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Python Developer Jobs in Lancaster, MA, US
2,100+ python developer jobs from 540+ companies hiring in Lancaster, MA, US.
2w
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Senior Security Engineer, Detection and Response
Austin or San Francisco or Seattle or Boston or Washington
$182k-$202k/yr RemoteFull Time
5+ YOE5+ years in detection and response or security engineering; strong software fundamentals; experience with cloud (AWS); experience with log analysis and endpoint detection tools.
Python, Go, Ruby, CloudTrail, GuardDuty, VPC flow logs, Datadog, Splunk, ELK, SentinelOne, CrowdStrike
1mo
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Embedded Software Engineering Co-op
Lawrence, Massachusetts, United States
OnsiteFull Time, Internship
0+ YOEPursuing BS in Computer, Electrical, or Software Engineering; experience in C/C++, Python; embedded software development; ability to read schematics; familiarity with software development processes.
C/C++, Python, Embedded systems, Linux, Windows, Git, Debugging
2mo
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Sr. Solutions Engineer (Field) – US Remote, Boston
Boston, Massachusetts, United States
$150k-$250k/yr RemoteFull Time
5+ YOESenior Solutions Engineer with 5+ years in technical pre-sales or solutions engineering; strong cloud and cybersecurity knowledge; excellent communication and demo skills.
AWS, Azure, GCP, Python, Bash, PowerShell, APIs, Scripting
5h
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Integrated Photonics Design Engineer, Device Components
Cambridge, Massachusetts, United States
$120k-$225k/yr OnsiteFull Time
5+ YOE5+ years experience or advanced degree in Electrical Engineering, Physics, or related field; photonic device design; FEM/FEA tools; hands-on measurement; data analysis; cross-disciplinary collaboration.
Lumerical, Tidy3D, COMSOL, Synopsys OptoDesigner, HFSS, CST, JMP, Python, VNAs, Oscilloscopes, Swept Lasers
2w
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Lead Cloud Security/AppSec Engineer
Cambridge, Massachusetts, United States
$148k-$204k/yr OnsiteFull Time
5+ YOE5+ years in cloud security or security engineering; strong AWS security services; AppSec in CI/CD; IaC and scripting; AI-augmented security workflows; excellent collaboration with I&O and engineering teams.
AWS Security Hub, GuardDuty, IAM, SCPs, CloudTrail, Wiz, SAST, DAST, SCA, Terraform, Python, Bedrock, EKS, LLM APIs, agentic orchestration frameworks
1w
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Technical Lead - Collixoin Therapeutics
Cambridge, Massachusetts, United States
OnsiteFull Time
Lead technical development in AI and biotech; experience in computational biology, ML, Python; build deployable applications; equity-based, onsite in Boston/Cambridge.
Python, LLM API
1w
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AI Solutions Analyst- Business Architecture & Acceleration
San Francisco or Boston
OnsiteFull Time
3+ YOEApproximately 3 years in technical operations, software development, or systems integration; BS in CS or a highly technical field; strong Python and automation skills.
Python, Jira, Slack, Salesforce, LLM APIs, LangChain, LlamaIndex, Zapier, Make
2w
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Financial Advisory Senior AI Solution Architect (Nationwide, Remote)
New York or Denver or Georgia or Pennsylvania or Boston or Chicago or Houston or Dallas or Seattle or Detroit or New Jersey or California
$165k-$215k/yr RemoteFull Time
8+ YOE8–12 years in software engineering/AI development; Python expert; experience with LLM APIs, document processing; cloud deployments (AWS/Azure); CI/CD; strong communication.
Python, LLM APIs, API development, PowerPoint, Excel, AWS, Azure, Git, Seismic, Salesforce, OpenSearch, SQL, python-pptx, openpyxl
2mo
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Software / Computer / Robotics Engineer – PLC & Control Systems, Ocean Products
Chelmsford, Massachusetts, United States
$75k-$115k/yr OnsiteFull Time
2+ YOEBachelor's degree in CS/CE/Robotics; 2+ years; PLC/HMI/VFD; control systems; hardware interfacing; prototyping; strong communication.
PLC programming, HMI programming, VFD programming, MATLAB, LabVIEW, Wago controllers, C/C++, Python, TCP/IP networking, DAQ, signal conditioning
1d
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Capgemini Invent / Cambridge Consultants - Engineering Co-op - Embedded Software (Burlington, MA, US)
Burlington, Massachusetts, United States
$20-$35/hr OnsiteInternship
0+ YOEPursuing BS or MS in electrical, computer engineering, computer science, or related fields; some software development experience; C/C++/Rust; MATLAB or Python; good testing and communication skills.
