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Senior Python Developer Jobs in Centennial, CO, US
660+ senior python developer jobs from 210+ companies hiring in Centennial, CO, US.
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Sr Staff / Senior Python Software Engineer
Boulder, Colorado, United States
$126k-$175k/yr OnsiteFull Time
6+ YOEBachelor’s degree in CS/Engineering/Math/Physical Sciences; 6+ years of professional Python software engineering; microservices and distributed systems; real-time data processing pipelines; automated testing; Linux; Git; DoD clearance; strong communication.
Python, Linux, Docker, Git, pytest, CI/CD, Microservices, Distributed Systems, REST APIs, protobuf, ZeroMQ, Kafka, gRPC
1d
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Senior Software Engineer (Java/Python)
Pittsburgh or Cleveland or Birmingham or Dallas or Denver or Strongsville
$55k-$152k/yr OnsiteFull Time
3+ YOESenior software engineer with Java and Python experience; in-office role; candidates must be eligible to work in the United States; visa sponsorship not provided.
Java, Python
4w
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Senior Software Engineer, Network Tools with Python
Denver, Colorado, United States
$113k-$174k/yr OnsiteFull Time
7+ YOE7+ years in software development; strong Python, JavaScript, SQL, GraphQL; experience with databases; network protocols; automation tools; Linux; Docker; communication and collaboration skills.
Python, Javascript, SQL, GraphQL, Postgres, MySQL, MongoDB, Oracle, Docker, Ansible, Terraform, ServiceNow, Jira, Confluence, Google Suite
3w
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Senior Software Developer
Louisville, Colorado, United States
$118k-$144k/yr OnsiteFull Time
5+ YOE5+ years of professional software development; strong SQL; Python; Git; REST APIs; pytest or similar testing; CI/CD experience; ability to own features end-to-end.
Python, SQL, Git, REST APIs, pytest, JavaScript, TypeScript, Node.js, CI/CD, GitLab CI
1mo
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Senior CNO Developer
Aurora, Colorado, United States
OnsiteFull Time
8+ YOESenior CNO Developer with 8+ years (PhD) to 16+ years (HS) of technical experience; expert in Python/C/C++, CNO development, and network security.
Python, C/C++, TCP/IP, socket programming
1mo
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Senior AI Engineer
Denver, Colorado, United States
$150k-$184k/yr HybridFull Time
6+ YOE6+ years software development; 2+ years in production GenAI; strong Python; LLM experience; observability and security mindset.
Python, LangGraph, LangChain, Semantic Kernel, PyTorch, TensorFlow, scikit-learn
3d
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Senior Software Engineer/Full Stack Developer
Denver or Naperville
HybridFull Time
7+ YOESenior software engineer with strong full-stack skills; experience with Java, Node.js, SQL, Python; design and develop web/cloud apps; 7+ years experience; hybrid in Naperville, IL or Denver, CO.
Java, Node.js, SQL, Python, APIs, Web Sockets, ClaudeCode, CoPilot, Unix, Shell scripting, MS SQL Server, PostgreSQL, Azure SQL, Oracle, JSON, HTTP
6d
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Senior Software Engineer
Boulder, Colorado, United States
$145k-$175k/yr OnsiteFull Time
Foresight Diagnostics: Develops ultra-sensitive blood tests for cancer recurrence monitoring.
8+ YOE8+ years full-stack development; Python backend; React frontend; PostgreSQL; Docker/Kubernetes; AWS or GCP; strong problem-solving and communication.
Python, React, PostgreSQL, Docker, Kubernetes, AWS, GCP
2w
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Senior Software Engineer
Warrenton or State College or Fort Eisenhower or Centennial
OnsiteFull Time
Strong Java and JavaScript/TypeScript skills; full-stack development; experience with Java, Python, JavaScript, Angular, React, ElasticSearch; BS in CS/CE/EE.
Java, Python, JavaScript, TypeScript, Angular, React, ElasticSearch, Docker, Kubernetes, Redis, REST, NoSQL, SQL, Xmidas
2w
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Senior Software Engineer
Longmont, Colorado, United States
$115k-$145k/yr OnsiteFull Time
5+ YOE5+ years of professional software development; automation testing frameworks; Java, Python, JavaScript/TypeScript, or C#; backend services/APIs; CI/CD; AI-assisted tools.
Playwright, Cypress, Selenium, pytest, REST-assured, Criterion, Java, Python, JavaScript/TypeScript, C#, Copilot, Claude
2w
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Software Engineer Senior (Networking)
King of Prussia or Littleton
OnsiteFull Time
5+ YOESenior software engineer with networking experience; Java/Python skills; strong problem-solving and collaboration.
