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Senior Python Software Engineer Jobs in United States
9,500+ senior python software engineer jobs from 2,600+ companies hiring in United States.
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Senior Software Engineer (Python)
Columbia, Maryland, United States
$170k-$240k/yr OnsiteFull Time
12+ YOESenior software engineer with 12+ years exp, Python expert, production apps, AI concepts, Kafka, Elasticsearch; TS/SCI with polygraph.
Python, Kafka, Elasticsearch, PydanticAI, LangGraph
2mo
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Senior Python Software Engineer
Linthicum Heights, Maryland, United States
$170k-$260k/yr OnsiteFull Time
6+ YOEActive TS/SCI with Polygraph clearance; U.S. citizenship; 6+ years software engineering with MS in CS (or 8+ years with BS), or 10+ years with AA, or 12+ years with high school diploma; strong communication and independent work skills.
Python, Docker, Django, Flask, MongoDB, MariaDB, REST, JSON, XML, Jira, Confluence, Git, AWS
1w
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Sr Staff / Senior Python Software Engineer
Boulder, Colorado, United States
$126k-$175k/yr OnsiteFull Time
6+ YOEBachelor’s degree in CS/Engineering/Math/Physical Sciences; 6+ years of professional Python software engineering; microservices and distributed systems; real-time data processing pipelines; automated testing; Linux; Git; DoD clearance; strong communication.
Python, Linux, Docker, Git, pytest, CI/CD, Microservices, Distributed Systems, REST APIs, protobuf, ZeroMQ, Kafka, gRPC
2mo
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Senior Software Engineer - Python
United States
$180k/yr RemoteFull Time
5+ YOE5+ years software engineering; expert in Go/Python/Java; strong DB and data modeling; cloud, microservices; CI/CD; agile; leadership.
Go, Python, Java, PostgreSQL, MySQL, Spring, Flask, Docker, Kubernetes, AWS, CI/CD
2mo
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Python Software Engineer
Dallas, Texas, United States
$70-$90/hr OnsiteFull Time
7+ YOE7–10+ years software development experience; proficient in Python; experience with Azure Functions, APIs, event-driven architectures; cloud, AI/ML exposure.
Python, C#, TypeScript, Azure Functions, APIs, API Management, Azure Event Grid, Durable Functions, LangChain, AutoGen, Semantic Kernel
3w
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Senior Python Engineer
United States
$200k-$225k/yr RemoteFull Time
5+ YOE5+ years backend software engineering; strong Python; API design; production ML/AI experience; cloud platforms; Docker/Kubernetes.
Python, AWS, GCP, Azure, Docker, Kubernetes, SQL, NoSQL, LLMs, ML
2w
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Python Software Developer
Ashburn, Virginia, United States
HybridFull Time
4+ YOE4+ years software development; Python proficiency; strong SQL; GraphQL APIs; REST; Git/Linux/Docker; web security; cloud; microservices; bachelor's degree or equivalent; authorized to work in the United States
Python, GraphQL, REST, SQL, Git, Linux, Docker, OpenAPI
3w
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Senior Software Engineer - Python
New York, New York, United States
OnsiteFull Time
Strong Python development, data engineering, ETL, and SQL expertise; experience with cloud data platforms and data reconciliation.
Python, Informatica, Snowflake, Redshift, BigQuery, SQL, Shell, Bash, PowerShell
5d
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Senior Software Engineer -Python
Salt Lake City, Utah, United States
$140k-$217k/yr OnsiteFull Time
6+ YOESix years software development experience; BS in CS or related; Python, REST, JavaScript/Angular/React; experience with databases and integrating third-party products.
Python, REST, JavaScript, Angular, React, AWS, Kafka, Django, JIRA, Git, IntelliJ, VS Code
2mo
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Sr Software Engineer Python
San Jose or Austin
$144k-$213k/yr HybridFull Time
3+ YOESenior backend Python engineer with 4+ years, strong Django/Flask, OAuth2, REST, databases; may require Bachelor's or equivalent.
Python, Django, Flask, OAuth2, REST, Git, SQL, NoSQL
3w
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Python Software Engineer
Atlantic City, New Jersey, United States
$79k-$123k/yr OnsiteFull Time
6+ YOEDesign and implement Python automation solutions, automation frameworks, CI/CD integration, and validation for complex systems.
Python, Jenkins, Ansible, SaltStack, Terraform, Selenium, Playwright, Bash, Linux
2w
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Senior Python Developer
Egg Harbor Township, New Jersey, United States
$100k-$155k/yr OnsiteFull Time
9+ YOESenior Python developer with 9+ years, strong in messaging systems, REST/microservices, async, QA, Agile.
