Staff Python Software Engineer Jobs in United States

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Staff Software Engineer- Python

Oaks, Pennsylvania, United States

OnsiteFull Time

RevSpring: Provides patient engagement and payment solutions for healthcare providers.

8+ YOE8+ years OOP with Python; 8+ years SQL; 8+ years Git; Bachelor's; skilled in JS/TS/React/Node/Python; cloud (AWS/Azure/GCP); Docker; security basics.

JavaScript, TypeScript, React, Node, Python, Flask, AWS, Azure, GCP, Pulumi, Terraform, Docker, TCP/IP

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Sr Staff / Senior Python Software Engineer

Boulder, Colorado, United States

$126k-$175k/yr OnsiteFull Time

SciTec: Provides advanced remote sensing and missile defense technology solutions.

6+ YOEBachelor’s degree in CS/Engineering/Math/Physical Sciences; 6+ years of professional Python software engineering; microservices and distributed systems; real-time data processing pipelines; automated testing; Linux; Git; DoD clearance; strong communication.

Python, Linux, Docker, Git, pytest, CI/CD, Microservices, Distributed Systems, REST APIs, protobuf, ZeroMQ, Kafka, gRPC

1mo

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1mo

Staff Software Engineer (AI Infrastructure/Python)

New York, New York, United States

$150k-$170k/yr RemoteFull Time

NBCUniversalNASDAQ: CMCSA: Produces and distributes entertainment content and theme park experiences.

8+ YOE8+ years of full-stack software engineering; strong Python and REST API experience; modern JavaScript (React) expertise; cloud deployment (AWS/Azure/GCP); experience with AI/Generative AI tools and Terraform; agile environment; strong communication.

Python, REST, JavaScript, React, AWS, Azure, GCP, Terraform, APIs, OAuth, Active Directory, Serverless

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Staff Software Engineer

Overland Park, Kansas, United States

RemoteFull Time

WellSky: Healthcare technology providing software for coordinated care delivery.

8+ YOEStaff Software Engineer with 8-12 years of experience; strong C#, Python a plus; AI development experience or willingness to learn; cloud and NoSQL experience.

C#, Python, Google Cloud Platform, AWS, Azure, NoSQL, Claude Code, Gemini

1mo

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1mo

Staff Software Engineer

United States

RemoteFull Time

Medical Home Network: Delivers technology and care models for safety-net healthcare providers.

6+ YOESeeking a Staff Software Engineer to build AI-enabled software with a systems mindset and product orientation.

Python, Java, Angular, DBT, Snowflake

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Software Engineer Staff

Owego, New York, United States

HybridFull Time

Lockheed MartinNYSE: LMT: Designs and manufactures global security and aerospace systems.

5+ YOESenior software engineer with embedded avionics expertise, C/C++, Python, and full software lifecycle experience.

C, C++, Python, Git/GitLab, Visual Studio, Atlassian

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Staff Software Engineer

San Francisco, California, United States

$198k-$331k/yr HybridFull Time

AmplitudeNasdaq: AMPL: Develops digital analytics software for tracking customer product behavior.

Staff-level full-stack engineer with React + Node.js/Python, ownership, product sense, AI tooling experience.

React, Node.js, Python

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Staff Software Engineer, Agents

New York, New York, United States

$231k-$340k/yr HybridFull Time

Harvey: AI platform for legal research and document analysis.

8+ YOE8+ years in software engineering; Python; experience with LLM APIs and agent frameworks; shipping user-facing products; mid to staff levels.

Python, LLM APIs, Agent frameworks

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Staff Software Engineer (Python)

United States

RemoteFull Time

Duetto: Provides revenue strategy software for the global hospitality industry.

7+ YOE7+ years building production data systems in Python; deep PySpark/distributed data processing; lakehouse architectures on AWS; streaming and data quality governance.

Python, PySpark, AWS Glue, Iceberg, Airflow, S3, Athena, Lambda, SQS, Datadog, Sentry, Sumo Logic, Terraform, SageMaker, Trino, Presto, dbt, Great Expectations, Claude Code, GC-LLM tooling

1mo

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1mo

Staff Software Engineer

United States or Canada

$194k-$285k/yr RemoteFull Time

DoorDashNASDAQ: DASH: On-demand delivery platform connecting consumers with local merchants.

8+ YOE8+ years as a software engineer; expert in distributed systems, microservices, internal platforms; strong Python; AWS and Terraform; leads technical initiatives; mentors engineers.