Java, Python, REST APIs, Docker, Kubernetes, Elastic Stack, ActiveMQ, CI/CD, Web applications
4d
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Senior Software Engineer, Truework
San Francisco or Denver or San Francisco or Nashville or Santiago
$185k-$218k/yr HybridFull Time
5+ YOE5+ years software development; Python and JavaScript; RESTful APIs; Bachelor’s degree or equivalent; strong communication; ownership and collaboration; eager to learn.
Python, JavaScript, REST API
3w
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Senior AI DevOps Engineer
Littleton, Colorado, United States
$96k-$138k/yr OnsiteFull Time
5+ YOESenior AI-focused engineer with 5+ years backend/full-stack exp, Python/Java, AI/ML, and cloud experience.
Python, Java, Kubernetes, AWS, Serverless, EC2, LangChain, LlamaIndex, Haystack, Milvus, GraphQL, REST, Bash, Ansible
2w
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Full Stack Developer (.Net/Python)
Denver or New York
$130k-$160k/yr HybridFull Time
7+ YOE7+ years of industry experience; BA/BS in Computer Science or related field; strong .NET and Python skills; financial services domain knowledge.
C#, Python, Angular, React, Vue, HTML, CSS, JavaScript, XML, JSON, JQuery, REST, Docker, Kubernetes, SQL, NoSQL, CI/CD
2w
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Senior Full-Stack Engineer
Denver or New York
$145k-$206k/yr HybridFull Time
7+ YOESenior full-stack engineer with backend focus; 7+ years’ experience; proficient in Python, Node.js, or Go; Docker and Kubernetes; API design; fintech security/compliance; cloud platforms.
Python, Node.js, Go, Docker, Kubernetes, Redis, CI/CD, AWS, GCP, Azure, APIs
3w
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Senior Software Developer
Louisville, Colorado, United States
$118k-$144k/yr OnsiteFull Time
5+ YOE5+ years in professional software development; strong Python; SQL; REST APIs; Git; CI/CD; excellent communication; Bachelor’s degree in CS/Software Engineering.
Python, SQL, Git, GitLab CI, pytest, REST APIs, JavaScript, TypeScript, Node.js
4w
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Engineer Senior - Digital Test Developer
Westminster, Colorado, United States
$97k-$165k/yr HybridFull Time
4+ YOEBS in engineering or related field with 4+ years experience; full stack web/app development; Python and Ruby; CI/CD; software lifecycle.
Python, Ruby, JavaScript, Ruby on Rails, NodeJS, Docker, Veristand, LabVIEW, Cosmos/OpenC3, CI/CD
4w
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Senior GenAI Backend Platform Developer
Rockville or Jersey City or Denver or San Francisco or New York
HybridFull Time
5+ YOESenior GenAI backend developer with 5+ years of experience in cloud-native systems, AWS, CI/CD, and secure software practices.
AWS Bedrock, AWS S3, AWS Fargate, AWS Lambda, AWS Step Functions, Jenkins, Git, Docker, Python, FastAPI
1mo
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Senior Engineer: Inference Data Plane
Denver or Seattle
$139k-$174k/yr RemoteFull Time
Distributed systems, cloud infrastructure, AI/ML experience; Go or Python; Kubernetes; experience with multi-region services.
Go, Python, gRPC, Kubernetes, Cloud networking, Observability
1d
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Software Engineer, Senior
Aurora, Colorado, United States
$87k-$198k/yr OnsiteFull Time
7+ YOESenior software engineer with 7+ years design/develop; 5+ years Java, Python, Rust, or Go; 3+ years Linux, containers, Docker/Kubernetes; cloud experience; TS/SCI with poly; BS degree; Agile experience preferred.
Java, Python, Rust, Go, Linux, Docker, Kubernetes, AWS, Azure, Google Cloud, React, Node.js
1mo
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Senior Robotics Engineer
Denver, Colorado, United States
$150k/yr OnsiteFull Time
8+ YOE8+ years in robotics/autonomous systems; strong C++ and Python; ROS/ROS2; SLAM; perception; Linux; Docker; hardware/software integration; production-grade experience; bachelor in related field; advanced degree preferred.
C++, Python, ROS, ROS2, Linux, Docker, SLAM, Perception, Navigation, AI, Machine Learning
6d
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Software Engineer, Senior
McLean or Chantilly or Beavercreek or Huntsville or Redstone Arsenal or Annapolis Junction or El Segundo or Rome or Aurora or Colorado Springs or Lexington
$87k-$198k/yr HybridFull Time
5+ YOE7+ years in software engineering; Rust, C, C++, or Python; full-stack app experience; Kubernetes; CI/CD; AI-assisted tools; secure-by-design; secret clearance; BS in CS/Engineering (5+ years) or 7+ years without degree.
