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Staff Python Software Engineer Jobs in Lowell, MA, US
55 staff python software engineer jobs from 38 companies hiring in Lowell, MA, US.
2mo
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Staff Software Engineer- Python
Boston, Massachusetts, United States
OnsiteFull Time
8+ YOE8+ years Python/OO, SQL, Git; experience with React/JS, TypeScript; cloud (AWS/Azure/GCP), Terraform/Pulumi; Docker; Bachelor’s degree.
Python, JavaScript, TypeScript, React, Node, Flask, Docker, Terraform, Pulumi, AWS, Azure, GCP, SQL
1w
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Staff Software Engineer
Cambridge or New York
$200k-$325k/yr HybridFull Time
10+ YOE10+ years software engineering; healthcare data systems; 2+ years in a high-growth startup; strong system integration; ML/AI tooling; data pipelines; backend with Python/SQL; production ML infrastructure.
Python, SQL, Cloud Infrastructure, EHR/EMR integrations, AI tooling
4d
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Staff Software Engineer
Boston, Massachusetts, United States
$147k-$215k/yr HybridFull Time
8+ YOE8–10+ years in software development, system validation, or automated testing for distributed or embedded systems; strong software architecture and design; Python proficiency; proven leadership.
Python
6d
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Staff Software Engineer
Boston, Massachusetts, United States
$155k-$180k/yr OnsiteFull Time
12+ YOESenior software engineer with extensive full-stack and backend experience leading complex systems.
C#, .NET, Python, SQL Server, SQLite, Azure, AWS, Google Cloud, Docker, Azure DevOps
1mo
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Staff Software Engineer
Boston, Massachusetts, United States
HybridFull Time
8+ YOEBS in Engineering/CS; 8+ years product software development; 5+ years medical device R&D; strong OO design, C++11+, C#/WPF MVVM; Python/PowerShell; Git, CI; UX, cybersecurity; IEC 62304/ISO13485/FDA guidance; excellent communication
C++, C#, WPF, MVVM, Python, PowerShell, Git, CI, GPU programming, Image processing, Deep Learning, Convolutional Neural Networks, AI techniques, DevOps tools, JIRA
2w
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Staff Software Engineer
Waltham or North Bethesda
$160k-$180k/yr HybridFull Time
5+ YOE5+ years in software/ML roles; Bachelor’s in CS or related field; strong cloud, IaC, Python; AWS experience; AI/ML infrastructure knowledge.
Terraform, Python, AWS, SageMaker, Kubernetes, Docker, IAM, Lambda, CloudWatch, ECR, EKS, Kinesis
2mo
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Staff Software Engineer
Evendale or Lynn
$109k-$146k/yr OnsiteFull Time
5+ YOEBachelor's in CS/CE/EE; 5+ years software engineering for complex systems; US citizenship and ability to obtain US government security clearance.
C/C++, Python
1mo
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Staff Software Engineer- Hardware Validation
Mountain View or Boston
$160k-$200k/yr HybridFull Time
12+ YOELead development of scalable HTOL test software; strong Python, containerization, CI/CD; hardware integration experience.
Python, FastAPI, Flask, Django, Docker, Docker Compose, MongoDB, PostgreSQL, Redis, Time-series databases, pytest, GitHub Actions, Ansible, BMCs, FPGAs
3w
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Staff Engineer Robotics Software
Boston, Massachusetts, United States
$146k-$204k/yr HybridFull Time
10+ YOESenior robotics software engineering leader with 10+ years in software architecture and distributed systems; strong programming skills.
C, C++, Python, JavaScript, Go
3w
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Staff Software Engineer
Waltham, Massachusetts, United States
$134k-$168k/yr OnsiteFull Time
4+ YOE4+ years real-time Linux OS development; strong Linux kernel knowledge; C/C++, Golang, Python; IPC/concurrency; Jira/Git; BS/MS in CS/CE or equivalent
Jira, Git, GitHub, Linux
2mo
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Senior Staff Software Engineer
Boston or Brooklyn or San Francisco or Washington
$225k-$265k/yr HybridFull Time
12+ YOE12+ years backend or data-driven software; cloud deployments; lead engineers; strong communication; ownership of architecture and delivery.