Python, AWS, Terraform, APIs, Microservices, Containers

2mo

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2mo

Staff Software Engineer

Oakland, California, United States

$102k-$207k/yr HybridFull Time

SiriusXMNASDAQ: SIRI: Audio entertainment providing satellite and streaming services.

7+ YOE7+ years software engineering, 2+ years in senior technical leadership; Python backend; distributed systems; AWS/Kubernetes; observability tools.

Python, Django, FastAPI, Kafka, Celery, Airflow, AWS, Kubernetes, Datadog, Sentry, Grafana

1mo

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1mo

Staff Software Engineer

San Francisco or Seattle or New York or Los Angeles

$245k-$290k/yr HybridFull Time

Whatnot: Livestream shopping platform for buying and selling niche products.

8+ YOE8+ years software engineering; leading large initiatives; distributed systems; full-stack (Python/Elixir/JS); strong ownership; mentor engineers; influence architecture.

Python, Elixir, JavaScript

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Staff Software Engineer

Phoenix, Arizona, United States

OnsiteFull Time

Sprouts Farmers MarketNASDAQ: SFM: Grocery retailer specializing in fresh, natural, and organic foods.

8+ YOE8+ years software engineering or 2 years AI/ML; strong Python and ML frameworks; cloud, APIs, data pipelines.

Python, PyTorch, TensorFlow, scikit-learn, AWS, Azure, GCP, APIs, Data pipelines, MLflow, Kubeflow, SageMaker

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Staff Software Engineer

Phoenix, Arizona, United States

OnsiteFull Time

Sprouts Farmers MarketNASDAQ: SFM: Operates a chain of healthy, natural grocery stores.

8+ YOE8+ years software engineering or 2+ years AI/ML; Python; ML frameworks; cloud platforms; APIs; data pipelines.

Python, PyTorch, TensorFlow, scikit-learn, AWS, Azure, GCP, APIs, distributed systems, Data pipelines

2mo

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2mo

Staff Software Engineer

United States

$202k-$253k/yr RemoteFull Time

Omada HealthNASDAQ: OMDA: Provides virtual care and coaching for chronic disease management.

10+ YOE10+ years in software engineering; architecture and performance optimization; Ruby and Python; PostgreSQL/MySQL; batch and streaming pipelines; AWS; CI/CD; Docker/Kubernetes; observability; mentoring.

Ruby, Python, Ruby on Rails, Sidekiq, PostgreSQL, MySQL, SQS, Kafka, Kinesis, Airflow, GraphQL, Django, Docker, Kubernetes, Terraform, Datadog, OpenTelemetry

1mo

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1mo

Staff Software Developer

Poway, California, United States

$128k-$229k/yr OnsiteFull Time

General Atomics Aeronautical Systems: Designs and manufactures unmanned aircraft and radar systems.

8+ YOESenior embedded software engineer with real-time systems, C/C++, Python; DoD Top Secret clearance; 8+ years of experience.

C/C++, Python, RTOS, CANbus, ARINC-429, MIL-STD-1553, SPI, I2C, USART, Ethernet, Git, SVN, Oscilloscopes, Logic Analysers, Power Supplies, Emulators

2mo

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2mo

Staff Software Engineer

New York, New York, United States

$200k-$250k/yr OnsiteFull Time

Tabs: AI-native revenue platform for finance and accounting teams

10+ YOE10+ years of professional software engineering, leading large-scale design, expertise in TypeScript or Python, strong CS fundamentals, and ability to operate in ambiguity and fast pace.

TypeScript, Python

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Staff Software Engineer

Scottsdale, Arizona, United States

OnsiteFull Time

Equity Methods: Provides financial reporting and valuation for equity compensation programs.

8+ YOE8–12 years of software engineering experience; strong in backend services; experience with AWS, Python, and AI workflows; able to work with domain experts; background check required.

Python, Java, Kotlin, Groovy, AWS Lambda, DynamoDB, API Gateway, S3, IAM, Amazon Bedrock, N8N, UI Path, React, Postgres, Snowflake, Elasticsearch, PGVector, Docker

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Staff Software Engineer

San Francisco, California, United States

$180k/yr RemoteFull Time

Swish Analytics: Provides predictive analytics and risk management for sports betting.

6+ YOE6+ years production software engineering and technical leadership; NodeJS & Python; relational and non-relational databases; reliability, observability, and global scale; strong communication; BS or higher in CS/CE/SE.