Rust, C, C++, Python, Kubernetes, CI/CD, SonarQube, Clippy, cargo-deny, cargo-audit, PyO3
2mo
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Senior Platform Engineer, AI
Denver or Long Beach
$155k-$215k/yr HybridFull Time
Software engineer with AI platform experience, Python/TypeScript, LLM APIs, API integrations, and security/compliance awareness.
Python, TypeScript, LLM APIs, APIs, NVIDIA CUDA, GPU
1mo
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Senior Software Engineer – SDA
Flagstaff or Broomfield or Remote
$140k-$180k/yr HybridFull Time
5+ YOE5+ years software engineering; defense/space industry experience; Agile; Linux, Python, SQL, Docker, AWS; U.S. security clearance eligible.
AWS, Lambda, ECS, PostgreSQL, SQL, Python, Docker, Linux, ETL, Machine Learning, SDA
1w
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Senior Software Engineer
San Francisco or Denver
$150k-$200k/yr HybridFull Time
5+ YOEBachelor’s in CS or related field; 5+ years software development; strong Python, Java, Spring Boot, Kafka; microservices; AI exposure; TDD; XP; PostgreSQL; Git; Jenkins.
Python, Java, Spring Boot, Kafka, PostgreSQL, Git, Jenkins, Docker, Kubernetes, Azure, AWS, Angular, JavaScript, CSS
3mo
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Senior Program Analysis Software Engineer
San Francisco or New York City or Boston or Denver
$160k-$207k/yr HybridFull Time
Senior engineer for program analysis of code, with OCaml/Python experience; hybrid work in multiple US offices; familiarity with static analysis and performance optimization; strong collaboration with Security Research.
OCaml, Python, OpenTelemetry, Datadog
1w
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Senior Network Software Engineer
Dallas - Fort Worth Metro Area or Denver Metro Area or San Francisco Bay Area
HybridFull Time
8+ YOE8+ years software engineering; proficient in Python/Django/Golang; relation databases; REST APIs; CI/CD.
Python, Django, Golang, PostgreSQL, MySQL, REST, CI/CD, Linux, Docker, Kubernetes, Ansible, Puppet, Chef, BGP, MPLS, Netflow, SNMP, TCP/IP, TLS, HTTP, UDP, DNS, Junos, IOS, EOS
1w
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Senior Software Engineer (Full-Stack)
Denver, Colorado, United States
$160k-$210k/yr OnsiteFull Time
5+ YOE5+ years software engineering; strong React/TypeScript; Python/Django; GraphQL; PostgreSQL; AWS; monorepo; real-time UI; on-call.
React, TypeScript, WebRTC, Django, Python, GraphQL, PostgreSQL, AWS, Docker, WebSocket
4w
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Senior Salesforce Developer
Chicago or Los Angeles or New York or Oakbrook Terrace or Sacramento or San Francisco or South Bend or San Jose or Tampa or Atlanta or Boston or Columbus or Dallas or Denver or Fort Lauderdale or Grand Rapids or Houston or Austin or Charlotte or Indianapolis
$109k-$222k/yr HybridFull Time
5+ YOE5+ years Salesforce experience; proficient in Apex, Visualforce, Aura, LWC; strong frontend skills; Salesforce API; certifications preferred
Salesforce, Apex, Visualforce, Aura Components, Lightning Web Components, Salesforce API, Heroku, AWS, Python, Node.js
3w
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Senior Software Engineer - ML Systems
Denver, Colorado, United States
$176k-$206k/yr RemoteFull Time
7+ YOE7+ years in software engineering with AI production systems (Python, PyTorch) and data services; experience with CI/CD and ML platforms; strong collaboration and regulatory awareness.
Python, PyTorch, SQL, Postgres, NoSQL, Redis, Airflow, MLflow, Kubernetes, Terraform, SageMaker, Databricks, Unity Catalog, Snowflake/Snowpark
2mo
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Senior Applied AI Engineer
Denver or Chicago or East Rutherford or Los Angeles or New York or Phoenix or San Francisco or Seattle
$125k-$186k/yr OnsiteFull Time
8+ YOE8+ years software engineering; expert Python; strong AWS; data modeling; LLM evaluation; experience with agentic systems and enterprise AI patterns; Bachelor's in CS/Engineering or equivalent.
