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Staff Python Software Engineer Jobs in San Marcos, CA, US
33 staff python software engineer jobs from 15 companies hiring in San Marcos, CA, US.
1mo
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Staff Software Developer
Poway, California, United States
$128k-$229k/yr OnsiteFull Time
8+ YOESenior embedded software engineer with real-time systems, C/C++, Python; DoD Top Secret clearance; 8+ years of experience.
C/C++, Python, RTOS, CANbus, ARINC-429, MIL-STD-1553, SPI, I2C, USART, Ethernet, Git, SVN, Oscilloscopes, Logic Analysers, Power Supplies, Emulators
1w
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Staff Software Engineer, Software Systems
San Diego, California, United States
$144k-$175k/yr OnsiteFull Time
7+ YOE7+ years software engineering; robotics/embedded experience; C++ expert; Python; Linux; HAL/middleware; telemetry; AMRs familiarity.
C++11, C++, Python, Linux, CMake, Google Test, MQTT, Git
1mo
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Staff Software Developer
Poway, California, United States
$106k-$190k/yr OnsiteFull Time
8+ YOESenior-level software engineer with 8+ years, strong C++17, Linux, and embedded system experience.
C++ 17, Petalinux, Linux, Git, Python, Bash, SoC, Xilinx SDK, SPI/I2C/UART/Ethernet, Unit Testing Tools
2w
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Staff Software Engineer
San Diego, California, United States
$200k-$226k/yr HybridFull Time
10+ YOEBachelor's in CS/CE plus 10 years in software engineering; strong experience with distributed systems, cloud, and modern tech stack.
AWS, Kubernetes, Kafka, RabbitMQ, DynamoDB, SQL, NoSQL, .NET, ASP.NET Core, Angular, TypeScript, JavaScript, Python, REST, Microservices, CI/CD, Containerization, Infrastructure as Code, Monitoring/Observability
6d
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Staff Engineer Software Quality
San Diego, California, United States
$161k-$241k/yr OnsiteFull Time
Bachelor’s in engineering or related field; strong C++, Python; Agile; software quality and process experience.
C++, Python, IBM DOORS
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Staff Software Engineer, Enterprise Services
Palo Alto or Irvine or Atlanta
$173k-$258k/yr HybridFull Time
5+ YOEBachelor’s or Master’s in CS/Information Systems; 5+ years software engineering; strong system design, distributed architectures, async; backend in Java/Python/Go/C#; frontend (React/Next.js); cloud (AWS/Azure/GCP); Docker/K8s; Kafka/RabbitMQ; AI tooling; ITIL/ITSM familiarity; focus on automation and user experience.
Java, Python, Go, C#, React, Next.js, AWS, Azure, GCP, Docker, Kubernetes, Kafka, RabbitMQ, GitHub Copilot, Cursor, ITIL/ITSM
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Staff Software Engineer, Applied AI
Encinitas, California, United States
$178k-$201k/yr HybridFull Time
7+ YOE7+ years software engineering, 1+ year applied AI/ML in production; strong Python, APIs, data pipelines; experience with LLMs, prompt engineering, RAG, and CI/CD; Git/GitHub workflows.
Python, APIs, Data pipelines, Git, GitHub, CI/CD, LangChain, LangGraph, CrewAI, Sola, Glean, Claude, OpenAI, Anthropic, Gemini
2mo
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Staff Engineer, Software Systems (R4445)
San Diego or Dallas or Washington, D.C. or Boston
$140k-$210k/yr OnsiteAll Commitments Available
5+ YOE5+ years systems engineering or related experience; BS in STEM; MBSE experience; software experience in C++/Python; able to obtain US security clearance.
C++, Python, MBSE, SysML, UML, Cameo
3w
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Senior Staff Software Engineer, UI Lead
San Diego, California, United States
$169k-$296k/yr OnsiteFull Time
12+ YOE12+ years software engineering; frontend leadership; AI integration experience; strong JS/React; Java/Python backend; Kubernetes; REST.
JavaScript, React, Angular, Lit Framework, SASS, CSS-in-JS, Styled Components, Jest, Cypress, TestCafe, Mocha, Selenium, Java, Python, Spring, Hibernate, Kubernetes, REST, SQL
2w
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Staff Engineer - AI Platform
San Diego, California, United States
$169k-$254k/yr RemoteFull Time
8+ YOE8+ years in software architecture, AI infrastructure; experience with autonomous agents and LLMs; cloud-native systems; strong collaboration; BS/MS in CS/Engineering.
Python, Go, Java, LangChain, OpenAI, AutoGen, CrewAI
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Staff Bioinformatics Engineer
San Diego, California, United States
$129k-$163k/yr HybridFull Time
Senior-level bioinformatics platform engineer with Nextflow, AWS, Python, React, Linux/HPC, and data integration experience.
Nextflow, AWS, Slack, Jira, HubSpot, Snowflake, Python, React, Linux, HPC
1w
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Staff Full-Stack Software Engineer (HYBRID)
San Diego, California, United States
$113k-$188k/yr HybridFull Time
6+ YOE6+ years in full-stack development; BS in Computer Science, Engineering, IT, or related field; strong experience with modern Web UI frameworks and backend languages; cloud familiarity (GCP/AWS).
React, Angular, Vue.js, Node.js, Java, Python, MongoDB, PostgreSQL, HTML, CSS, TypeScript, Google Cloud Platform, Amazon Web Services
3w
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Staff AI Engineer, Payments
Roseville or Austin or Bentonville or Dallas or Irvine or Lehi or Plano or San Francisco or West Palm Beach
$17k-$20k/yr HybridFull Time
6+ YOE6+ years backend development with 2+ years AI/ML or LLMs; experience with MCP Servers, API design (REST/GraphQL/gRPC), cloud (AWS/GCP/Azure); vector DBs, MLOps, CI/CD; Node.js, Python, TypeScript.
Node.js, Python, TypeScript, REST, GraphQL, gRPC, Kafka, AWS, GCP, Azure, LangChain, Semantic Kernel, Haystack
1w
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Staff Site Reliability Engineer
San Diego, California, United States
$199k-$299k/yr HybridFull Time
7+ YOE7+ years AWS experience; 10+ years in production software environments; strong SRE with Java/C++; proficient in AWS services, monitoring, CI/CD, containers.
AWS, RDS, DynamoDB, ElastiCache, DataDog, CloudWatch, Splunk, Docker, Kubernetes, EKS, Fargate, CI/CD, API Gateway, ALB, R53, Java, C++, Python, Go
6d
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Sr Staff SoC Design Verification Manager
San Diego, California, United States
$172k-$254k/yr OnsiteFull Time
10+ YOE5+ Mgmt10+ years verification and firmware/software development; 5+ years leading a DV team; SystemVerilog/UVM; test planning; scripting (Python/Perl); C/C++; Linux; networking a plus.
SystemVerilog, UVM, Python, Perl, C++, ARM, Linux
HiringCafe market data
Staff Python Software Engineer Jobs market signals in San Marcos, CA, US
These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.
Open jobs
33
Hiring companies
15
Fresh sample
59% new in 30d
Salary visibility
100% show pay
Companies appearing in this market
Northrop GrummanShield AIBrain CorpGeneral AtomicsServiceNowGeneral Atomics Aeronautical SystemsTeradataFlock Freight
Work location mix in visible results
Onsite: 17Hybrid: 11Remote: 1