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Senior Level Python Developer Jobs in United States
18,000+ senior level python developer jobs from 4,300+ companies hiring in United States.
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Senior‑Level Python Developer (Python, C++)
Annapolis Junction, Maryland, United States
$155k-$175k/yr OnsiteFull Time
8+ YOEBachelor’s degree in computer science; 8+ years relevant experience; Python, C++, Spark; Jupyter Notebooks; JIRA, Confluence, Git/GitLab; knowledge of customer tools; active TS/SCI with Polygraph.
Python, C++, Spark, Jupyter Notebooks, JIRA, Confluence, Git/GitLab
2w
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Senior Python Developer
Egg Harbor Township, New Jersey, United States
$100k-$155k/yr OnsiteFull Time
9+ YOESenior Python developer with 9+ years, strong in messaging systems, REST/microservices, async, QA, Agile.
Python, Messaging brokers, REST APIs, Docker, Kubernetes, Cloud platforms, Oracle/SQL/NoSQL, Java, Go, CI/CD, Agile tooling (JIRA)
2w
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Senior Python Developer
United States
$68k-$132k/yr RemoteFull Time
6+ YOE6+ years Python development; strong PySpark, SQL, Airflow; cloud experience (GCP or Azure); design of large-scale, high-volume analytics/data engineering solutions; collaborative cross-functional work.
Python, PySpark, SQL, Airflow, Google Cloud Platform, Azure, BigQuery, Power BI, Looker Studio, Scala
2mo
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Python Senior Developer
Tampa, Florida, United States
$97k-$145k/yr HybridFull Time
3+ YOE3-5 years hands-on application development; 3+ years Python; REST APIs, FASTAPI; Airflow; Kafka; S3; SQL Server/Oracle; Docker; EKS; Grafana/OpenTelemetry; strong problem solving and communication.
Python, REST APIs, FASTAPI, Apache Airflow, Apache Kafka, Amazon S3, SQL Server, Oracle, Docker, Amazon EKS, OpenTelemetry, Grafana, Trino, Starburst, Pinot, Spark
1mo
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Senior Python Developer
Fairfax, Virginia, United States
OnsiteFull Time
7+ YOEStrong Python, Elastic Stack, 7-9+ years building enterprise apps, systems integration, CI/CD, data modeling, and distributed storage tech.
Python, Pandas, BeautifulSoup, NumPy, Boto3, Elasticsearch, Kibana, Docker, Kubernetes, AWS, Git, CI/CD, RabbitMQ, Kafka, Logstash, Beats, Splunk, Terraform
1w
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Senior Python Developer - Contingent
McLean, Virginia, United States
RemoteFull Time
8+ YOE8+ years Python development, 8+ years OOP, Bachelor’s or 2 extra years, API/microservices, AWS, Docker/Kubernetes, CI/CD, Agile.
Python, FastAPI, Docker, Kubernetes, Terraform, AWS, PostgreSQL, MySQL, Solr, Elasticsearch, JQuery, JavaScript, CI/CD
1mo
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Senior Python Developer with AI ML Experience
Charlotte, North Carolina, United States
$110k-$120k/yr OnsiteFull Time
Senior Python developer with AI/ML experience; strong Python, REST, Unix, SQL; CI/CD, OpenShift; Mongo, Redis, S3; communication.
Python, REST API, Unix, SQL, OpenShift, Mongo, Redis, S3, CI/CD, Bitbucket, Ansible
2w
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Senior Python Engineer, AI
United States
$119k-$206k/yr RemoteFull Time
5+ YOE5+ years Python backend development; experience building asynchronous microservices, APIs, and AI/LLM integrations; strong communication and cross-functional collaboration.
Python, FastAPI, asyncio, REST API, CI/CD, Docker, Kubernetes, Git
1mo
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Senior Python Engineer
San Francisco, California, United States
$126k-$248k/yr HybridFull Time
Strong Python software development experience; practical AI/ML framework knowledge in Python; open source contribution; strong communication; mentoring; self-motivated with time management.
Python, AI/ML frameworks, LangChain, PyMongo, Django, Web development frameworks, Open source tooling
3w
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Senior Python Engineer
United States
$200k-$225k/yr RemoteFull Time
5+ YOE5+ years backend software engineering; strong Python; API design; production ML/AI experience; cloud platforms; Docker/Kubernetes.
