📣 HiringCafe is hiring a Founding Growth Hacker! Learn More · Apply here
Limited-index browse page
Lead Python Developer Jobs in Martinez, CA, US
470+ lead python developer jobs from 220+ companies hiring in Martinez, CA, US.
3w
Save
Mark Applied
Hide
Matterport - Technical Manager (Kotlin)
Sunnyvale, California, United States
$179k-$270k/yr HybridFull Time
8+ YOELeads software development teams; 8+ years cloud platform experience; Kotlin/Java/Go/Python; Linux/Databases; React.js; billing systems; full-stack capability.
Kotlin, Java, Go, Python, Linux, MySQL, PostgreSQL, Git, React.js, FoundationDB
1mo
Save
Mark Applied
Hide
Principal Scientist, Lyophilization Development
Fremont, California, United States
$180k-$200k/yr OnsiteFull Time
11+ YOELead lyophilization development, transfer to manufacturing, and mentor scientists.
Lyophilization equipment, DSC, Cryo-microscopy, JMP, Python, R, Automated liquid handling systems, High-throughput assays, Immunoassays, SOPs, Batch records, Product specifications, Validation reports, Technology transfer packages
4w
Save
Mark Applied
Hide
Associate Director, Computational Development
Remote or South San Francisco
$192k-$208k/yr HybridFull Time
8+ YOE5+ MgmtPhD in a quantitative field; 8+ years total experience with 5+ years in biotech/regulated healthcare; leading NGS/ctDNA MRD assay development; strong Python; design-controlled environments (CAP/CLIA LDT/IVD); team leadership.
Python, AWS, R, SQL, Docker, S3, Lambda, Step Functions
2mo
Save
Mark Applied
Hide
👨💻 Head of Engineering👨💻
Walnut Creek, California, United States
$130k-$200k/yr OnsiteFull Time
Lead engineering team; strong JS, Python, cloud, Docker, AWS; experience in materials/chemistry data science.
JavaScript, Python, Linux, Cloud (AWS, Azure, GCP), Docker, Vagrant, MongoDB, React, MeteorJS
4w
Save
Mark Applied
Hide
Senior Manager, Software Engineering
San Francisco, California, United States
$232k-$290k/yr HybridFull Time
12+ YOE3+ MgmtLead software engineers; 12+ years exp; 3+ years leadership; distributed systems; Go/Java/Python; Kubernetes; AWS.
Go, Java, Python, Kubernetes, AWS
3mo
Save
Mark Applied
Hide
Research Engineering Manager - Model Training
San Francisco, California, United States
$300k-$470k/yr OnsiteFull Time
8+ YOE2+ MgmtLead or oversee AI research/engineering teams; strong Python/PyTorch skills; experience with large-scale AI models; 10+ years total experience with at least 2 years in management; production model development focus.
Python, PyTorch, Machine Learning Frameworks
2w
Save
Mark Applied
Hide
Sr. Manager, AI/ML & Software Development
Austin or Newark
HybridFull Time
8+ YOE3+ MgmtBachelor's degree in Computer Science or Engineering; 8+ years software/AI experience; 3+ years leading engineering teams; strong Python, PyTorch, and ML experience; Agile, KPI-driven; cloud and on-prem deployment experience.
Python, PyTorch, Hugging Face, CI/CD, Cloud, ML platforms
1mo
Save
Mark Applied
Hide
Principal Scientist, Oncology Bioinformatics
Foster City, California, United States
$196k-$253k/yr HybridFull Time
6+ YOELead multi-omics analysis, develop statistical models, and communicate findings to teams.
R, Python, Perl, Java, C/C++, HPC, Cloud Computing
6d
Save
Mark Applied
Hide
Sr. Net Architect
Berkeley, California, United States
OnsiteFull Time
7+ YOELead design/development of .NET 8 ASP.NET Core apps; expert in SQL Server; frontend in React/Angular; healthcare/LIS domain experience preferred.
C#, REST, Microsoft SQL Server, T-SQL, Stored procedures, Query optimization, Indexing strategies, Performance tuning, Database schema design, ASP.NET Core, React, Angular, Git, CI/CD, Python, Sitecore, Tableau, Power BI
2w
Save
Mark Applied
Hide
Member of Technical Staff - Pretraining
Freiburg or San Francisco
HybridFull Time
Lead or co-own pretraining of foundation models; large-scale distributed training; Python and PyTorch; architecture/ objective design.