Python, Messaging brokers, REST APIs, Docker, Kubernetes, Cloud platforms, Oracle/SQL/NoSQL, Java, Go, CI/CD, Agile tooling (JIRA)
4d
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CNO Python Software Engineer
Hanover, Maryland, United States
OnsiteFull Time
7+ YOEBachelor’s in CS or related field with 7 years programming, or 11 years experience; Python; Docker; Kubernetes; Ansible; CI/CD; Windows and Linux; security clearance TS/SCI w/ Poly; experience with SQL/NoSQL; software testing and deployment.
Python, Docker, Kubernetes, Ansible, CI/CD, VMware, Java, SQL, NoSQL, Git, Subversion, Confluence, Jira, Crucible
1mo
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Backend Senior Lead Software Engineer- Python
Jersey City, New Jersey, United States
$171k-$260k/yr OnsiteFull Time
5+ YOESenior lead software engineer with 5+ years of Python experience, enterprise platforms, cloud-native tech, and agile development.
Python, Cloud technologies, Enterprise software, Agile methodologies, Code review, Software development lifecycle
1mo
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Senior Software Engineer II Python
United States
HybridFull Time
8+ YOE8+ years in software development; expert in Python; experience with ML/AI frameworks; containerization and cloud platforms; healthcare domain knowledge is a plus.
Python, PyTorch, TensorFlow, Hugging Face, LangChain, Haystack, LlamaIndex, Pinecone, Weaviate, MLflow, Weights & Biases, Azure Machine Learning, Azure OpenAI, AWS SageMaker, GCP Vertex AI, ONNX Runtime, TensorRT, Robot Framework, PyTest, TestGPT, Apache Spark, Airflow, SQL, NoSQL, Kubernetes, Docker, React, Next.js, FastAPI, Django, Kafka
1mo
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Senior AI Python Software Engineer (Perm, Canada, Remote + Travel)
Canada or United States
RemoteFull Time
8+ YOESenior engineer with 8+ years experience, Python expertise, AI frameworks, agile delivery, cloud/databases, CI/CD, and strong collaboration.
Python, Git, Kubernetes, LangGraph, Agentspace, React, CI/CD
2w
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Senior Backend Python Engineer
Redmond, Washington, United States
$135k-$180k/yr OnsiteFull Time
5+ YOESenior backend Python engineer with 5+ years in DevOps/Data Engineering/AI infra; strong Python, backend APIs, data pipelines, and integrations; familiar with Prefect, Kubernetes, REST/JSON, HTML scraping, and CI/CD.
Python, FastAPI, Flask, Django REST, Prefect, Kubernetes, Splunk, REST/JSON, HTML scraping, CI/CD, SQL, NoSQL
4w
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Senior Software Engineer - Python and Data Ecosystem
United States or Canada or United Kingdom or Portugal or Spain or France or Italy or Germany or Netherlands or Poland or Czech Republic or Israel
RemoteFull Time
7+ YOE7+ years software development experience; strong Python connectors; experience with orchestration/tools; AI/ML in data engineering; SQL/OLAP; async in Python.
Python, Pandas, NumPy, Pydantic, Airflow, Dagster, Prefect, dbt, SQLMesh, LangChain, LlamaIndex, n8n, ClickHouse
1w
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Senior Software Engineer - Django/Python
North Little Rock or Phoenix
RemoteFull Time
5+ YOE5-10+ years designing software architecture; extensive Django/Python web app/API experience; PostgreSQL; REST APIs; Docker; CI/CD; GitHub Actions; AWS/Azure; Terraform; observability; mentoring.
Django, Python, PostgreSQL, REST API, Django REST Framework, Celery, Flower, GitHub, Docker, CI/CD, GitHub Actions, AWS, Azure, Terraform, Vue 3, JavaScript, HTML5, CSS3
2w
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Senior Python Developer
United States
$68k-$132k/yr RemoteFull Time
6+ YOE6+ years Python development; strong PySpark, SQL, Airflow; cloud experience (GCP or Azure); design of large-scale, high-volume analytics/data engineering solutions; collaborative cross-functional work.
Python, PySpark, SQL, Airflow, Google Cloud Platform, Azure, BigQuery, Power BI, Looker Studio, Scala
1w
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Senior Software Engineer - Python - AI Platform
United States
HybridFull Time
Senior software engineer with strong backend experience, proficiency in multiple languages, system design, and ability to mentor others. Willing to lead on-call and production support, contribute to architecture, and drive process improvements.
