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Python Developer Jobs in Santee, CA, US
1,000+ python developer jobs from 180+ companies hiring in Santee, CA, US.
1mo
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Geotechnical Earthquake Engineer
San Francisco or Oakland or Los Angeles or San Diego or Irvine or Sacramento
$81k-$101k/yr OnsiteFull Time
1+ YOEBachelor’s degree in Civil/Geotechnical Engineering; 1–3 years’ experience; knowledge of geotechnical earthquake engineering; familiarity with seismic hazard analysis; strong communication and teamwork.
DEEPSOIL, RSSeismic, ArcGIS, Slide, SLOPE/W, Python, Matlab
2mo
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Principal Propulsion Engineer, UAS Systems
Arlington or Mountain View or San Diego
$165k-$245k/yr HybridFull Time
10+ YOE10+ years propulsion experience; propulsion integration; turboprop/small turbofan experience; engine performance, installation effects, and mission sizing.
MATLAB, Python, MBSE, Cameo
4d
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Senior Platform Engineer - M365
Vienna or Winchester or San Diego or Pensacola
$115k-$180k/yr HybridFull Time
5+ YOEBachelor's degree and 5-7 years in platform/Cloud engineering; CI/CD; Microsoft 365; scripting; configuration management; platform-related experience.
AWS, Azure, GCP, PowerShell, Python, Bash, Microsoft Graph, CI/CD tools, SharePoint Online, OneDrive, Microsoft Purview, Entra ID, M365 governance
6d
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Knowledge Engineer / Semantic Expert for AI
Mountain View or Milwaukee or Dallas or Columbus or Kirkland or Cincinnati or New York or Cleveland or Oklahoma City or Austin or Albany or Chicago or St. Petersburg or Hartford or Pittsburgh or St. Louis or Miami or Sacramento or Raleigh or Minneapolis or Scottsdale or San Francisco or Morristown or Denver or Boston or Philadelphia or Des Moines or Overland Park or Los Angeles or Charlotte or Walnut Creek or Carmel or Seattle or Houston or Arlington or Atlanta or Redmond or Bentonville or Beaverton or Nashville or Detroit or San Diego
HybridFull Time
12+ YOELead Knowledge Graph and AI solutions; design ontologies; build end-to-end data pipelines; team leadership; strong RDF/graph DB expertise.
RDF, SPARQL, LPG, SHACL, Neo4J, Stardog, Amazon Neptune, Python, TensorFlow, PyTorch, Airflow, NiFi, LLMs
1w
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AI Development Lead
San Diego, California, United States
HybridFull Time
Hands-on AI development lead building AI-powered features; strong Python, AI/ML, API, and cloud experience; collaborative and execution-focused.
Python, JavaScript, PyTorch, TensorFlow, LangChain, REST APIs, Cloud Platforms, Docker, Kubernetes, SQL, Vector databases
12h
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Electrical Engineer (San Diego, CA, US, 92121)
San Diego, California, United States
OnsiteFull Time
2+ YOEBachelor’s degree in engineering and 2+ years in test engineering or related field; strong knowledge of MIL-STD-461 and regulatory testing (CE/UL); power electronics experience; high-voltage testing safety.
TestStand, Python, Oscilloscopes, Multimeters, Spectrum analyzers, Power Meter
1w
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Sr Principal Research Engineer
San Diego, California, United States
$167k-$248k/yr HybridFull Time
8+ YOEPhD in Physics, Applied Physics, or Electrical Engineering with 8 years experience; or Bachelor's with 15 years; Master's with 12 years; U.S. Citizenship with ability to obtain security clearance; strong remote sensing, AI/ML, and cross-domain collaboration skills.
Remote Sensing, Machine Learning, Radar, Quantum Sensing, Networking, Python
3w
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Senior Dev Ops Engineer
San Diego, California, United States
$100k-$139k/yr HybridFull Time
DevOps/SRE with Kubernetes, AWS, Terraform; IaC; databases; scripting; strong comms; on-call readiness.
Kubernetes, Helm, AWS, Terraform, Observability, MySQL, PostgreSQL, Redis, Shell, Python
2w
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Senior NPI Test Engineer
San Diego, California, United States
$117k-$167k/yr HybridFull Time
8+ YOEBachelor's in Electrical or Computer Engineering; 8+ years semiconductor test; 5+ years mixed-signal/RF test; proven NPI leadership for high-speed ICs.