Python, TypeScript, SQL, Docker, Git, Kubernetes, FastAPI, AWS, Azure, MLFlow, Temporal, Postgres, Databricks, OpenSearch
2mo
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Staff Engineer, Software Systems (R4445)
San Diego or Dallas or Washington, D.C. or Boston
$140k-$210k/yr OnsiteAll Commitments Available
5+ YOE5+ years systems engineering or related experience; BS in STEM; MBSE experience; software experience in C++/Python; able to obtain US security clearance.
C++, Python, MBSE, SysML, UML, Cameo
3mo
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Staff Backend Software Engineer
San Francisco or New York or Boston or Denver
$202k-$238k/yr HybridFull Time
Backend engineer with experience in building APIs, data models, and services; strong knowledge of databases, query optimization, and distributed systems; comfortable integrating third‑party vendors; stack includes TypeScript/React, Python/Flask/SQLAlchemy, Kubernetes, AWS.
TypeScript, React, Python, Flask, SQLAlchemy, Kubernetes, AWS
1mo
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Staff Engineer
Boston, Massachusetts, United States
$200k-$230k/yr HybridFull Time
15+ YOE15+ years as software engineer; 2+ years as staff engineer; Master’s in CS; distributed systems; Python; microservices; PostgreSQL; Linux; AI coding tools; React; AWS; Kubernetes; Docker; GitHub Copilot; mentoring experience.
Python, PostgreSQL, Linux, GitHub Copilot, React, AWS, Kubernetes, Docker, TypeScript, Node.js
1mo
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Staff Software Engineer, Application Services
Westborough, Massachusetts, United States
$137k-$261k/yr HybridFull Time
10+ YOE3+ Mgmt10+ years in large-scale software, 3+ years leading technical teams; strong C/C++, Linux, networking; experience with distributed systems and Agile.
C/C++, Linux, Networking, DPDK, Multi-threading, Python, Unit/Integration Testing, CI/CD, DZ
3w
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Staff Software Engineer - Amazon Connect REMOTE
Frisco or Overland Park or Danbury or Franklin or Coral Gables or Tampa or Alpharetta or King of Prussia or Chicago or Boston or Birmingham or New York City or Lake Mary or Charlotte or Houston or Sunrise or Hartford or San Antonio or Alexandria or Independence or Hunt Valley
$116k-$174k/yr RemoteFull Time
8+ YOE8+ years in software development and cloud computing; extensive AWS experience; AWS certification required; Bachelor's degree in CS/IT or related field.
AWS, Amazon Connect, AWS Lambda, API Gateway, DynamoDB, EventBridge, CloudWatch, SQS, KMS, S3, Terraform, Node.js, Python, Java
2w
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Staff Software Engineer, Data Platform
Berkeley or Somerville
$148k-$194k/yr OnsiteFull Time
8+ YOE8+ years in software or data engineering; strong Python/SQL; experience with FastAPI/Flask, dbt, Dagster, PySpark; proficient with Git and AWS (S3, EC2, RDS); solid SDLC knowledge; experience with OLAP/time-series DBs (Snowflake, Databricks DBSQL, ClickHouse, InfluxDB).
Python, SQL, FastAPI, Flask, dbt, Dagster, PySpark, Git, AWS S3, AWS EC2, AWS RDS, Snowflake, Databricks DBSQL, ClickHouse, InfluxDB
1w
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Staff Software Engineer - Applied AI
Boston, Massachusetts, United States
$175k-$250k/yr RemoteFull Time
Bachelor’s or Master’s in CS/Engineering; backend engineer with Python (Ruby/Go a plus); design scalable APIs; cloud and AI ecosystem knowledge.
Python, Ruby, Go, AWS, Snowflake, OpenAI, Claude, Hugging Face, Langchain
2mo
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Staff Embedded Software Engineer
Waltham, Massachusetts, United States
$150k-$170k/yr OnsiteFull Time
8+ YOEDesign, develop, and optimize embedded firmware; lead firmware architecture; collaborate across teams; 8+ years experience; C/C++/assembly; hardware familiarity; travel <10%.
C/C++, Assembly, Git, Python, Bash, Oscilloscope, Logic Analyzers, Debuggers, SPI, I2C, UART, Microcontrollers, Bare-metal, RTOS
1mo
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Staff Software Engineer, AI Lab Execution System
Cambridge or San Francisco
$192k-$238k/yr HybridFull Time
4+ YOE4-6 years of building large-scale systems; strong in front-end or back-end or data modeling; React, TypeScript, Python; experience with SQL/NoSQL/Vector DBs; API design; life sciences or data-intensive domains; excellent cross-functional collaboration.