Python, AWS, GCP, Azure, Docker, Kubernetes, SQL, NoSQL, LLMs, ML
2w
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Senior Python Developer
United States
$68k-$132k/yr RemoteFull Time
6+ YOE6+ years Python development; strong PySpark, SQL, Airflow; cloud experience (GCP or Azure); large-scale, high‑volume applications; collaboration across cross-functional teams.
Python, PySpark, SQL, Airflow, Google Cloud Platform, Azure, BigQuery, Power BI, Looker Studio, Scala
1mo
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Senior Python Engineer, Document App
United States
RemoteFull Time
5+ YOE5+ years Python development; relational DB experience; message queues; event-based systems; AsyncIO; full software development lifecycle; experience with monoliths and microservices; English communication.
Django, Python, PostgreSQL, Redis, Memcached, AWS, Docker, Kubernetes, Kafka, NATS, AsyncIO, RabbitMQ, Grafana, Loki, Tempo, Mimir
2w
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Senior Backend Python Engineer
Redmond, Washington, United States
$135k-$180k/yr OnsiteFull Time
5+ YOESenior backend Python engineer with 5+ years in DevOps/Data Engineering/AI infra; strong Python, backend APIs, data pipelines, and integrations; familiar with Prefect, Kubernetes, REST/JSON, HTML scraping, and CI/CD.
Python, FastAPI, Flask, Django REST, Prefect, Kubernetes, Splunk, REST/JSON, HTML scraping, CI/CD, SQL, NoSQL
2mo
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Senior Level Developer
Suitland-Silver Hill, Maryland, United States
HybridFull Time
8+ YOE8+ years software development; expert Python; AWS cloud native; API/microservices; migration from on-prem to AWS; CI/CD; Agile; US citizenship.
Python, AWS, Lambda, ECS, EKS, Fargate, Aurora/Postgres, EventBridge, S3, IAM/KMS, SNS/SQS, Glue, Batch, APIs, Serverless, CI/CD, GitLab, Terraform/CloudFormation
2w
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Python Developer
Fort Meade, Maryland, United States
$130k-$265k/yr OnsiteFull Time
6+ YOESr. Python developer with TS/SCI clearance, advanced degree options, and 6+ years Python experience; strong math/data science background.
Python
2mo
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Python Engineer, Senior Associate
Boston, Massachusetts, United States
$133k-$185k/yr OnsiteFull Time
6+ YOE6+ years software development, Python, AWS, Django/React; Bachelor’s in Computer/Electrical/IT Engineering; strong communication; CI/CD; financial data experience preferred.
Python, Pandas, Polars, GitHub, Bitbucket, Jenkins, Jira, PostgreSQL, AWS (EC2, EKS, RDS, ElastiCache, S3, Lambda, Secrets Manager, CloudWatch), Django, Redis, React, Linux
1w
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Spatial Front, Inc - Senior Python Developer
United States
$100k-$150k/yr RemoteFull Time
10+ YOE10+ years software development; 5+ years Python; 3+ years SQL/Relational databases; 3+ years Linux/Unix; U.S. work authorization with ability to obtain Public Trust clearance.
Python, SQL, Oracle, PostgreSQL, Linux, GeoPandas, ArcGIS
2w
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Python Developer III
Jersey City, New Jersey, United States
$103k-$180k/yr HybridFull Time
7+ YOESenior Python developer with 7+ years, distributed systems, front office exposure, CI/CD, mentoring.
Python, Quartz, CI/CD
3w
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Senior Python Core Engineer
United States
$187k-$259k/yr RemoteFull Time
5+ YOE5+ years software engineering; deep Python production experience; strong Python build tooling; containerized environments; maintain shared libraries; on-call rotation; collaboration with CI/CD and data/ML teams.
Python, Docker, CI/CD, versioning, dependency management, APIs, library development
2mo
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Python Developer
Woodlawn, Maryland, United States
$144k-$197k/yr OnsiteFull Time
1+ YOEDesign and develop large-scale Python applications with ML/LLM, data processing with NumPy/Pandas, performance analysis, collaboration, TDD, Git, SQL, security, agile practices, and cloud deployment.