Python, PyTorch, Distributed training, FSDP, TP, PP, GPU
5d
Save
Mark Applied
Hide
Principal Research Scientist - AI Scaling & Optimization
San Francisco or Mountain View
$270k-$350k/yr OnsiteFull Time
Lead a research team focused on foundation model efficiency, scalable ML systems, and optimization; strong Python and PyTorch programming; proven research impact.
Python, PyTorch
1mo
Save
Mark Applied
Hide
Software Engineering - ODSP
Santa Clara or Westlake Village
$155k-$232k/yr OnsiteFull Time
10+ YOE2+ Mgmt10+ years embedded C/C++ firmware development; SW Team Lead experience; architecture and testing leadership; DSP/embedded SoC knowledge; strong English communication; experience with revision control and defect tracking.
C, C++, Python, Git, Linux, Makefiles, GDB, IDEs, bash, Verilog
1mo
Save
Mark Applied
Hide
Postdoctoral Researcher, Real-Time Generative AI for Automotive XR
Los Altos, California, United States
$152k-$219k/yr OnsiteFull Time, Temporary
PhD in ML/CS/EE or related field; strong ML/CV background; publications; Python; Linux; XR/real-time AI experience; ability to lead research.
Python, Linux, GPUs, Image/Video Generative Models
4w
Save
Mark Applied
Hide
Product Scientist (Computational Chemist)
New York City or San Francisco or Boston
$180k-$220k/yr HybridFull Time
5+ YOE5+ years on project teams; broad technical range across cheminformatics, modeling, ML, and DMPK; strong Python skills; ability to lead cross-functional discussions and communicate complex analyses.
Python, Claude Code
3w
Save
Mark Applied
Hide
Senior Scientist
Emeryville, California, United States
$164k-$182k/yr OnsiteFull Time
3+ YOELead bioanalytical assay development for immunogenicity, PK/PD, and biomarkers in gene-therapy programs; regulatory-compliant, data-driven analyses; mentorship and cross-functional collaboration.
PCR, qPCR, ddPCR, RNA-seq, LC-MS, Meso Scale Discovery, SoftMax, Python, R, JMP, GraphPad Prism, Excel
1mo
Save
Mark Applied
Hide
Head of AI Products
New York City or San Mateo
$230k-$270k/yr HybridFull Time
8+ YOELead AI product development for investment platforms; 8–15 years in AI/ML and finance; strong CS, ML, portfolio knowledge; Python/C++.
Python, C++, Machine Learning
2mo
Save
Mark Applied
Hide
Scaling Experiments for AI-designed Medicines
Palo Alto, California, United States
$245k-$305k/yr OnsiteFull Time
12+ YOE5+ MgmtPhD with 12+ years in industrial drug development; leads a data-driven lab of 10+ scientists; strong lab strategy and operational execution; expertise in molecular/cellular biology and high-throughput assays; global collaboration.
Python, High-throughput assays, Multiplexed assays, Laboratory automation
3mo
Save
Mark Applied
Hide
Senior Engineering Manager
Menlo Park or Austin or Raleigh or Nashville or Toronto
$185k-$272k/yr HybridFull Time
Lead multiple distributed software teams; drive design, delivery, and high-scale engineering programs.
Python, Typescript, React, APIs
2mo
Save
Mark Applied
Hide
Director of Software Engineering, NX Designer
Fremont, California, United States
$240k-$260k/yr OnsiteFull Time
10+ YOE3+ Mgmt10+ years leading cloud software teams; strong cloud architecture, microservices, AI/ML integration; leadership of multinational teams.
Python, Node.js, Java, Cloud platforms, Microservices, CI/CD, DevOps, APIs, Serverless
1mo
Save
Mark Applied
Hide
Senior Manager/Associate Director, Software, Platform Engineering
Menlo Park, California, United States
$196k-$294k/yr HybridFull Time
5+ YOE3+ MgmtLead platform engineering; deploy software on hardware; build CI/CD for instruments; 5+ years hardware software deployment; leadership.
Linux, Docker, Podman, Singularity, CI/CD, Python, C++, C#, Ansible, Puppet, Chef
5d
Save
Mark Applied
Hide
Sr. Director, Applications Engineering
San Francisco, California, United States
$284k-$423k/yr HybridMultiple Commitments Available
15+ YOE15+ Mgmt15+ years leading global engineering teams; BA/BS in Computer Science or related field; strong leadership, coaching, and architectural skills.
