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Python Software Developer Jobs in Natick, MA, US
1,000+ python software developer jobs from 330+ companies hiring in Natick, MA, US.
2mo
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Temporary Online Course Developer –RITM 115 Programming for Systems Automation & Data Workflows
Waltham, Massachusetts, United States
$3k/bi-wk RemotePart Time
3+ YOEMaster’s degree in CS/Software/IS/Data Eng or related; 3+ years automation programming; strong scripting in Python/PowerShell/Bash/JavaScript; LMS experience; remote course development for graduate/adult learners.
Python, PowerShell, Bash, JavaScript, Airflow, Prefect, Azure Data Factory, AWS Step Functions, Moodle, H5P
2w
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Financial Advisory Senior AI Solution Architect (Nationwide, Remote)
New York or Denver or Georgia or Pennsylvania or Boston or Chicago or Houston or Dallas or Seattle or Detroit or New Jersey or California
$165k-$215k/yr RemoteFull Time
8+ YOE8–12 years in software engineering/AI development; Python expert; experience with LLM APIs, document processing; cloud deployments (AWS/Azure); CI/CD; strong communication.
Python, LLM APIs, API development, PowerPoint, Excel, AWS, Azure, Git, Seismic, Salesforce, OpenSearch, SQL, python-pptx, openpyxl
6d
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Hardware Test Engineer
Boston, Massachusetts, United States
$102k-$126k/yr OnsiteMultiple Commitments Available
3+ YOE3+ years in hardware-software integration testing; owns test plans; reliability testing; statistical methods; data acquisition; Python/MATLAB/JMP; strong docs and communication; interpret drawings/schematics.
Python, MATLAB, JMP, LabVIEW, DataQ, JIRA, Confluence, SolidWorks, 3D printing
2mo
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AI Data Engineer--LLMs / Agentic Systems
Cambridge, Massachusetts, United States
$106k-$172k/yr HybridFull Time
2+ YOEPhD or Masters with AI-focused experience; 2+ years Python/TypeScript; production-grade software; portfolio; strong collaboration skills.
Python, TypeScript, FastAPI, React, OpenAI API, Hugging Face Transformers, Anthropic Claude, PyTorch, AWS, Docker, GitHub Actions
3w
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Staff Site Reliability Engineer
Boston, Massachusetts, United States
$180k-$225k/yr HybridFull Time
10+ YOE10+ years in software engineering; infrastructure/platform/reliability focus; proficient in Go/TypeScript/Python/Java; IaC (Terraform/CDK/CloudFormation); SRE tooling; security and IAM; experience with distributed systems.
Go, TypeScript, Python, Java, Terraform, CDK, CloudFormation, SSO/OIDC, RBAC, ABAC, Secrets management, Key management
1mo
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Programmer Analyst
Boston, Massachusetts, United States
$64k-$91k/yr OnsiteFull Time
Mass General Brigham: Provides integrated medical care, research, and clinical training services.
Proficient in Python, R, JavaScript; performance-focused software development; cross-platform; strong data modeling and analysis skills; bachelor’s degree in CS, Math, Data Science, Statistics, Computational Biology, or related field.
Python, R, JavaScript, C/C++, Linux, Windows, macOS, SQL
2mo
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Lead AI Engineer (Boston, Massachusetts, US)
Boston, Massachusetts, United States
$150k-$180k/yr HybridFull Time
5+ YOE5+ years software or ML engineering; 2+ years building production LLM systems; expert Python; TypeScript or Go; experience with RAG, Snowflake Cortex, and enterprise data tooling.
Python, TypeScript, Go, Snowflake, dbt, AWS, Snowpark, Cortex, SageMaker, MLflow, WeDevs, Weights & Biases, Airflow
3mo
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Application Engineer
San Jose or Cary or Austin or Burlington
$74k-$138k/yr OnsiteFull Time
0+ YOEEntry-level engineer, full-time, cohort program with rotations in digital design, verification, HDL, and software/hardware co-design; hands-on training in design and scripting.