C, C++, Rust, MATLAB, Python
2w
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Firmware Engineering Co-Op - Fall 2026
Boston, Massachusetts, United States
$42/hr HybridAll Commitments Available
Enrolled in computer engineering, computer science, or related engineering; experience with C and Python; firmware development; embedded systems; hardware debugging; knowledge of I2C, SPI, UART; collaboration across teams.
C, Python, JTAG, Oscilloscope, Multimeter, Bus Analyzer, I2C, SPI, UART
1mo
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Machine Learning Research Scientist, Mechanical Intuition in Multimodal Models
Los Altos or Cambridge
$158k-$253k/yr HybridFull Time
PhD in a related field, strong ML pipeline development, experience with policy/ RL, Python proficiency, interest in manufacturing.
Python, Reinforcement Learning, Robotics
2mo
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Associate Principal/Forensic AI Engineer (Forensic Services practice)
Boston or Chicago or New York or Washington
$140k-$170k/yr HybridAll Commitments Available
8+ YOE8–10+ years in ML/AI, digital forensics, or related field; expertise in LLMs, synthetic media, and AI governance; strong communication for legal settings.
Python, PyTorch, TensorFlow, pandas, NumPy, scikit-learn, SQL, OpenCV, Docker, Kubernetes, AWS SageMaker, GCP Vertex AI, Azure Machine Learning, LangChain, LlamaIndex, Transformers, PEFT, DALL·E, Ffmpeg, Pinecone, Weaviate, ChromaDB, pgvector, Spark, Airflow, Snowflake, BigQuery, Redshift
1mo
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AI Specialist
Boston, Massachusetts, United States
OnsiteFull Time
Hands-on AI development, building internal AI tools, experience with LLMs, data pipelines, Python, cloud (AWS/GCP/Azure), CRM familiarity, and strong collaboration with compliance and cross-functional teams.
Python, AWS, Google Cloud Platform, Azure, Creatio, CRM, Slack, SharePoint, Notion, ETL, AI frameworks
3w
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Principal Platform Data Engineer, SAP (Cambridge, MA, US, 02142)
Cambridge, Massachusetts, United States
$175k-$237k/yr HybridFull Time
10+ YOE10+ years in data engineering; 5+ years SAP data extraction, integration, and analytics; strong SAP domain knowledge; expert in SAP extraction methods and Snowflake/dbt-based pipelines; familiarity with regulated environments.
SAP, Snowflake, dbt, Fivetran, ABAP CDS, S/4HANA, BW/4HANA, SQL, Python, Terraform, GitHub Actions, AWS, Monte Carlo
3mo
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Security Researcher / Systems Hacker
Lexington, Massachusetts, United States
$140k-$200k/yr OnsiteFull Time
3+ YOEMS or PhD in a related field with extensive systems software research and development experience; strong C/C++, Python, and assembly; security clearance eligibility.
C/C++, Python, Assembly, Rust, LLVM, QEMU, Linux
3w
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Technology Consultant 1
Boston or Princeton
$62k-$95k/yr OnsiteFull Time
Hands-on cloud experience (AWS/Azure/GCP), DevOps, Linux/Windows servers, Python/Shell scripting; IAM, Terraform, containers; Bachelor's degree or equivalent; willing to relocate/travel; US work authorization.
AWS, Azure, GCP, Terraform, Python, Linux, Docker, Kubernetes
2mo
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Post Doc - Open Rank
Worcester, Massachusetts, United States
$62k-$76k/yr OnsiteFull Time
PhD in computational biology or related field; method development or sequencing data experience; Unix/Linux and programming (C/C++, Python, Perl, R); strong communication; publications; able to work independently and in teams.
Unix, Linux, C, C++, Python, Perl, R
2mo
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Scientist I, Peptide Drug Discovery
Cambridge, Massachusetts, United States
$110k-$125k/yr OnsiteFull Time
0+ YOEPhD in Chemical Biology, Biochemistry, Chemistry, or Bioengineering; 0-2 years postdoc/industry; hands-on assay development; automation and scripting experience; ability to work cross-functionally; proficient with Python; strong data QC mindset.