JavaScript, TypeScript, React, Angular, Node.js, Java, Python, AWS, Azure, GCP, Microservices, CI/CD, SRE, AI/ML, LangGraph, CrewAI
1mo
Save
Mark Applied
Hide
Engineering Manager, RCM Core Platform
Mountain View, California, United States
$200k-$225k/yr OnsiteFull Time
6+ YOE3+ Mgmt6+ years software development; 3+ years leading engineering teams; strong communication; healthcare impact; experience managing 10+ engineers; backend focus Python, PostgreSQL, Kubernetes; leadership in architecture decisions.
Python, PostgreSQL, Kubernetes
1mo
Save
Mark Applied
Hide
Director, Data Platform Engineering
San Francisco, California, United States
$232k-$304k/yr OnsiteFull Time
12+ YOE5+ Mgmt12+ years software development in data processing at scale; 5+ years leading senior engineers; experience with AWS/GCP primitives; petabyte-scale data platforms; Python; Kubernetes; IaC; containerized deployments.
Python, Kubernetes, Kafka, Flink, DuckDB, ClickHouse, S3, BigQuery, Terraform, Airflow
1mo
Save
Mark Applied
Hide
Software Engineering Manager 1 – Streaming & Cloud Platform Reliability
Cupertino, California, United States
$156k-$315k/yr HybridFull Time
7+ YOE2+ Mgmt7+ years software engineering; 2+ years team lead; 3+ years distributed streaming systems; strong backend/API, cloud, incident response.
Kafka, Flink, Storm, Python, Go, Java, Kubernetes, Docker, Redis, PostgreSQL, Cassandra, S3, GCS, REST, WebSocket, Webhooks
3w
Save
Mark Applied
Hide
Senior Manager, Statistical Programming - Job ID: 1646
Palo Alto, California, United States
$170k-$180k/yr HybridFull Time
10+ YOE2+ MgmtBachelor’s or Master’s in a related field; 10+ years (Bachelor) or 7+ years (Master) of programming in pharma; lead programmer; CDISC SDTM/ADaM; SAS; R/Python a plus; develop reusable macros; strong communication.
SAS, CDISC SDTM, CDISC ADaM, R, Python, Git, VB, Macro development
1mo
Save
Mark Applied
Hide
Engineering Manager
San Francisco or New York City
$220k-$250k/yr HybridFull Time
3+ YOE2+ Mgmt2+ years of people management; 3+ years as a full-stack engineer; strong web APIs, frontend, and DB skills; effective communication; ability to lead complex technical projects.
Python, Typescript, PostgreSQL, Airflow, AWS, Google Cloud Platform, Flask, React, Apollo GraphQL
2w
Save
Mark Applied
Hide
Director of Engineering - AI
Mountain View, California, United States
$250k-$300k/yr OnsiteFull Time
8+ YOE2+ Mgmt8-10 years backend software engineering, 2+ years leading AI/ML teams; hands-on model training; deploy agentic AI apps; scalable ML infra; strong leadership and communication.
PyTorch, TensorFlow, Hugging Face, LangChain, Ray, Python, Java, Scala, C++
2mo
Save
Mark Applied
Hide
Senior Solutions Architect
San Francisco, California, United States
$155k-$175k/yr HybridFull Time
6+ YOE6–10+ years in technical customer-facing roles; strong experience leading complex, multi-stakeholder projects; proficient with APIs and integrations; AI/LLM interest; ability to influence roadmaps; global collaboration.
Python, JavaScript, Node.js, REST APIs, AWS Lambda
2w
Save
Mark Applied
Hide
Senior Nuclear Enterprise Systems Analyst
Livermore, California, United States
$176k-$267k/yr HybridFull Time
DOE Q clearance; Bachelor's in operations research, engineering, physics, applied math, CS, economics, or related field; experience leading multidisciplinary teams; software development in Python/SQL/TypeScript/Go/C++; strong analytical and communication skills; ability to travel.
Python, SQL, TypeScript, Go, C++, Windows, Linux
2mo
Save
Mark Applied
Hide
Engineering Manager, Machine Learning Behavior Planning & Prediction
Palo Alto, California, United States
$140k-$230k/yr HybridFull Time
3+ YOE3+ MgmtLead an engineering team to develop ML models for planning and prediction in AD/ADAS; focus on data pipelines and vehicle deployment; strong ML expertise; 3+ years managing teams; 5+ years ML workflows; Python proficiency; self-driving product experience.
Python
1mo
Save
Mark Applied
Hide
Director, Health Economics & Outcomes Research (HEOR)
San Carlos, California, United States
$242k-$282k/yr HybridFull Time
8+ YOEPhD or Master’s with extensive experience in health economic modeling, leading cost-effectiveness and budget impact analyses, and cross-functional leadership.
