hands-on architectural and coding skills.
Java, Python, Go, Node.js, Git, Jira, AWS, Azure, GCP, Terraform, CloudFormation, Docker, Kubernetes
2mo
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Research and Development Solution Architect - Digital Lab Operations
Morristown or Cambridge
$134k-$193k/yr OnsiteFull Time
5+ YOE5-8+ years of solution architecture experience; CS/IS/Software Engineering background; strong IT governance, GxP, HIPAA, GDPR knowledge; English communication; vendor management; cross-functional collaboration.
Snowflake, GitHub, IICS, Python, OpenShift, ReactJS, SQL, AWS, Azure
2mo
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Industrial AI Applications Lead
Philadelphia or Boston or New York
$225k-$375k/yr HybridFull Time
10+ YOE10+ years in industrial systems or AI-enabled software with 3+ years in a customer-facing technical lead role; BS in CS/Engineering/Industrial Systems; strong industrial domain knowledge; hands-on AI deployment; cross-functional leadership.
Python, Machine Learning, TensorFlow, PyTorch, Cloud, Industrial Control Systems
HiringCafe market data
Python Software Engineer Jobs market signals in Lowell, MA, US
These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.
Open jobs
950+
Hiring companies
310+
Fresh sample
39% new in 30d
Salary visibility
85% show pay
Companies appearing in this market
Cumberland FarmsOverjetPwCWolters KluwerAlnylamAspenTechAVEVABrandeis University
Work location mix in visible results
Hybrid: 17Onsite: 13Remote: 3