Python
2w
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Catastrophe Research Manager
New York or Boston or Philadelphia or Chicago
$105k-$150k/yr OnsiteFull Time
6+ YOE6+ years catastrophe research or model development; PhD or Master’s in Climate Science, Natural Hazards, Applied Statistics; strong RMS background; proficient in R, Python, SQL; excellent communication; experience with model reviews and validation.
R, Python, SQL
1mo
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Associate Director, MLOps (Staff AI / ML Engineer) - Hybrid
Waltham, Massachusetts, United States
$158k-$180k/yr HybridFull Time
7+ YOESenior ML/AI leader with 7+ years (MS/PhD) or 10+ years (BS) in data science/ML; strong Python, MLOps, and cloud skills; generative AI experience; able to lead cross-functional teams.
Python, Airflow, Prefect, Docker, Github, Github Actions, DataDog, AWS, GCP, LangGraph, Pydantic, FastAPI, Snowflake Cortex, DBT, Spark
1mo
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Manager, Engineering
Raleigh or Chicago or Franklin or Boston
$148k-$175k/yr HybridFull Time
5+ YOE5+ Mgmt5+ years of technical leadership; 5+ years in operations optimization; tests, reports, and documentation experience; strong Python, Django, PySpark, ETL, SQL skills.
Python, Django, PySpark, ETL, SQL
2w
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Associate Director, Programming (Macros & Automation)
King of Prussia or Waltham or Glattbrugg
$189k-$220k/yr HybridFull Time
10+ YOE10+ years SAS programming, macro development, and automation leadership; knowledge of CDISC; strong collaboration.
SAS, SAS Macro, Python, R
2w
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Member of Technical Staff - Product Engineer (Internal Data & Agent Platform)
San Francisco or Cambridge or Germany
HybridFull Time
5+ YOE5+ years software engineering; experience building data pipelines, integrations, or internal platforms; hands-on LLM production experience; strong Python; TypeScript for frontend/tooling; experience integrating SaaS APIs.
Python, TypeScript, Slack API, GitHub API, Google Workspace API, HRIS API
3d
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Senior Tools Programmer
Boston, Massachusetts, United States
$119k-$218k/yr HybridFull Time
Extensive production C++ experience; full lifecycle tool development; strong communication; prioritize and deliver value.
C++, Unreal Engine, Slate, Editor Utility Widgets, Python, Blueprint
1mo
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Staff Computational Biologist
Lexington or United States
$166k-$195k/yr HybridFull Time
6+ YOE6+ years in computational biology/data-driven discovery; 1+ year in software/data engineering; Python and R; omics/translational analysis; ETL pipelines; product-owner experience.
Python, R, Omics data analysis, ETL pipelines
3mo
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Analog Design Automation Intern
Toronto or Boston or Austin or Santa Clara
$35-$70/hr HybridInternship
Co-op or PEY student in Electrical Engineering with analog IC design exposure; Python proficiency; interest in ML concepts; open source tools; strong analytical and communication skills.
Python
2mo
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Solutions Architect
Boston or San Francisco
HybridFull Time
Strong systems thinking and coding; production systems; Python/Go/C++; web frameworks; PostgreSQL/Redis; REST/GraphQL; PyTorch/JAX; Kubernetes/Docker; Terraform; HPC/physics interest.
Python, Go, C++, React, TypeScript, Next.js, PostgreSQL, Redis, REST, GraphQL, PyTorch, JAX, Ray, Airflow, Argo, Docker, Kubernetes, Terraform, Prometheus, Grafana
1mo
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Manager, Data Science (GenAI Solutions & ML Engineering) (Boston, MA, US, 02110)
Boston, Massachusetts, United States
$131k-$164k/yr OnsiteFull Time
5+ YOE3+ MgmtBachelor’s degree; 5+ years in Machine Learning Engineering, Applied AI, or MLOps; 3+ years leading technical teams; strong end-to-end AI systems; Python and PyTorch; enterprise integration.
Python, PyTorch, ML frameworks
5d
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Brain Computer Interface R&D Intern - Brain proxy development
Cambridge, Massachusetts, United States
OnsiteAll Commitments Available
Pursuing or recently completed degree in bioengineering, mechanical engineering, or related field; CAD experience; Python/data analysis helpful; CPT-eligible for international students.