Python, NumPy, Pandas, Git, Bitbucket, Visual Studio Code, PostgreSQL, MongoDB, SQL, Splunk, Dynatrace, AWS, Azure, Jenkins
2w
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Python Developer IV
Webster or Chicago or St Petersburg or Phoenix or Tempe
$111k-$175k/yr HybridFull Time
5+ YOE5+ years backend software development; Python/Django; AWS; REST APIs; PostgreSQL/MySQL; Docker; CI/CD.
Python, Django, REST, Celery, Redis, AWS, EC2, S3, RDS, Lambda, CloudWatch, PostgreSQL, MySQL, Docker, Kubernetes, Jenkins, GitHub Actions
5d
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Senior Python Programmer
Princeton, New Jersey, United States
$40k-$80k/yr HybridFull Time
7+ YOESenior Python programmer with 7+ years in systems engineering or web development; expert in Python; HPC/GPU experience; ability to obtain Public Trust.
Python, Git, GPU programming, HPC
2w
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Principal Python Engineer
United States
RemoteFull Time
Senior Python engineer; design/own backend services, APIs; strong unit testing; DevOps practices; AI-enabled development.
Python, FastAPI, Temporal, Postgres, Docker, Kubernetes, Pulumi, Vue.js, SQL, Unit testing, CI/CD
3d
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Python Developer
Fort Meade, Maryland, United States
OnsiteFull Time
7+ YOEBachelor's degree in Computer Science or related; 7+ years SWE experience; TS/SCI clearance with polygraph; strong Python; NiFi or Elasticsearch a plus.
Python, NiFi, Elasticsearch
2w
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Senior Python/AI Engineer
North America
RemoteContract
5+ YOE5+ years software engineering; strong Python; experience with LLMs, AI integration, prompt engineering, and multi-agent systems; document/image processing; good English.
Python, LLMs, Bedrock, AI frameworks, Prompt engineering, Agent-based systems
2mo
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Remote - Middle to Senior Python Developer - (Payment Team)
United States
RemoteContract, Full Time
Torrero: Provides white-label casino and sportsbook platforms for iGaming.
5+ YOE5+ years commercial Python/Django development; strong Python 3.x, Django; experience with highly loaded systems; English and Russian language proficiency; knowledge of design patterns, data structures, and algorithms.
Python, Django, PostgreSQL, MongoDB, RabbitMQ, Redis
2mo
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Senior Python Software Engineer
Linthicum Heights, Maryland, United States
$170k-$260k/yr OnsiteFull Time
6+ YOEActive TS/SCI with Polygraph clearance; U.S. citizenship; 6+ years software engineering with MS in CS (or 8+ years with BS), or 10+ years with AA, or 12+ years with high school diploma; strong communication and independent work skills.
Python, Docker, Django, Flask, MongoDB, MariaDB, REST, JSON, XML, Jira, Confluence, Git, AWS
1mo
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Python Developer (48527)
United States
RemoteFull Time
7+ YOE7-9 years experience in ML/AI, Python/Java/Scala, ML frameworks, cloud and containerization; deployment in production.
Python, Java, Scala, TensorFlow, PyTorch, Keras, Docker, Kubernetes, AWS
6d
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Sr. Python Engineer, Agentic AI
Washington, District of Columbia, United States
$168k-$252k/yr HybridFull Time
7+ YOESenior backend engineer with Python experience, AI/agentic workflows, scalable systems, observability, and mentorship.
Python, FastAPI, Asyncio, LLMs, APIs, Microservices, Distributed Systems
2w
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Python Software Developer
Ashburn, Virginia, United States
HybridFull Time
4+ YOE4+ years software development; Python proficiency; strong SQL; GraphQL APIs; REST; Git/Linux/Docker; web security; cloud; microservices; bachelor's degree or equivalent; authorized to work in the United States
Python, GraphQL, REST, SQL, Git, Linux, Docker, OpenAPI
6d
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Senior Java / Python Developer with Productions Support experience
Lake Mary or Pittsburgh
$65k-$150k/yr OnsiteFull Time
5+ YOEHands-on software development in large-scale distributed systems; 5+ years in Java and Python; Linux, Oracle SQL/PLSQL; cloud platforms (OCI/AWS/Azure/GCP); DevOps (CI/CD); AI tools; strong problem solving and communication.