Advantest V93000, SmarTest, Teradyne uFlex, C/C++, Python, TCL, Cadence, Altium, RF/microwave test, SUT/DFT
13h
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Firewall Security Networking Engineer
Chicago or San Francisco or Los Angeles or San Diego or Seattle
$120k-$140k/yr HybridFull Time
5+ YOEBachelor’s degree in CS/EE/CE or related field; firewall expertise (Palo Alto, Check Point); network design and troubleshooting; strong communication.
Palo Alto Firewall, Check Point Firewall, Panorama, Prisma, StrataCloud, tcpdump, Wireshark, Python, Ansible, Terraform, AWS, GCP, Azure
3w
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Senior Transmission Line Engineer 1 - Grid
San Diego, California, United States
$82k-$126k/yr HybridFull Time
5+ YOEABET-accredited engineering program degree; PLS-CADD proficiency; 5+ years of project-team experience in transmission line design and related activities; knowledge of ROW, conductor sag/tension, and construction documents; strong communication and detail orientation.
PLS-CADD, MS Office, AutoCAD, MicroStation, ArcGIS, CDEGS, PLS-TOWER, SAG10, LPILE, MFAD, Python, MATLAB, Excel
2mo
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Partner Support Escalation Engineer (Contract)
Carlsbad or United States
$95k-$115k/yr RemoteFull Time
3+ YOE3+ years in partner engineering or technical support; IoT device troubleshooting; cloud platforms (AWS/GCP/Azure); networking; mobile apps; log analysis; Jira/Salesforce.
AWS, GCP, Azure, Splunk, Datadog, CloudWatch, Jira, Confluence, Salesforce, Wi-Fi, NAT, DNS, firewalls, REST APIs, Webhooks, OAuth, Python, Bash
4w
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Senior Systems and Test Engineer
Escondido, California, United States
$137k-$156k/yr OnsiteFull Time
7+ YOE7+ years Systems/Electrical/Computer engineering experience; BS in related field; strong Linux, scripting, test and design verification skills.
Linux, Python, Bash, SolidWorks, Allegro, NVMe, PCIe
2w
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Senior Computational Chemist
Cambridge or La Jolla
$106k-$177k/yr HybridFull Time
PhD in computational chemistry or related field; strong cheminformatics; Python, RDKit; ML experience; data pipeline and software development skills.
Python, RDKit, NumPy, Pandas, SQL, Rest API, GitHub, SLURM, AWS, GCP
1mo
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System Engineering Integration and Test (SEIT) Engineer
San Diego, California, United States
OnsiteFull Time
Strong systems engineering background; ability to obtain Secret clearance; STEM degree or equivalent; experience with Jira, DOORs, and Office tools; systems integration and testing experience.
Jira, DOORS, Microsoft Office, Python, Matlab, Node.js, React
1mo
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Algorithm Intern
La Jolla, California, United States
$22-$25/hr HybridFull Time
0+ YOEPhD student with hands-on deep learning/model development in medical imaging; proficient in Python and DL frameworks; strong communication and collaboration skills.
Python, PyTorch, TensorFlow
4w
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Senior Computational Development Scientist
San Diego or South San Francisco or United States
$162k-$178k/yr RemoteFull Time
6+ YOEPh.D. in a quantitative field or MSc with 3+ years; 6+ years biotech/regulatory experience; NGS-based clinical assay development; Python production pipelines; CAP/CLIA/IVD design control; strong bioinformatics
Python, R, AWS, SQL, Data analysis pipelines
1w
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Research Scientist - Research - Grant Funded
San Diego, California, United States
$57-$83/hr HybridFull Time, Contract
3+ YOEThree to five years grant development/management; statistical modeling; large-scale omics/clinical/imaging data; R/Python/SAS/SPSS; SQL/ETL skills; strong communication.
R, Python, SPSS, SAS, SQL, ETL, data modeling, computing
3w
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AI Agent Builder
Carlsbad or Scottsdale or Austin or Charlotte or Chicago
RemoteFull Time
5+ years Python/JSON/JavaScript; experience with AI platforms and APIs; web and data skills; knowledge of MarTech is a plus.
Python, JSON, JavaScript, APIs, Webhooks, HTML, CSS, SQL, Firebase, Power Automate, Copilot, Claude, Codex, n8n
3w
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Senior Technical Artist: Procedural Art
Carlsbad or Leeds or Oakville
$105k-$140k/yr OnsiteFull Time
5+ YOE5+ years as Technical Artist/Tools Programmer; expert in photogrammetry workflows; Python; build systems; DCC tools; ML pipelines.