Onshape, SolidWorks, Fusion 360, 3D printing, Python
1mo
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Senior Scientist – Computational siRNA Lead Development
Dublin or Boston or Stevenage
RemoteFull Time
2+ YOEPhD in computational biology or related; extensive drug discovery in RNA-targeted therapeutics; hands-on transcriptome off-target analysis; strong Python/R; experience building computational workflows.
Python, R, RNA-seq analysis
4w
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AI Integrator #1744026
Chicopee, Massachusetts, United States
$168k-$197k/yr OnsiteFull Time
12+ YOEBachelor's in Engineering/CS; 12+ years software/architecture/data; 5+ years AI/ML; TensorFlow/PyTorch/scikit-learn/Keras; Spark/Databricks/Hadoop; Python/Django; REST/GraphQL; Docker/Kubernetes; DevSecOps; CAC eligibility; US citizenship.
TensorFlow, PyTorch, scikit-learn, Keras, Apache Spark, Databricks, Hadoop, PostgreSQL, Python, Django, Celery, Linux, REST, GraphQL, MQTT, Docker, Kubernetes, CI/CD, DevSecOps
1w
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Pioneering Intelligence Machine Learning Co-Op
Cambridge, Massachusetts, United States
$25-$40/hr OnsiteInternship
Fluency in Python with deep learning (PyTorch/JAX); ability to dive into biology/chemistry/physics of platform companies.
Python, PyTorch, JAX, Git, AWS, GCP, Azure
1mo
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Research Intern – Advanced Solution Development
Framingham, Massachusetts, United States
OnsiteInternship
Master’s or PhD candidate in CS or related field; strong AI/ML background; proven research ability; prior software development preferred.
LLM, Python, Machine Learning, Research Frameworks
1mo
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Process Development Principal Scientist
Cambridge, Massachusetts, United States
$155k-$184k/yr OnsiteFull Time
2+ YOEPhD/PharmD/MD with 2+ years, or MSc with 5 years, or BSc with 7 years; strong drug product formulation and process development, regulatory submissions.
Python, R, MATLAB, SQL, Tableau, Spotfire, D3js, SAS, JMP, Minitab
3mo
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Internship - Active SLAM for Aerial Robots
Cambridge, Massachusetts, United States
$6k-$8k/mo OnsiteInternship
PhD student in engineering/CS with hands-on aerial-robot experience; ROS2, Python/C++, and strong research potential.
Python, C++, ROS2, Isaac Sim, MuJoCo
2mo
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Scientist II, Bioinformatics
Lexington, Massachusetts, United States
$126k-$158k/yr OnsiteFull Time
Cystic Fibrosis Foundation: Funds medical research and provides support for cystic fibrosis.
PhD or Master’s with 5+ years in computational research; experience with NGS, multi-omics, R/Python, ML; strong communication.
R, Python, Shell, Linux, Git
3mo
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Computational Scientist I - Computational Biology
Cambridge, Massachusetts, United States
$88k-$124k/yr OnsiteFull Time
1+ YOEPhD in computational fields; 1+ year postdoctoral experience; Python/R programming; ML knowledge; NGS pipelines expertise.
Python, R, Machine Learning, Single-cell RNA-Seq, Single-cell ATAC-Seq, Spatial Transcriptomics, Genomics, Bioinformatics
1w
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Scientist I - R&D Next Generation Sequencing
Westborough, Massachusetts, United States
$100k-$115k/yr OnsiteFull Time
1+ YOEPhD in Molecular Biology/Genetics/Biochemistry/Chemistry or Biomedical Engineering; 1+ years in molecular assays/NGS; 6+ months in R or Python.
Next Generation Sequencing, R, Python, Bioinformatics, Molecular Diagnostics
1mo
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Intern, Computational Biology
Boston, Massachusetts, United States
$30-$33/hr OnsiteInternship
Pursuing PhD/MS in relevant field or BS with industry experience; modeling biology; Python; Unix; HPC/cloud a plus; strong collaboration.
Python, Git, Linux, AWS, HPC, Shell Scripting
HiringCafe market data
Python Developer Jobs market signals in Lancaster, MA, US
These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.
Open jobs
2,100+
Hiring companies
540+
Fresh sample
41% new in 30d
Salary visibility
80% show pay
Companies appearing in this market
AmgenBroad InstituteFlagship PioneeringMitsubishi Electric Research LaboratoriesAIGLiquid AIAlnylamCD PROJEKT RED
Work location mix in visible results
Onsite: 37Hybrid: 19Remote: 5