UNIX, C/C++, Python, Perl, TCL, HDL, Scripting
1mo
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FPGA Engineer (MA, Boston)
Boston, Massachusetts, United States
OnsiteFull Time
EndoSec: Security software and cryptographic hardware for government and defense.
RTL, C/C++, Python, VHDL, Verilog, Tcl, cryptography, hardware, embedded software, System Integration, Hardware Security, Xilinx, Simulation, IP core, Versal, Stratix, Vivado, GHDL, Questa, Quartus Prime, Zynq, Agilex, AXI, ACE, Avalon, FPGA verification tools, reverse engineering, cocotb, pyuvm. Travel up to 10%. Must obtain/maintain U.S. Governme...
C, C++, Python, VHDL, Verilog, Tcl, Vivado, GHDL, Questa, Quartus Prime, Zynq, Versal, Stratix, Agilex, AXI, ACE, Avalon, Cocotb, pyuvm
2w
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Staff Platform Engineer
Boston, Massachusetts, United States
$183k-$227k/yr OnsiteFull Time
8+ YOE8+ years software engineering; 4+ years Kubernetes at scale; strong AWS, CI/CD, IaC (Terraform/CloudFormation); programming in Python/Java/Go/JavaScript; cloud security and monitoring expertise; excellent communication.
AWS, Kubernetes, Terraform, CloudFormation, GitHub Actions, ArgoCD, Argo Workflows, Jenkins, CircleCI, Grafana, CloudWatch, Prometheus, Terraform
1mo
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Senior Systems Test Engineer, Abiomed
Danvers, Massachusetts, United States
$109k-$196k/yr OnsiteFull Time
5+ YOEBS or MS in Electrical, Mechanical, Software, Biomedical Engineering or related field; minimum 5 years of Verification & Validation; hands-on with test stands, data acquisition; proficient in LabVIEW, MATLAB, Python; experience with UART/USB/CAN; strong statistical/data analysis.
LabVIEW, Matlab, Python, Oscilloscopes, Multi-meters, Function Generators, Power Supplies, Data Acquisition Systems
1w
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Technical Lead - Collixoin Therapeutics
Cambridge, Massachusetts, United States
OnsiteFull Time
Lead technical development in AI and biotech; experience in computational biology, ML, Python; build deployable applications; equity-based, onsite in Boston/Cambridge.
Python, LLM API
1mo
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Staff Computational Biologist
Lexington or United States
$166k-$195k/yr HybridFull Time
6+ YOE6+ years in computational biology/data-driven discovery; 1+ year in software/data engineering; Python and R; omics/translational analysis; ETL pipelines; product-owner experience.
Python, R, Omics data analysis, ETL pipelines
4w
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AI Technical Architect
New York or Chicago or Boston
$120k-$140k/yr HybridFull Time
9+ YOEBachelor's or master's in CS/DS/Engineering; 9-10 yrs AI/ML experience; strong Python, SQL/NoSQL; ML/AI development & deployment; cloud (AWS/Azure/GCP); GenAI exposure; API development; math/statistics knowledge.
Python, SQL, NoSQL, TensorFlow, PyTorch, Scikit-learn, OpenCV, Keras, Flask, Django, AWS, Azure, GCP, OpenAI, Google Gemini, Runway ML, Vector DB/Embeddings, LLM
1mo
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Robotics/UAS Engineer II/III
Wilmington, Massachusetts, United States
$90k-$171k/yr OnsiteFull Time
Robotics/UAS Engineer with experience in unmanned systems, hardware-software integration, and flight testing.
CAD (NX or similar), Embedded systems, ROS, PX4, ArduPilot, Python, C++
2w
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Firmware Engineering Co-Op - Fall 2026
Boston, Massachusetts, United States
$42/hr HybridAll Commitments Available
Enrolled in computer engineering, computer science, or related engineering; experience with C and Python; firmware development; embedded systems; hardware debugging; knowledge of I2C, SPI, UART; collaboration across teams.
