📣 HiringCafe is hiring a Founding Growth Hacker! Learn More · Apply here
Limited-index browse page
Lead Python Developer Jobs in Vacaville, CA, US
170+ lead python developer jobs from 110+ companies hiring in Vacaville, CA, US.
1mo
Save
Mark Applied
Hide
Lead AI Research Scientist
Los Angeles or Irvine or San Francisco
$227k-$363k/yr OnsiteFull Time
6+ YOEMS/PhD in CS/AI/ML; 6+ years (post-MS) or 4+ years (post-PhD) in advanced AI; strong in generative AI, LLMs, agentic systems, knowledge graphs, RL, Transformers; ability to lead research from concept to production.
Python, TensorFlow, PyTorch, Transformers, Knowledge Graphs
2mo
Save
Mark Applied
Hide
Founding Robotic Engineer - FTE
San Francisco, California, United States
$150k-$250k/yr HybridFull Time
Lead founding robotics engineer role building real-robot systems, including teleoperation, data pipelines, and ML infrastructure; requires hands-on robotics, ROS/ROS2, Python/C++, and hardware experience.
ROS/ROS2, Python, C++, Real-time systems, Networking
2w
Save
Mark Applied
Hide
Senior Controls Engineer
Livermore, California, United States
$200k-$260k/yr OnsiteFull Time
10+ YOELead design and implementation of control systems for high-energy laser platforms; 10+ years in controls; PLC, embedded and real-time software; C/C++, Python; motion control; system integration.
PLC programming, Embedded systems, Real-time software, C/C++, Python, MATLAB/Simulink
1w
Save
Mark Applied
Hide
Workplace Research Lead
Chicago or Los Angeles or Arlington or San Francisco or Seattle or Boston or San Jose
OnsiteFull Time
3+ YOEPhD preferred or Master’s in I/O psychology/related field; 3+ years applied research in industry; experience with mixed methods, client-facing work, and AI tools.
Power BI, Python, R
2w
Save
Mark Applied
Hide
Staff Electrical Engineer
San Francisco, California, United States
$154k-$230k/yr OnsiteFull Time
12+ YOELead hardware development for LIDAR, drive electrical system architecture, and execute from concept to production; 12+ years analog/digital design; embedded SoC; PCB/HDI expertise.
Altium, HDI PCB, Schematic capture, Ethernet, CAN, I2C, SPI, USB, Python, FPGA, ARM, DSP, HDI multi-layer PCB
2mo
Save
Mark Applied
Hide
Principal Site Reliability Engineer (SRE)
Dallas or San Francisco or Austin
$180k-$210k/yr RemoteFull Time
12+ YOE5+ Mgmt12+ years SRE/Infrastructure, 5+ years leading SRE teams, strong Python/Go/Java, GCP expertise, Docker/Kubernetes, monitoring, AI/ML for SRE, incident management, budgeting and capacity planning, distributed systems knowledge
Python, Go, Java, Prometheus, Grafana, Datadog, New Relic, Docker, Kubernetes, Cloud Monitoring, Cloud Logging, Cloud Trace, GKE, Compute Engine, Cloud Functions
2mo
Save
Mark Applied
Hide
R&D Test Engineer
Alameda, California, United States
$128k-$162k/yr OnsiteFull Time
4+ YOEExperience leading experimental R&D projects; strong lab testing, data analysis in Python; knowledge of mechanical, thermal systems; BS in engineering or physical sciences; 4+ years experience; ability to operate lab instruments and electronics.
Python, Laboratory instrumentation, Electronics, Data analysis software
4d
Save
Mark Applied
Hide
Chief GenAI Engineer
Sacramento or Oakland
HybridFull Time
Lead design and delivery of AI solutions; hands-on engineering with cloud platforms; mentor and ensure responsible AI.
Python, Cloud platforms, MLOps, RAG, Snowflake
2mo
Save
Mark Applied
Hide
Principal AI Safety Engineer for Autonomous Vehicles: Technical Lead (GPSSC)
San Francisco, California, United States
$251k-$385k/yr RemoteFull Time
10+ YOEBachelor in CS/EE/Math/Physics or related; 10+ years AI/ML experience; 5+ years in autonomous vehicles/ robotics; strong AI safety, data lifecycle, and deployment expertise.
Python, R, Java, PySpark, PyTorch, TensorFlow, Scikit-learn, LangChain, SQL
4w
Save
Mark Applied
Hide
Senior Field Engineer
Berkeley, California, United States
$120k-$140k/yr OnsiteFull Time
3+ YOE3+ Mgmt3+ years in field engineering or technical operations; experience leading distributed teams; travel up to 50%; hardware and software product support.