React, TypeScript, Python, SQL, NoSQL, Vector DBs, AWS, Kubernetes, Terraform, CloudFormation, GitHub Actions, Flyte, Temporal, Airflow, Prefect
1w
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Staff Software Engineer
Rome or Hanscom AFB or Washington
$140k-$190k/yr HybridFull Time
3+ YOE3+ years DOD industry experience; Docker & Kubernetes; data platforms; AWS; CI/CD; GitOps; Security+ within 90 days; ability to obtain Secret clearance; travel up to 25-35%.
Docker, Kubernetes, Kafka, Pinot, Flink, AWS, GitLab, Helm, Terraform, Ansible, Prometheus, Grafana, Fluentbit, Kibana, Loki, Istio, Maven, Gradle, NPM, Yarn, Python, Go, GitLab Runners
1mo
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Senior Software Engineer Staff/Avionics
North Andover, Massachusetts, United States
OnsiteFull Time
Bachelor's degree in Computer Science or related field; C++ or Python experience; ability to obtain DoD Secret clearance.
C++, Python, Software Development Tools
1mo
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AI Staff Engineer
Boston, Massachusetts, United States
OnsiteFull Time
5+ YOE5+ years shipping software; hands-on LLM experience; Python, React, TypeScript; AI agent frameworks; Anthropic Claude or AWS Bedrock; AWS services; leadership experience; startup velocity; strong communicator.
Python, React, TypeScript, Anthropic Claude, AWS Bedrock, LangChain, Griptape, Lambda, DynamoDB, SQS, EventBridge, APIGateway, Playwright, GraphQL
2mo
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Staff AI Agent Engineer
Boston or Berkeley
HybridFull Time
6+ YOE6+ years software engineering; Python; backend; LLMs; customer-facing; strong ownership.
Python, APIs, Cloud, LLMs, Agent Frameworks
2mo
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Staff AI Engineer - Notebooks
Boston or New York or Remote
$234k-$300k/yr HybridFull Time
10+ YOE10+ years engineering, technical lead experience; ML/AI focus; BS/MS/PhD in a scientific field or equivalent; experience deploying and evaluating ML models; product-driven mindset.
Python, Machine Learning, TensorFlow, PyTorch, ML tooling
4d
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AI Staff Engineer (SW Engineer IV+)
Philadelphia or Boston or New York City or Baltimore or Washington D.C. or Charlotte or Raleigh-Durham or Atlanta or Chicago
$170k-$220k/yr HybridFull Time
8+ YOE8+ years software engineering; experience with Python/JS/TS; data pipelines; AI/ML production; cloud-native systems (AWS); strong cross-functional collaboration.
Python, JavaScript/TypeScript, AWS, Databricks, Spark, Snowflake, AI/ML
1w
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Staff Software Engineer
Wakefield, Massachusetts, United States
$121k-$224k/yr OnsiteFull Time
Proven experience building production distributed systems; strong backend in Java; Spark data tooling; cloud experience (AWS/Azure/GCP); leadership in design reviews and standards.
Java, Apache Spark, Databricks, Kubernetes, Docker, Airflow, AWS, Azure, GCP, PostgreSQL, Scylla, Python
2mo
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Senior Software Engineer-Technical Staff (Lexington, MA, US)
Lexington, Massachusetts, United States
$145k-$220k/yr OnsiteFull Time
3+ YOEPhD in computer engineering or computer science or related field; 3-5 years lead experience; strong problem-solving, communication; experience with modern, modular architectures; programming in C/C++, Java or Python, and Bash.
C/C++, Java, Python, Bash, HDL
11h
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Staff Machine Learning Engineer (Health)
Boston, Massachusetts, United States
$170k-$230k/yr OnsiteFull Time
7+ YOE7+ years in ML or software engineering building production ML systems; strong Python; experience with time-series data, cloud (AWS or GCP), CI/CD, and regulated environments.
Python, AWS, GCP, CI/CD, Observability, Backend APIs
4d
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Senior / Staff Software Engineer, Data Infrastructure
Boston or New York City
$222k-$288k/yr OnsiteFull Time
5+ YOE5-7+ years in software/data engineering; Python; AWS data services; Snowflake; Dagster/Airflow; dbt; Terraform; data warehousing and pipelines.