Houdini, Zbrush, Agisoft, Metashape, Python, Jenkins, Airflow, Celery
1d
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Applied Perception Engineering Lead
Ann Arbor or San Diego
$175k-$210k/yr OnsiteFull Time
8+ YOE2+ MgmtLed software team; 8+ years in perception or ATR/ML; 2+ years leadership; C++/Python; experience deploying to hardware; robotics/autonomy.
C++, Python
1mo
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Software Engineering Manager
Aliso Viejo or Fort Myers or Durham or Carlsbad
RemoteFull Time
5+ YOE3+ Mgmt5+ years leading application development; 3+ years managing engineers; healthcare/clinical system experience preferred.
.NET, Python, Microsoft SQL Server, Vue.js, React, Azure, EHR, FHIR, HL7, APIs
1w
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Sr/Principal Scientist, Computational Chemistry
San Diego, California, United States
$138k-$190k/yr OnsiteFull Time
5+ YOEPhD in computational chemistry with 5+ years in industry; experience in ligand and structure-based design; Python proficiency.
Python, MOE, Molecular Dynamics, MM/GBSA, Machine Learning
2mo
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Scientist / Senior Scientist, Multimodal AI
Redwood City or San Diego
OnsiteFull Time
PhD in CS/AI/ Biomedical Eng; cv architectures; distributed training; Python; publications; cloud MLops; multimodal fusion (preferred).
Python, PyTorch, DeepSpeed, JAX, Kubernetes, Docker, AWS, GCP, Distributed Training, MLops
1mo
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Sr. Scientist I, Translational Genetics & Real-World Evidence
San Diego, California, United States
$145k-$165k/yr OnsiteFull Time
3+ YOEPhD in quantitative bioscience; 3+ years genetics/data science; AI/LLMs experience; biobank/EHR data experience; R/Python; strong communication.
R, Python, OMOP OHDSI, EHR, biobank datasets, AI/LLMs
2w
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Principal Scientist, Computational Pathobiologist
Spring House or La Jolla
$117k-$201k/yr HybridFull Time
6+ YOE6+ years data science/biostatistics for multimodal biomedical data; Python and/or R; cloud deployment; AI/ML; data visualization; understanding of biomedical context.
Python, R, GCP, Azure, AWS, Snowflake, Posit Connect, Spotfire, Power BI, R Shiny, AI, Machine Learning, AlphaFold
1w
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Scientist I, Computational Chemistry
San Diego, California, United States
$120k-$135k/yr OnsiteFull Time
PhD in computational chemistry; pharma/biotech drug discovery experience; expertise in molecular modeling; Python; docking/MD/QM; strong communication; team player.
Schrodinger Suite, OpenEye, CCG, Python
2mo
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Manager, Algorithms
San Diego, California, United States
$173k-$200k/yr HybridFull Time
5+ YOEPhD or MS with strong leadership, 5+ years building sensor time-series algorithms; Python proficiency; cross-functional collaboration; strong communication and delivery mindset.
Python, Git, Code Review, Testing, Reproducibility
3mo
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Senior Manager, High-Throughput Screening Operations- San Diego, CA (United States)
San Diego, California, United States
$132k-$188k/yr OnsiteFull Time
8+ YOEPh.D. in Molecular or Cell Biology, Neuroscience, Pharmacology, or related field; 8+ years in HTS; proven leadership; HTS/automation expertise; GPCR/ion channel pharmacology; data analysis (R/Python).
R, Python, Automation, HTS Instruments, Liquid Handling, Assay Development
1mo
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Vertex Fall Co-op 2026, Data and Computational Sciences
San Diego, California, United States
$30-$50/hr OnsiteFull Time, Internship
PhD students in computational chemistry or related STEM; Python scripting; MD simulations; strong communication; onsite full-time in San Diego; US work authorization; available July–December 2026.
Python, Perl, R, Bash, RDKit, OpenEye, CPPTRAJ, AMBER, OpenMM, FEP, Statistics
1mo
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Senior Manager, Intelligence Systems Lab
Princeton or Bothell or San Diego or Seattle
$134k-$178k/yr HybridFull Time
3+ YOEResearch and develop agentic AI systems; benchmarking; cross-functional collaboration; 3+ years in data science/AI; experience in pharmaceutical or life sciences preferred.