Jira Service Management, Grafana, Python, Linux, Command Line Interface
2d
Save
Mark Applied
Hide
Principal Data Engineer
San Francisco, California, United States
$207k-$276k/yr HybridFull Time
15+ YOE15+ years in software, FinTech, leading cross-functional teams; expert in data engineering, SDLC, cloud, and architectures; hands-on with Java, microservices, big data, and CI/CD.
Java, Spring, Microservices, Kafka, Oracle, SQL, JavaScript, Python, Hadoop/S3, Spark, TensorFlow, PyTorch, CI/CD, Git, Jenkins, Terraform, AWS, GCP, Azure, Jira, Confluence
2mo
Save
Mark Applied
Hide
Compliance Technology Oversight Lead
Oakland, California, United States
$218k-$327k/yr RemoteFull Time
10+ YOE10+ years in compliance technology for regulated financial institutions or FI consulting; ML and heuristic model experience; data monitoring and model performance oversight; regulatory exam responses; agile development.
Machine Learning, Data Visualization, Agile, Python, Model Monitoring
1mo
Save
Mark Applied
Hide
Forward Deployed Engineer
San Francisco or New York City
HybridFull Time
Lead discovery with customer engineers; design and build Cursor-powered workflows; ship production-ready systems; own production quality and communicate tradeoffs; collaborate with leadership; turn builds into reusable Cursor patterns.
Python, TypeScript, JavaScript
2mo
Save
Mark Applied
Hide
Client Engineer III (MedInsight)
Seattle or Appleton or Atlanta or Boise or Wakefield or Chicago or Dallas or Hartford or Omaha or San Francisco or Portland or Portland
$85k-$162k/yr RemoteFull Time
5+ YOE5+ years in analytics/data engineering with client-facing delivery; expert SQL; dimensional modeling; strong software engineering practices; able to lead data-driven implementations.
SQL, Git, CI/CD, ETL, Data Modeling, Python, Cloud
6d
Save
Mark Applied
Hide
Knowledge Engineer / Semantic Expert for AI
Mountain View or Milwaukee or Dallas or Columbus or Kirkland or Cincinnati or New York or Cleveland or Oklahoma City or Austin or Albany or Chicago or St. Petersburg or Hartford or Pittsburgh or St. Louis or Miami or Sacramento or Raleigh or Minneapolis or Scottsdale or San Francisco or Morristown or Denver or Boston or Philadelphia or Des Moines or Overland Park or Los Angeles or Charlotte or Walnut Creek or Carmel or Seattle or Houston or Arlington or Atlanta or Redmond or Bentonville or Beaverton or Nashville or Detroit or San Diego
HybridFull Time
12+ YOELead Knowledge Graph and AI solutions; design ontologies; build end-to-end data pipelines; team leadership; strong RDF/graph DB expertise.
RDF, SPARQL, LPG, SHACL, Neo4J, Stardog, Amazon Neptune, Python, TensorFlow, PyTorch, Airflow, NiFi, LLMs
1mo
Save
Mark Applied
Hide
Principal Software Engineer, B2B Engineering
San Francisco, California, United States
$385k-$490k/yr OnsiteFull Time
Design and scale backend services; lead architecture of distributed systems, databases, data pipelines; ensure security, reliability, and API quality; strong collaboration across teams.
Python, Go, Rust, TypeScript
6d
Save
Mark Applied
Hide
Engineering Manager, Internal Platform
San Francisco or New York
$240k-$260k/yr HybridFull Time
Leading and growing a platform engineering team; strong Go/Python, Kubernetes, CI/CD; monorepos; developer tooling; cross-functional leadership.
Go, Python, Kubernetes, Docker, Helm, Monorepo tooling, CI/CD
2w
Save
Mark Applied
Hide
Software Integration & Test Engineer (Midlevel or Senior)
Beale AFB, California, United States
$112k-$152k/yr OnsiteFull Time
3+ YOEBachelor’s Degree; Active Top Secret US Security clearance; 3+ years in software system integration and test; 3+ years in DevSecOps; 3+ years as a Systems Engineer leading integration and test.
Python, Bash, Matlab, Docker, Kubernetes, Jira, Confluence, Git, DOORS, MSOSA/Cameo
2mo
Save
Mark Applied
Hide
👨💻 Head of Engineering👨💻
Walnut Creek, California, United States
$130k-$200k/yr OnsiteFull Time
Lead engineering team; strong JS, Python, cloud, Docker, AWS; experience in materials/chemistry data science.