C, Python, JTAG, Oscilloscope, Multimeter, Bus Analyzer, I2C, SPI, UART
1mo
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AI Specialist
Boston, Massachusetts, United States
OnsiteFull Time
Hands-on AI development, building internal AI tools, experience with LLMs, data pipelines, Python, cloud (AWS/GCP/Azure), CRM familiarity, and strong collaboration with compliance and cross-functional teams.
Python, AWS, Google Cloud Platform, Azure, Creatio, CRM, Slack, SharePoint, Notion, ETL, AI frameworks
1mo
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Associate Level Mechanical Engineer (Ph.D.)
Natick, Massachusetts, United States
$135k-$160k/yr OnsiteFull Time
Ph.D. in mechanical-related field; experience analyzing machine components; strong fundamentals in statics, dynamics, and solid mechanics; proficiency with engineering software; willingness to travel; strong communication and leadership potential.
LabView, Matlab, Python, MathCAD, Solidworks, AutoCAD
1mo
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Payer Dev, Git & ML-Ops Engineer, Senior Associate
Boston or Indianapolis or Raleigh or Charlotte or Jacksonville or Chicago or Cincinnati or Cleveland or Columbia or Kansas City or Columbus or Dallas or Las Vegas or Los Angeles or Baltimore or Birmingham or St. Louis or Salt Lake City or San Diego or San Francisco or Silicon Valley or Seattle or Stamford or Tampa or Toledo or Austin or Washington or New York or Florham Park or Philadelphia or Phoenix or Pittsburgh or Houston
$77k-$202k/yr OnsiteFull Time
4+ YOEBachelor's degree; 4+ years software or data engineering; experience with dbt on Databricks; healthcare analytics experience; CI/CD pipelines for Databricks; Azure Databricks workspace provisioning; Python CLI tools.
Databricks, dbt, Azure Databricks, Python, YAML, argparse, CI/CD, AI agent systems
2mo
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Client Engineer III (MedInsight)
Seattle or Appleton or Atlanta or Boise or Wakefield or Chicago or Dallas or Hartford or Omaha or San Francisco or Portland or Portland
$85k-$162k/yr RemoteFull Time
5+ YOE5+ years in analytics/data engineering with client-facing delivery; expert SQL; dimensional modeling; strong software engineering practices; able to lead data-driven implementations.
SQL, Git, CI/CD, ETL, Data Modeling, Python, Cloud
2w
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Sr. Digital Manufacturing Technical Specialist
Norwood, Massachusetts, United States
$100k-$161k/yr HybridFull Time
2+ YOEBS/MS in CS/Engineering/Data Science; 2-4 yrs AI/ML in production; strong software engineering; GenAI/LLM; cloud platforms; US work authorization.
Cloud platforms, Generative AI, LLM, APIs, RAG, Python, Software engineering
1mo
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R&D Measurement & Automation Engineer
Devens, Massachusetts, United States
$90k-$145k/yr OnsiteFull Time
5+ YOEBachelor's degree in electrical engineering, physics, or related field; 5+ years in integration/test engineering; strong electronics hardware and software experience; willingness to travel and work nights/weekends on occasion.
LabVIEW, Ignition, TwinCAT, Beckhoff PLC, AutoCAD Electrical, AutoCAD, Python, C/C++, Test equipment (oscilloscopes, spectrum analyzers, signal generators), Industrial automation, HMI/GUI development
2w
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Senior Security Engineer, Detection and Response
Austin or San Francisco or Seattle or Boston or Washington
$182k-$202k/yr RemoteFull Time
5+ YOE5+ years in detection and response or security engineering; strong software fundamentals; experience with cloud (AWS); experience with log analysis and endpoint detection tools.
Python, Go, Ruby, CloudTrail, GuardDuty, VPC flow logs, Datadog, Splunk, ELK, SentinelOne, CrowdStrike
1w
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Site Reliability Engineer I
Boston or Milwaukee or Maitland
$53k-$90k/yr HybridFull Time
1+ YOE1-3 years of experience in SRE, Technical Support, or Software Engineering; Bachelor's degree in Computer Science or Computer Engineering or equivalent experience; strong programming and scripting skills; cloud (AWS/Azure) experience.