NodeJS, Python, Kafka, Docker, Kubernetes, Databases, CI/CD

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Staff Software Engineer

Oakland or Atlanta or New York

$107k-$200k/yr OnsiteFull Time

SiriusXMNASDAQ: SIRI: Provides satellite radio and digital audio streaming services.

8+ YOE8+ years of software engineering; strong Python backend; distributed systems and data pipelines; AWS and Kubernetes; observability; cross-team leadership; degree or equivalent; right to work in the U.S.

Python, Django, FastAPI, Celery, Kafka, Airflow, AWS, Kubernetes, Datadog, Sentry, Grafana, CI/CD

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Staff Software Engineer

San Mateo or Las Vegas

$185k-$255k/yr HybridFull Time

Slickdeals: Platform for crowdsourcing and ranking consumer shopping deals.

10+ YOE10+ years software engineering; 7+ years large-scale data solutions; strong SQL/Python/dbt; Databricks, Airflow, AWS experience; data governance and SDLC knowledge.

Databricks, dbt, Airflow, AWS, Tableau, AtScale, SQL, Python

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Staff Software Engineer, Assets

United States or Canada

RemoteFull Time

Webflow: Visual development platform for building professional websites without code.

7+ YOE7+ years software engineering; backend, distributed systems; Python/Java/Go experience.

Python, Java, Go, APIs, Distributed systems

1mo

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1mo

Staff Software Engineer

North America

$145k-$165k/yr RemoteFull Time

Penn Mutual: Provides life insurance and wealth management services to clients.

10+ YOE10+ years software development; BS in CS/Engineering (MS preferred); proficient in Java/C#/Python/JavaScript; UI frameworks; API frameworks; SQL; strong problem-solving and communication.

Java, C#, Python, JavaScript, React, Angular, Django, Flask, Spring Boot, Express, SQL, AWS, Docker, Kubernetes, CloudFormation, Terraform, Jenkins, GitHub Actions, Bamboo

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Staff Software Engineer, Software Systems

San Diego, California, United States

$144k-$175k/yr OnsiteFull Time

Brain Corp: Develops AI software for commercial autonomous mobile robots.

7+ YOE7+ years software engineering; robotics/embedded experience; C++ expert; Python; Linux; HAL/middleware; telemetry; AMRs familiarity.

C++11, C++, Python, Linux, CMake, Google Test, MQTT, Git

1mo

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1mo

Staff Software Engineer

Sioux Falls, South Dakota, United States

OnsiteFull Time

TCOM: Designs and manufactures persistent surveillance aerostat and ISR systems.

6+ YOEBachelor’s degree in software engineering with 6+ years (or Master’s with 6+ years) of experience; proficient in C/C++, Java, Python; experience with JavaScript, Vue, MVC, Go; Unix/Linux; strong problem solving; US Persons required.

C++, Java, Python, JavaScript, Vue.js, MVC, Go, UNIX/Linux

2mo

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2mo

Staff Software Engineer

New York City or San Francisco

OnsiteFull Time

Titan: Modernizes IT services through a proprietary augmented AI platform.

4+ YOE4+ years of software engineering experience; strong Python, Node.js, or Go; cloud experience (AWS/GCP/Azure); knowledge of AI/ML-driven systems or real-time data is a plus; startup mindset.

Python, Node.js, Go, AWS, GCP, Azure, AI/ML

1mo

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1mo

Staff Software Engineer

United States

$140k-$372k/yr RemoteFull Time

GitHubNASDAQ: MSFT: Cloud-based platform for software development and version control.

9+ YOESenior software engineer with 9+ years, strong cloud architecture and leadership; proficient in Go, Ruby, Rust, Python, JavaScript; 2+ years technical leadership; experience with distributed systems and cloud-based architectures.

Go, Ruby, Rust, Python, JavaScript, C, C++, C#, Java

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Staff Software Engineer

United States

$194k-$216k/yr RemoteFull Time

Honor Technology: Provides technology and professional care services for in-home senior care.

Backend engineering, API design, distributed systems, Python or willingness to learn Python, AWS, databases, and frontend basics.

Python, AWS, React, Next.js, TypeScript, Tailwind, APIs, Distributed systems

1mo

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1mo

Staff Software Engineer - Platform

United States

$180k-$240k/yr RemoteFull Time

Panther: Provides a cloud-native platform for threat detection and response.

Backend-focused staff engineer with AWS, Terraform, Go/Python, CI/CD, distributed systems, and platform ownership.