JavaScript, Python, Linux, Cloud (AWS, Azure, GCP), Docker, Vagrant, MongoDB, React, MeteorJS
4w
Save
Mark Applied
Hide
Senior Manager, Software Engineering
San Francisco, California, United States
$232k-$290k/yr HybridFull Time
12+ YOE3+ MgmtLead software engineers; 12+ years exp; 3+ years leadership; distributed systems; Go/Java/Python; Kubernetes; AWS.
Go, Java, Python, Kubernetes, AWS
3mo
Save
Mark Applied
Hide
Research Engineering Manager - Model Training
San Francisco, California, United States
$300k-$470k/yr OnsiteFull Time
8+ YOE2+ MgmtLead or oversee AI research/engineering teams; strong Python/PyTorch skills; experience with large-scale AI models; 10+ years total experience with at least 2 years in management; production model development focus.
Python, PyTorch, Machine Learning Frameworks
6d
Save
Mark Applied
Hide
Sr. Net Architect
Berkeley, California, United States
OnsiteFull Time
7+ YOELead design/development of .NET 8 ASP.NET Core apps; expert in SQL Server; frontend in React/Angular; healthcare/LIS domain experience preferred.
C#, REST, Microsoft SQL Server, T-SQL, Stored procedures, Query optimization, Indexing strategies, Performance tuning, Database schema design, ASP.NET Core, React, Angular, Git, CI/CD, Python, Sitecore, Tableau, Power BI
2w
Save
Mark Applied
Hide
Member of Technical Staff - Pretraining
Freiburg or San Francisco
HybridFull Time
Lead or co-own pretraining of foundation models; large-scale distributed training; Python and PyTorch; architecture/ objective design.
Python, PyTorch, Distributed training, FSDP, TP, PP, GPU
4d
Save
Mark Applied
Hide
Principal Research Scientist - AI Scaling & Optimization
San Francisco or Mountain View
$270k-$350k/yr OnsiteFull Time
Lead a research team focused on foundation model efficiency, scalable ML systems, and optimization; strong Python and PyTorch programming; proven research impact.
Python, PyTorch
4w
Save
Mark Applied
Hide
Product Scientist (Computational Chemist)
New York City or San Francisco or Boston
$180k-$220k/yr HybridFull Time
5+ YOE5+ years on project teams; broad technical range across cheminformatics, modeling, ML, and DMPK; strong Python skills; ability to lead cross-functional discussions and communicate complex analyses.
Python, Claude Code
3w
Save
Mark Applied
Hide
Senior Scientist
Emeryville, California, United States
$164k-$182k/yr OnsiteFull Time
3+ YOELead bioanalytical assay development for immunogenicity, PK/PD, and biomarkers in gene-therapy programs; regulatory-compliant, data-driven analyses; mentorship and cross-functional collaboration.
PCR, qPCR, ddPCR, RNA-seq, LC-MS, Meso Scale Discovery, SoftMax, Python, R, JMP, GraphPad Prism, Excel
5d
Save
Mark Applied
Hide
Sr. Director, Applications Engineering
San Francisco, California, United States
$284k-$423k/yr HybridMultiple Commitments Available
15+ YOE15+ Mgmt15+ years leading global engineering teams; BA/BS in Computer Science or related field; strong leadership, coaching, and architectural skills.
JavaScript, TypeScript, React, Angular, Node.js, Java, Python, AWS, Azure, GCP, Microservices, CI/CD, SRE, AI/ML, LangGraph, CrewAI
1mo
Save
Mark Applied
Hide
Director, Data Platform Engineering
San Francisco, California, United States
$232k-$304k/yr OnsiteFull Time
12+ YOE5+ Mgmt12+ years software development in data processing at scale; 5+ years leading senior engineers; experience with AWS/GCP primitives; petabyte-scale data platforms; Python; Kubernetes; IaC; containerized deployments.
Python, Kubernetes, Kafka, Flink, DuckDB, ClickHouse, S3, BigQuery, Terraform, Airflow
1mo
Save
Mark Applied
Hide
Engineering Manager
San Francisco or New York City
$220k-$250k/yr HybridFull Time
3+ YOE2+ Mgmt2+ years of people management; 3+ years as a full-stack engineer; strong web APIs, frontend, and DB skills; effective communication; ability to lead complex technical projects.