Python, Java, JavaScript, React, Node, PHP, MySQL, GraphQL, Docker, AWS, Kotlin, Xcode, Swift
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Senior Python Engineer
San Francisco, California, United States
$126k-$248k/yr HybridFull Time
Strong Python software development experience; practical AI/ML framework knowledge in Python; open source contribution; strong communication; mentoring; self-motivated with time management.
Python, AI/ML frameworks, LangChain, PyMongo, Django, Web development frameworks, Open source tooling
3w
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Senior Python Core Engineer
United States
$187k-$259k/yr RemoteFull Time
5+ YOE5+ years software engineering; deep Python production experience; strong Python build tooling; containerized environments; maintain shared libraries; on-call rotation; collaboration with CI/CD and data/ML teams.
Python, Docker, CI/CD, versioning, dependency management, APIs, library development
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Senior Python Software Engineer
Dallas, Texas, United States
HybridFull Time
5+ YOE5+ years software development experience in Python; working knowledge of .NET (C#); design/consumption of REST APIs; cloud exposure (Azure/AWS); front-end basics (React/Angular); CI/CD; healthcare domain familiarity a plus.
Python, Django, Flask, FastAPI, .NET (C#), REST, React, Angular, Azure, AWS, CI/CD, Azure DevOps, GitHub Actions, PyTest, xUnit, Jest, SQL
1mo
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Backend Senior Lead Software Engineer- Python
Jersey City, New Jersey, United States
$171k-$260k/yr OnsiteFull Time
5+ YOEBachelor's in CS/Engineering/Math or related field; 5+ years software engineering; enterprise software experience; strong Python; cloud-native and SDLC experience.
Python, Cloud
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Senior Software Engineer - Python APIs
Jersey City or Westlake
$97k-$185k/yr HybridFull Time
5+ YOE5+ years Python cloud app development; strong Python, AWS, CI/CD, Docker; distributed systems; ML platform experience; sponsorship not provided.
Python, AWS, S3, Lambda, Batch, Step Functions, EventBridge, CloudWatch, SNS, SQS, Jenkins, Docker, Terraform, CloudFormation, OpenTofu, SageMaker
3w
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Senior Software Engineer - Robotics, Perception (C++, Python)
Columbus, Ohio, United States
OnsiteFull Time
5+ YOE5+ years in software engineering; strong C++/Python; experience with ROS/ROS2 and deployment of production services using gRPC/Protobuf.
C++, Python, gRPC, Protobuf, ROS/ROS2, Docker, Linux
1w
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Senior Software Engineer
Owings Mills, Maryland, United States
$121k-$206k/yr HybridFull Time
5+ YOESenior software engineer with AWS, Amazon Connect, Java/Python, CI/CD, Docker, OAuth2, and distributed systems.
Java, Python, Amazon Connect, AWS, Lambda, Lex, DynamoDB, S3, Git, Docker, OAuth2, OIDC, JWT, ADFS, Terraform
2mo
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Senior Software Engineer
Palo Alto, California, United States
$175k-$186k/yr OnsiteFull Time
Senior firmware/software engineer with C++, Linux, Python; experience with embedded systems, UI/UX, and multimedia pipelines.
C++, Linux, Python, Qt, QML, GStreamer, Embedded Linux
2w
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Senior Software Engineer
West Palm Beach, Florida, United States
HybridFull Time
Senior software engineer with defense software experience, embedded and ROS2, MAVLink, ATAK/WinTAK; strong C++/Python and secure CI/CD practices.
C++, Python, ROS 2, MAVLink, ATaK, WinTAK, DDS, RTI Connext, CycloneDDS, FastDDS, NVIDIA Jetson, ArduPilot, PX4, Git, CI/CD, Jenkins, GitHub Actions, ROS 2
1mo
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Senior Software Engineer
O'Fallon, Missouri, United States
$115k-$184k/yr OnsiteFull Time
5+ YOEHands-on senior software engineer with Fraud Rules Engines, multiple languages (Java, Python, Go), AI/ML knowledge, and large-scale migrations.
Java, Python, Go, Fraud Rules Engine, AI/ML, Relational Databases, NoSQL, LLMs
3w
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Senior Software Engineer
United States
$100k-$130k/yr RemoteFull Time
5+ YOESenior software engineer to design and deliver AI-enabled data platforms; strong Python; PostgreSQL; cloud; microservices; leadership.