R, Python, SAS, Health Economic Modeling, Decision-analytic modeling, Markov models, Microsimulation, Dynamic transmission models
1w
Save
Mark Applied
Hide
Associate Director of Biostatistics
San Carlos, California, United States
$192k-$240k/yr RemoteFull Time
7+ YOELead a team of biostatisticians; 7+ years in clinical trial biostatistics; advanced degree in biostatistics; expertise in survival analysis and study design; mentoring.
SAS, R, Python, SQL, Power BI
1mo
Save
Mark Applied
Hide
Senior Manager, Analytical AI Clinical Development
Princeton or Seattle or Brisbane
$152k-$184k/yr OnsiteFull Time
3+ YOELead design and deployment of ML pipelines for clinical development; collaborate with cross-functional teams; manage AI product lifecycle; stay updated on AI trends.
Python, SQL, TensorFlow, PyTorch, scikit-learn, Airflow, Dagster, AWS, Azure, Git, GitHub, MLOps, NLP, LLMs, Real-World Data, Streamlit, Dash, Shiny, Bioinformatics
1mo
Save
Mark Applied
Hide
Head of Bio AI - Radial
Emeryville, California, United States
$400k-$600k/yr OnsiteFull Time
Lead AI and computational architecture; build scalable ML pipelines; manage a small team; hybrid role in Emeryville, CA; nonprofit; visa sponsorship possible.
Machine Learning, Distributed Computing, Diffusion Models, Transformers, Python, Data Pipelines
2mo
Save
Mark Applied
Hide
Postdoctoral Fellow, Kelley Lab - Gene Regulation Machine Learning
South San Francisco, California, United States
$95k/yr OnsiteFull Time
PhD in a relevant scientific or computational field; strong research record; onsite 5 days/week; excellent communication; able to lead and collaborate; proficient in data analysis.
Python, R, Machine Learning, Genomics
1mo
Save
Mark Applied
Hide
AI in Residence
South San Francisco or Seattle or London
$10k-$15k/mo HybridInternship, Full Time
Recent MS or PhD in ML/AI or related fields; strong publications or artifacts; ability to lead technical work; interest in translating research to deployable AI for therapeutics.
Python, PyTorch, TensorFlow, scikit-learn, Jupyter
2w
Save
Mark Applied
Hide
Principal Scientist, Computational Chemistry
South San Francisco, California, United States
$203k-$236k/yr OnsiteFull Time
12+ YOEPhD in Computational Chemistry or related field; 12+ years biotech/pharma experience; hands-on computational chemistry, modeling, and lead discovery; strong collaboration and communication; medicinal chemistry and DMPK knowledge.
MOE, Schrodinger, cloud computing, FEP, AlphaFold2, Python, R
1mo
Save
Mark Applied
Hide
Engineering Manager, Data Compute Platform
San Francisco, California, United States
$199k-$275k/yr HybridFull Time
8+ YOE3+ Mgmt8+ years in high-scale software development; 3+ years leading engineering teams; experience with data storage, data lakes/lakehouses, data warehouses; cloud data ecosystems; Spark, Flink, Kafka, Airflow, Kubernetes; Python/Java/Scala; SQL; Snowflake, Iceberg; RBAC and PII/security practices; AI-ready data foundations.
Spark, Flink, Kafka, Airflow, Kubernetes, Python, Java, Scala, SQL, Snowflake, Iceberg, AWS, GCP, Azure
1w
Save
Mark Applied
Hide
Manager, Systems Test Engineering
Brisbane, California, United States
$170k-$190k/yr OnsiteFull Time
Lead a team of systems test engineers; develop validation methods; collaborate across engineering functions; ensure equipment meets specs.
Python, C++
1mo
Save
Mark Applied
Hide
Associate Director of Analytics and Evaluation (32675)
San Francisco, California, United States
$130k-$145k/yr HybridFull Time
5+ YOE2+ MgmtLead analytics, data engineering, and team management; develop dashboards and data products; 5+ years experience; Bachelor's in quantitative field.
SQL, Python, Cloud_data_platforms, Tableau, Power BI, Git/GitHub, Azure DevOps
HiringCafe market data
Lead Python Developer Jobs market signals in Martinez, CA, US
These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.
Open jobs
470+
Hiring companies
220+
Fresh sample
41% new in 30d
Salary visibility
93% show pay
Companies appearing in this market
Databricks4D Molecular TherapeuticsAlamar BiosciencesAsanaAscendis PharmaAstera InstituteBlack Forest LabsBristol Myers Squibb
Work location mix in visible results
Hybrid: 21Onsite: 19Remote: 1