Python, Typescript, PostgreSQL, Airflow, AWS, Google Cloud Platform, Flask, React, Apollo GraphQL
2mo
Save
Mark Applied
Hide
Senior Solutions Architect
San Francisco, California, United States
$155k-$175k/yr HybridFull Time
6+ YOE6–10+ years in technical customer-facing roles; strong experience leading complex, multi-stakeholder projects; proficient with APIs and integrations; AI/LLM interest; ability to influence roadmaps; global collaboration.
Python, JavaScript, Node.js, REST APIs, AWS Lambda
2w
Save
Mark Applied
Hide
Senior Nuclear Enterprise Systems Analyst
Livermore, California, United States
$176k-$267k/yr HybridFull Time
DOE Q clearance; Bachelor's in operations research, engineering, physics, applied math, CS, economics, or related field; experience leading multidisciplinary teams; software development in Python/SQL/TypeScript/Go/C++; strong analytical and communication skills; ability to travel.
Python, SQL, TypeScript, Go, C++, Windows, Linux
1mo
Save
Mark Applied
Hide
Head of Bio AI - Radial
Emeryville, California, United States
$400k-$600k/yr OnsiteFull Time
Lead AI and computational architecture; build scalable ML pipelines; manage a small team; hybrid role in Emeryville, CA; nonprofit; visa sponsorship possible.
Machine Learning, Distributed Computing, Diffusion Models, Transformers, Python, Data Pipelines
1mo
Save
Mark Applied
Hide
Engineering Manager, Data Compute Platform
San Francisco, California, United States
$199k-$275k/yr HybridFull Time
8+ YOE3+ Mgmt8+ years in high-scale software development; 3+ years leading engineering teams; experience with data storage, data lakes/lakehouses, data warehouses; cloud data ecosystems; Spark, Flink, Kafka, Airflow, Kubernetes; Python/Java/Scala; SQL; Snowflake, Iceberg; RBAC and PII/security practices; AI-ready data foundations.
Spark, Flink, Kafka, Airflow, Kubernetes, Python, Java, Scala, SQL, Snowflake, Iceberg, AWS, GCP, Azure
2mo
Save
Mark Applied
Hide
Senior Software Development Manager, Engage
San Francisco or Los Angeles or Irvine or Seattle or New York
$185k-$288k/yr OnsiteFull Time
3+ YOE3+ MgmtLead one of three engineering teams; 3+ years as software engineering manager; 5+ years in software engineering; proficiency in Go, Python, Java, or C/C++; design scalable systems; deliver customer-centric solutions; mentor team growth
Golang, Python, Java, C/C++, AWS
1w
Save
Mark Applied
Hide
Manager, Systems Test Engineering
Brisbane, California, United States
$170k-$190k/yr OnsiteFull Time
Lead a team of systems test engineers; develop validation methods; collaborate across engineering functions; ensure equipment meets specs.
Python, C++
1mo
Save
Mark Applied
Hide
Associate Director of Analytics and Evaluation (32675)
San Francisco, California, United States
$130k-$145k/yr HybridFull Time
5+ YOE2+ MgmtLead analytics, data engineering, and team management; develop dashboards and data products; 5+ years experience; Bachelor's in quantitative field.
SQL, Python, Cloud_data_platforms, Tableau, Power BI, Git/GitHub, Azure DevOps
1mo
Save
Mark Applied
Hide
Manager, Software Engineering - AI Product
San Francisco or New York
$258k-$376k/yr HybridFull Time
3+ YOE3+ Mgmt3+ years leading engineering teams; proven AI product development; 0→1 innovation; strong leadership and collaboration; interest in generative AI.
Python, PyTorch, TensorFlow
1w
Save
Mark Applied
Hide
Head of Deployment Strategy
San Francisco or New York City
$200k-$250k/yr OnsiteFull Time
8+ YOE3+ Mgmt8+ years in deployment strategy/forward deployment with 3+ years leading a team; proven ability managing complex customer relationships; familiar with AI model development lifecycle; strong communication with senior stakeholders; proven project management; ability to lead cross-functional collaboration.
SQL, Python
HiringCafe market data
Lead Python Developer Jobs market signals in Vacaville, CA, US
These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.
Open jobs
170+
Hiring companies
110+
Fresh sample
49% new in 30d
Salary visibility
85% show pay
Companies appearing in this market
DatabricksEarly Warning ServicesOpenAI4D Molecular TherapeuticsAccentureAmbi RoboticsAsanaAstera Institute
Work location mix in visible results
Onsite: 19Hybrid: 18Remote: 4