Java, Python, Linux, Oracle, SQL, PL/SQL, OCI, AWS, Azure, GCP, CI/CD, AI tools
1w
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Sr Staff / Senior Python Software Engineer
Boulder, Colorado, United States
$126k-$175k/yr OnsiteFull Time
6+ YOEBachelor’s degree in CS/Engineering/Math/Physical Sciences; 6+ years of professional Python software engineering; microservices and distributed systems; real-time data processing pipelines; automated testing; Linux; Git; DoD clearance; strong communication.
Python, Linux, Docker, Git, pytest, CI/CD, Microservices, Distributed Systems, REST APIs, protobuf, ZeroMQ, Kafka, gRPC
2mo
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Python Software Engineer
Dallas, Texas, United States
$70-$90/hr OnsiteFull Time
7+ YOE7–10+ years software development experience; proficient in Python; experience with Azure Functions, APIs, event-driven architectures; cloud, AI/ML exposure.
Python, C#, TypeScript, Azure Functions, APIs, API Management, Azure Event Grid, Durable Functions, LangChain, AutoGen, Semantic Kernel
3mo
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Senior AI Python Software Engineer (Perm, USA, Remote + Travel)
United States
RemoteFull Time
Nearform: Builds cloud-native software and AI solutions for enterprise clients.
8+ YOESenior Python developer with 8+ years experience; strong AI/LLM knowledge; agile delivery; Git, CI/CD, databases, cloud; English proficiency; strong collaboration.
Python, Git, CI/CD, Kubernetes, React, Golang, SQL, Cloud
6d
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Senior Python Engineer, Truework
San Francisco, California, United States
$185k-$218k/yr HybridFull Time
5+ YOE5+ years software development; Python and JavaScript; REST APIs; strong communication; ownership; external collaboration.
Python, JavaScript, REST APIs
1mo
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Senior Software Engineer (Python)
Columbia, Maryland, United States
$170k-$240k/yr OnsiteFull Time
12+ YOESenior software engineer with 12+ years exp, Python expert, production apps, AI concepts, Kafka, Elasticsearch; TS/SCI with polygraph.
Python, Kafka, Elasticsearch, PydanticAI, LangGraph
3w
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Senior Software Engineer - Python
New York, New York, United States
OnsiteFull Time
Strong Python development, data engineering, ETL, and SQL expertise; experience with cloud data platforms and data reconciliation.
Python, Informatica, Snowflake, Redshift, BigQuery, SQL, Shell, Bash, PowerShell
1mo
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Senior Full Stack Python/JavaScript Developer
San Antonio or United States
$92k-$153k/yr HybridFull Time
6+ YOEUS citizen or green card; Bachelor’s degree or 4 years experience; 6+ years full-stack development; 3+ years AWS cloud; Python and JavaScript proficiency; Django/Flask and Vue.js/React alternatives; Agile; no visa sponsorship; able to obtain public trust.
Python, JavaScript, Django, Vue.js, Flask, FastAPI, Angular, React, Svelte, Docker, AWS, PostgreSQL, SQLAlchemy
1mo
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Sr. Python Backend Developer
United States
$120k-$160k/yr RemoteFull Time
5+ YOE5+ years Python backend development; SQLModel/SQLAlchemy; MS SQL Server; RESTful APIs; Azure; Jira/Bitbucket/Git; strong problem solving and communication.
Python, FastAPI, SQLModel, SQLAlchemy, MS SQL Server, Azure, Jira, Bitbucket, Git, pytest
5d
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Senior Software Engineer -Python
Salt Lake City, Utah, United States
$140k-$217k/yr OnsiteFull Time
6+ YOESix years software development experience; BS in CS or related; Python, REST, JavaScript/Angular/React; experience with databases and integrating third-party products.
Python, REST, JavaScript, Angular, React, AWS, Kafka, Django, JIRA, Git, IntelliJ, VS Code
HiringCafe market data
Senior Level Python Developer Jobs market signals in United States
These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.
Open jobs
18,000+
Hiring companies
4,300+
Fresh sample
58% new in 30d
Salary visibility
73% show pay
Companies appearing in this market
CognizantAccenture Federal ServicesAlvarez & MarsalASRC FederalBank of AmericaCheckrChimeCiti
Work location mix in visible results
Onsite: 70Hybrid: 30Remote: 30