Python, AWS (Kinesis, Firehose, Lambda, S3, Glue), Snowflake, Dagster, Airflow, dbt, Terraform
1w
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Staff Platform Engineer
Boston, Massachusetts, United States
$183k-$227k/yr OnsiteFull Time
8+ YOE8+ years software engineering; 4+ years Kubernetes at scale; strong AWS, CI/CD, IaC (Terraform/CloudFormation); programming in Python/Java/Go/JavaScript; cloud security and monitoring expertise; excellent communication.
AWS, Kubernetes, Terraform, CloudFormation, GitHub Actions, ArgoCD, Argo Workflows, Jenkins, CircleCI, Grafana, CloudWatch, Prometheus, Terraform
2mo
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Staff AI Systems Engineer
United States or New York City or Boston or Chicago or Denver or Los Angeles or San Francisco or Austin
$200k-$225k/yr RemoteFull Time
5+ YOE5+ years building and shipping ML systems; strong backend Python/JS; experience with LLM agents, ML platforms, cloud infra; observability and evals; remote work capable.
LangChain, LangGraph, vLLM, OpenAI API, Gemini API, Anthropic API, MCP, Postgres, Redis, Prometheus, Grafana, OpenTelemetry, LangSmith, Langfuse, TensorRT, PyTorch, Kubernetes, Terraform, Express, FastAPI, REST, SSE, JWT, AWS
1w
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Staff Front End Engineer
Boston or Las Vegas or Pittsburgh or Remote U.S. Only
$172k-$229k/yr HybridFull Time
5+ YOEStrong React, TypeScript, and Vue; frontend architecture; collaboration with ML and data teams; ownership and mentoring; UX focus.
React, TypeScript, Vue, Node, Python
1w
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Senior Staff Engineer Digital IC Build Flow and Methodology
Westborough or Austin or Santa Clara
$151k-$223k/yr OnsiteFull Time
8+ YOEDesign, implement, and maintain scalable build flows for digital IC; 8+ years ASIC/SoC experience; strong Python and scripting; EDA/toolchain familiarity.
Python, TCL, C++, Shell, Make, Bazel, EDA tools
1w
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Sr. Staff AI/ML Engineer
Portland or San Francisco or Chicago or Boston or Seattle or Dallas
$220k-$256k/yr RemoteFull Time
12+ YOELead development of production AI systems; 12+ years in software/ML; Python, PyTorch/TF; cloud platforms; IaC; CI/CD; Bachelor's (Master preferred).
Python, PyTorch, TensorFlow, NumPy, Pandas, scikit-learn, LangChain, ADK, AWS, Azure, GCP, Terraform, GitHub Actions
1mo
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Staff Computational Biologist
Lexington or United States
$166k-$195k/yr HybridFull Time
6+ YOE6+ years in computational biology/data-driven discovery; 1+ year in software/data engineering; Python and R; omics/translational analysis; ETL pipelines; product-owner experience.
Python, R, Omics data analysis, ETL pipelines
3w
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Staff Site Reliability Engineer
Boston, Massachusetts, United States
$180k-$225k/yr HybridFull Time
10+ YOE10+ years in software engineering; infrastructure/platform/reliability focus; proficient in Go/TypeScript/Python/Java; IaC (Terraform/CDK/CloudFormation); SRE tooling; security and IAM; experience with distributed systems.
Go, TypeScript, Python, Java, Terraform, CDK, CloudFormation, SSO/OIDC, RBAC, ABAC, Secrets management, Key management
1w
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Member of Technical Staff - Product Engineer (Internal Data & Agent Platform)
San Francisco or Cambridge or Germany
HybridFull Time
5+ YOE5+ years software engineering; experience building data pipelines, integrations, or internal platforms; hands-on LLM production experience; strong Python; TypeScript for frontend/tooling; experience integrating SaaS APIs.
Python, TypeScript, Slack API, GitHub API, Google Workspace API, HRIS API
HiringCafe market data
Staff Python Software Engineer Jobs market signals in Lowell, MA, US
These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.
Open jobs
55
Hiring companies
38
Fresh sample
52% new in 30d
Salary visibility
85% show pay
Companies appearing in this market
Boston DynamicsMIT Lincoln LaboratoryDatadogGE AerospaceLiberateLightmatterLila SciencesMotional
Work location mix in visible results
Hybrid: 24Onsite: 24Remote: 4