Python, Elixir, Golang, PostgreSQL, REST APIs, Kubernetes, Docker, Terraform, CloudFormation
1mo
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Senior Software Engineer
United States
$107k-$221k/yr RemoteFull Time
5+ YOESenior software engineer with 5+ years of experience; strong containerization knowledge; Python; IaaS tools; distributed systems experience.
Kubernetes, Docker, Python, Ansible, Terraform, SaltStack, Virtualization, Distributed systems, Filesystems
2mo
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Senior Software Engineer
Newark, New Jersey, United States
$104k-$172k/yr HybridFull Time
Senior Software Engineer with extensive software development experience across Java, Python, and React; cloud, DevOps, and Agile practices; strong problem-solving and collaboration.
Java, Python, React, FAST, Springboot, Boto3, pandas, urllib3, Docker, Terraform, CloudFormation, DynamoDB, Bedrock, Textract, ECS, Lambda, S3, RDS, Node.js, HTML, CSS, JavaScript, Kubernetes, GitHub, Bitbucket, Jenkins, AWS, Azure, GCP, APIs, Kong, Apigee, API Gateway, DevOps, CI/CD
1mo
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Senior Python Developer
Fairfax, Virginia, United States
OnsiteFull Time
7+ YOEStrong Python, Elastic Stack, 7-9+ years building enterprise apps, systems integration, CI/CD, data modeling, and distributed storage tech.
Python, Pandas, BeautifulSoup, NumPy, Boto3, Elasticsearch, Kibana, Docker, Kubernetes, AWS, Git, CI/CD, RabbitMQ, Kafka, Logstash, Beats, Splunk, Terraform
1w
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Senior, Software Engineer
Bentonville, Arkansas, United States
$90k-$180k/yr OnsiteFull Time
3+ YOESenior software engineer with Java/Python, data engineering, cloud, and microservices; 3+ years experience; Bachelor or Master with related fields; leadership and mentoring abilities.
Java, Python, Machine Learning, Microservices, SQL, NoSQL databases, BigQuery, CosmosDB, Cassandra, Postgres, Kafka, Cloud platforms, Hadoop, Hive, Spark
1w
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Senior Software Engineer - Python - AI Platform
United States
$124k/yr OnsiteFull Time
5+ YOE5+ years software development; Python & SQL proficiency; cloud, microservices, Terraform, CI/CD; strong collaboration and communication; able to own services end-to-end.
Python, SQL, GCP, Vertex AI, Kubernetes, Kafka, Terraform, CI/CD, Git, Jira, Confluence, REST API
1mo
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Python Software Engineer (TS/SCI with Polygraph)
Annapolis Junction, Maryland, United States
$150k-$200k/yr OnsiteFull Time
7+ YOE7+ years software engineering; BS in CS or related field; Linux CLI; Bash; Python; Rust or willingness to learn; NoSQL (MongoDB); Docker; Kubernetes; Helm; RabbitMQ; GitLab CI; Ansible; Git; TS/SCI with polygraph
Linux, Bash, Python, Rust, MongoDB, Docker, containerd, Kubernetes, Helm, RabbitMQ, GitLab CI, Ansible, Git, PostgreSQL, Jira, Confluence
1mo
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Senior Software Engineer
Huntsville, Alabama, United States
RemoteFull Time
7+ YOESenior software engineer with 7+ years of experience; DoD clearance; Java and Python; Docker, Kubernetes; Linux/Windows; GitLab; modeling and simulation.
Java, Python, Docker, Kubernetes, Linux, Windows, GitLab
2mo
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Python Senior Developer
Tampa, Florida, United States
$97k-$145k/yr HybridFull Time
3+ YOE3-5 years hands-on application development; 3+ years Python; REST APIs, FASTAPI; Airflow; Kafka; S3; SQL Server/Oracle; Docker; EKS; Grafana/OpenTelemetry; strong problem solving and communication.
Python, REST APIs, FASTAPI, Apache Airflow, Apache Kafka, Amazon S3, SQL Server, Oracle, Docker, Amazon EKS, OpenTelemetry, Grafana, Trino, Starburst, Pinot, Spark
HiringCafe market data
Senior Python Software Engineer Jobs market signals in United States
These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.
Open jobs
9,500+
Hiring companies
2,600+
Fresh sample
45% new in 30d
Salary visibility
71% show pay
Companies appearing in this market
JPMorgan ChaseAlvarez & MarsalASRC FederalChimeCitiClickHouseCognizantECS
Work location mix in visible results
Onsite: 67Hybrid: 33Remote: 24