Python, AWS, SQL, LLM, Dataiku, OpenAI
1mo
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Senior Firmware Engineer
Boulder, Colorado, United States
$150k-$200k/yr OnsiteFull Time
Embedded firmware development for ARM-based MCUs; C, Python; drivers (SPI, RS-232, CAN, Modbus); debugging and problem solving; degree in EE/CS or equivalent experience.
STM32 ARM MCU, SPI, RS-232, CAN, Modbus, JTAG, ARM assembly, Python, C, Linux, TensorFlow, CUDA
3w
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Senior Sales Engineer
Chicago or Westminster or Wakefield or Boston or New York or Irving
$147k-$273k/yr HybridFull Time
15+ YOE15+ years in pre-sales or sales engineering; proven success with complex enterprise deals; strong client presence at senior levels; ability to navigate technical and business discussions; proficient in SQL, Python, APIs, data pipelines, and cloud infrastructure.
SQL, Python, APIs, Data Pipelines, Cloud Infrastructure
5d
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Senior Software Engineer I
Denver or New York City or San Francisco
$189k-$200k/yr HybridFull Time
5+ YOE3–5+ years in OO languages (TypeScript, C#, Java); Python for data tasks; React/Tailwind; data architectures; private markets data; CI/CD, data orchestration; cloud (AWS/Azure/GCP); Git/GitHub; Agile tools (JIRA).
TypeScript, C#, Java, Python, React, TailwindCSS, Medallion, Data lakes, CI/CD, PostgreSQL, SQL, AWS, Azure, GCP, Git, GitHub, JIRA
3mo
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Senior Java Software Engineer (Onsite)
State College or Fort Meade or Aurora
$87k-$165k/yr OnsiteFull Time
5+ YOEActive TS/SCI with Polygraph; 5+ years STEM software experience; Java in Linux; scripting (Perl/Python); Agile/DevOps.
Java, Linux, JUnit, Perl, Python, Agile, DevOps, Jenkins, Ansible, Spring, Containers, Git, SQL, Scripting
2mo
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Senior Spacecraft Software Engineer
Boulder or Glasgow
$131k-$171k/yr HybridFull Time
Spire Global: Operates a satellite constellation providing data and global analytics.
Proficient in C++ or Python; FPGA development; DSP; GNSS signal processing; cloud-based systems; strong software engineering skills.
C++, Python, FPGA, VHDL, HLS, DSP, GNSS, AWS
2mo
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Senior Software Engineer
Aurora, Colorado, United States
$170k-$260k/yr OnsiteFull Time
14+ YOEActive TS/SCI with Polygraph; U.S. Citizenship; 14+ years software engineering experience and Bachelor's in Computer Science; strong independent and team work; excellent communication.
Python, AWS ML, Kubernetes, Docker, AI tools
2mo
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Senior Platform Engineer
Arvada or Los Angeles or San Francisco or Seattle or Washington
$145k-$186k/yr HybridFull Time
3+ YOE3+ years in reliability, systems, DevOps, infrastructure, or platform engineering; Bachelor's degree; ability to obtain security clearance; ITAR eligibility.
Kubernetes, Terraform, Python, New Relic, DataDog, Splunk, AWS CloudWatch, GitHub Actions, Auth0, Okta, Git, VPN, NLB/ALB, TLS, CDN
1mo
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Senior Full-Stack Engineer
Denver, Colorado, United States
RemoteFull Time
Senior-level full-stack engineer with Python and Ruby on Rails backend, experience securing systems, integrating generative AI tools, and implementing AI/ML workflows for enterprise SaaS.
Python, Ruby on Rails, OpenAI APIs, LangChain, Hugging Face, Pinecone, Weaviate, React, Vue, Okta, Snowflake, LangChain, GPT
1mo
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Senior Software Engineer (Big Data)
Westminster, Colorado, United States
$89k-$165k/yr OnsiteFull Time
5+ YOE5+ years in distributed software development; Scala/Python/Java; Spark; AWS; Databricks; SQL; ETL/data pipelines; mentoring.
Python, Scala, Java, Apache Spark, Hadoop, Hive, AWS, Databricks, Kubernetes, Docker, Airflow, ELK, Git, SQL
HiringCafe market data
Senior Python Developer Jobs market signals in Centennial, CO, US
These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.
Open jobs
660+
Hiring companies
210+
Fresh sample
54% new in 30d
Salary visibility
81% show pay
Companies appearing in this market
Booz Allen HamiltonCableLabsAltamira TechnologiesAppleBAE SystemsEchoStarForge GlobalLockheed Martin
Work location mix in visible results
Onsite: 57Hybrid: 36Remote: 8