Python, Scikit-Learn, TensorFlow, PyTorch, LangGraph, Strands, DSPy, AutoGen, DSPy, RAG, SQL, AWS, Azure, GCP, Git
1mo
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Audio-Visual Systems Programmer
San Diego, California, United States
$95k-$125k/yr OnsiteFull Time
FORTÉ: Designs and installs audiovisual and collaboration technology for workplaces.
Troubleshoot and program complex AV systems; install AV hardware; knowledge of DSP, switchers, Dante/AES-67; Crestron/Extron/Q-SYS programming; strong communication; relevant certifications preferred.
Crestron, Extron, Q-SYS, Dante, AVB, AES-67, AMX, HTML5, C#, Python, LUA, SIMPL, SIMPL+, CTS
2w
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NIWC - Undergraduate Student III - MANTA Project (Task No. 55-142608)
San Diego, California, United States
$20/hr OnsitePart Time
0+ YOEUndergraduate student with coursework in AI, data structures, algorithms, databases; available for 20 hours/week; US citizen eligible for DoD clearance.
Python, LangChain, LangGraph, TensorFlow, PyTorch, Streamlit, Plotly, Git, TOMO-sim
1mo
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NIWC - Undergraduate Student - Allied Interoperability (Task No. 55-112524)
San Diego, California, United States
$20/hr OnsitePart Time
0+ YOEUndergraduate student in Electrical/Computer Engineering or related field; open to other STEM disciplines with relevant coursework.
Python, MATLAB, C++, Git, Java, C#, Altium, KiCad, Eagle
4w
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Software Development Adjunct Instructor
Albuquerque or San Diego or New Mexico or California or Florida or Massachusetts
$38-$48/hr RemotePart Time, Temporary
3+ YOEBachelor's degree or higher; 3+ years in IT or 2+ years teaching; synchronous online teaching experience preferred; knowledge of C++, Java, JavaScript, Python, SQL, databases, iOS, Android; strong communication and organizational skills.
C++, Java, JavaScript, Python, SQL, Databases, iOS, Android
4w
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Director, Computational Biology
Carlsbad or Boston or Remote
$200k-$250k/yr HybridFull Time
8+ YOE1+ MgmtPhD in computational biology or related field; 8+ years experience; leadership experience; multi-omics expertise; strong programming.
Python, R, Bash, Docker, Nextflow, AWS
4w
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Pharmacology Research Scientist
San Diego, California, United States
$111k-$166k/yr OnsiteFull Time
0+ YOEPhD in Pharmacology or Biology with 0-3 years experience, or Master’s with 3+ years, or Bachelor’s with 6+ years in pharma/biotech; expertise in ex vivo and nervous system models; in vitro/in vivo pharmacology; data analysis; strong communication and collaboration.
GraphPad Prism, Spotfire, MATLAB, Python
1d
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Postdoctoral Research Scholar 0-5 yrs Experience
San Diego, California, United States
$6k-$6k/yr OnsiteFull Time
0+ YOEPhD in Aerospace Engineering, Applied Mathematics, Mechanical Engineering or related field; strong math, HPC, programming; experience in scientific computing; ability to work independently and in team.
HPC, Python, MATLAB, C++
3w
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Scientific Fellow, AI Safety, R&D Data Science and Digital Health
Titusville or Cambridge or Spring House or San Diego
$196k-$343k/yr HybridFull Time
10+ YOEPhD or equivalent; 10+ years in AI; strong AI safety expertise; interdisciplinary collaboration; life sciences experience preferred.
Python, Machine Learning, AI safety, Generative AI, Agentic systems
5d
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AI & Data Solutions Analyst
San Diego, California, United States
$100k-$130k/yr RemoteFull Time
3+ YOE3-6 years data engineering/analytics platform experience; cloud data pipelines; AI agent development; CRE domain experience preferred.
Microsoft Fabric/OneLake, SQL, Python, Azure OpenAI Service, Azure AI Search, Copilot Studio, Power BI, Power Automate, APIs, Git
HiringCafe market data
Python Developer Jobs market signals in Santee, CA, US
These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.
Open jobs
1,000+
Hiring companies
180+
Fresh sample
61% new in 30d
Salary visibility
81% show pay
Companies appearing in this market
PfizerSan Diego State University Research FoundationAltos LabsBristol Myers SquibbIambic TherapeuticsJohnson & JohnsonRockstar GamesVeracyte
Work location mix in visible results
Onsite: 30Hybrid: 28Remote: 6