Terraform, CloudFormation, Datadog, Sentry, AWS, Golang, Python, CI/CD, Infrastructure as Code

1mo

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1mo

Staff Software Engineer

New York City, New York, United States

$210k-$300k/yr HybridFull Time

Standard Bots: Builds AI-powered robotic arms for industrial and commercial automation.

8+ YOE8+ years of professional software engineering; experience leading large-scale, cross-team programs; strong system design and communication skills; core stack fluency (React, Typescript, Node.js, Python, C++, Kubernetes).

React, Typescript, Node.js, Python, C++, Kubernetes

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Staff Software Engineer

Cambridge or New York

$200k-$325k/yr HybridFull Time

Iterative Health: Develops AI-driven precision medicine for gastrointestinal clinical research.

10+ YOE10+ years software engineering; healthcare data systems; 2+ years in a high-growth startup; strong system integration; ML/AI tooling; data pipelines; backend with Python/SQL; production ML infrastructure.

Python, SQL, Cloud Infrastructure, EHR/EMR integrations, AI tooling

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Staff Software Engineer

Boston, Massachusetts, United States

$147k-$215k/yr HybridFull Time

SimpliSafe: Provides wireless home security systems and professional monitoring services.

8+ YOE8–10+ years in software development, system validation, or automated testing for distributed or embedded systems; strong software architecture and design; Python proficiency; proven leadership.

Python

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Senior Staff Software Engineer

San Francisco, California, United States

$257k-$302k/yr OnsiteFull Time

Checkr: AI-powered platform for background checks and identity verification.

15+ YOESenior Staff Software Engineer with 5+ years leadership, 15+ years software experience, architecture leadership, Ruby/Go/Python, cloud, microservices, data pipelines, and cross-functional collaboration.

Ruby, Go, Python, Cloud, Microservices, Data pipelines, Asynchronous messaging, Domain-driven design

1mo

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1mo

Staff Software Engineer

United States

RemoteFull Time

Playlist: Software and marketplace platform for the wellness industry.

10+ YOE10+ years of software engineering; experience leading cross-team architecture; production microservices; AWS and containerization; monitoring/logging; SQL relational modeling; multi-language backend (ASP.NET, Python, C#, Ruby); frontend collaboration (Next.js, React).

AWS, EKS, EC2, ElastiCache, SNS, SQS, New Relic, Kibana, SQL, Relational data modeling, .NET Core, ASP.NET, C#, Python, Next.js, React, Ruby

2mo

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2mo

Staff Software Engineer - Cloud Services

United States

RemoteFull Time

Agiloft: Provides no-code contract lifecycle management and process automation software.

10+ YOE10+ years in software engineering; 2+ years at staff level; strong Python and Java; AWS; Terraform/CloudFormation; CI/CD; observability; AI-assisted development.

Python, Java, Terraform, CloudFormation, AWS, CI/CD

3mo

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3mo

Staff Software Engineer, Distributed Systems

San Francisco, California, United States

$250k-$300k/yr HybridFull Time

Ambience Healthcare: AI platform for medical documentation and clinical coding.

7+ YOE7+ years software engineering; 3+ years infra/backend; staff-level scope; strong Python/Go/TypeScript; Postgres; SF in-person 3x/week.

Python, Go, TypeScript, PostgreSQL

1mo

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1mo

Staff Software Engineer

Santa Clara, California, United States

$166k-$212k/yr OnsiteFull Time

AmbarellaNASDAQ: AMBA: Designs semiconductor chips for AI vision and video processing.

5+ YOEMaster’s degree in CS/EE; 5–10 years in systems/embedded software; strong C and Python; computer architecture knowledge; experience with software processes; problem-solving and communication skills.

C, Python, Embedded Systems, RTOS

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Staff Software Engineer

Berkeley, California, United States

$190k-$228k/yr OnsiteFull Time

Copper: Manufacturing battery-integrated induction stoves for simple home electrification.

10+ YOE10+ years of software development; cloud-based systems; TypeScript/Python; React; SQL; experience with AWS; strong collaboration and ownership.

TypeScript, Python, React, SQL, AWS, protobufs, RPC frameworks

2mo

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2mo

Staff Software Engineer

Hoboken, New Jersey, United States

$160k-$175k/yr OnsiteFull Time

PearsonLondon Stock Exchange: PSON: Provides digital learning content, assessments, and educational services globally.

10+ YOESenior-level software engineering with architecture leadership and AI/ML integration experience.

ReactJS, Java, Python, SQL, AWS, Azure, GCP, LLM, Agentic AI, Retrieval-Augmented Generation