C#, Java, Python, SQL, PostgreSQL, AWS, Azure, Git
1w
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Systems Engineer IV (West Greenwich, RI, US, 02817)
West Greenwich, Rhode Island, United States
$44k-$103k/yr OnsiteFull Time
9+ YOESenior systems engineer for architecting and implementing enterprise-scale software and infrastructure; leads design, standards, and mentoring.
Red Hat Linux, Windows Server, OpenShift, VMware ESXi, vSphere, IBM DB2, PostgreSQL, OpenLDAP, Red Hat IDM, Puppet, Ansible, AWS, Azure, Google Cloud, NetApp, Lenovo DM Storage, Ansible Playbooks, Red Hat Satellite, KSH, bash, Python, Java, Ruby
1mo
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Manager, Engineering
Raleigh or Chicago or Franklin or Boston
$148k-$175k/yr HybridFull Time
5+ YOE5+ Mgmt5+ years of technical leadership; 5+ years in operations optimization; tests, reports, and documentation experience; strong Python, Django, PySpark, ETL, SQL skills.
Python, Django, PySpark, ETL, SQL
2w
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Associate Director, Programming (Macros & Automation)
King of Prussia or Waltham or Glattbrugg
$189k-$220k/yr HybridFull Time
10+ YOE10+ years SAS programming, macro development, and automation leadership; knowledge of CDISC; strong collaboration.
SAS, SAS Macro, Python, R
1mo
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Research Scientist, AI/ML Agentic Systems
Boston, Massachusetts, United States
$116k-$182k/yr HybridFull Time
PhD in computer science, computational biology, bioinformatics, or related field; experience with large language models; Python; agentic AI frameworks; RAG systems; drug discovery knowledge.
Python, LangChain, AutoGen, CrewAI, LLM, Vector databases, ChEMBL API, PubMed API
3d
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Senior Tools Programmer
Boston, Massachusetts, United States
$119k-$218k/yr HybridFull Time
Extensive production C++ experience; full lifecycle tool development; strong communication; prioritize and deliver value.
C++, Unreal Engine, Slate, Editor Utility Widgets, Python, Blueprint
1mo
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Member of Technical Staff - Applied ML, RecSys
San Francisco or Boston or Remote
HybridFull Time
Hands-on experience building or fine-tuning recommendation models at scale; sequential recommendation architectures; data quality and evaluation design; large-scale data pipelines; Python and PyTorch proficiency.
Python, PyTorch, Large-scale data pipelines, Recommendation models
3mo
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Analog Design Automation Intern
Toronto or Boston or Austin or Santa Clara
$35-$70/hr HybridInternship
Co-op or PEY student in Electrical Engineering with analog IC design exposure; Python proficiency; interest in ML concepts; open source tools; strong analytical and communication skills.
Python
2mo
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Solutions Architect
Boston or San Francisco
HybridFull Time
Strong systems thinking and coding; production systems; Python/Go/C++; web frameworks; PostgreSQL/Redis; REST/GraphQL; PyTorch/JAX; Kubernetes/Docker; Terraform; HPC/physics interest.
Python, Go, C++, React, TypeScript, Next.js, PostgreSQL, Redis, REST, GraphQL, PyTorch, JAX, Ray, Airflow, Argo, Docker, Kubernetes, Terraform, Prometheus, Grafana
1mo
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Manager, Data Science (GenAI Solutions & ML Engineering) (Boston, MA, US, 02110)
Boston, Massachusetts, United States
$131k-$164k/yr OnsiteFull Time
5+ YOE3+ MgmtBachelor’s degree; 5+ years in Machine Learning Engineering, Applied AI, or MLOps; 3+ years leading technical teams; strong end-to-end AI systems; Python and PyTorch; enterprise integration.
Python, PyTorch, ML frameworks
1mo
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Solutions Architect
Boston, Massachusetts, United States
$175k-$210k/yr HybridFull Time
7+ YOE7+ years in Solutions Architecture/Applied Engineering for enterprise SaaS or ML/LLM products; strong system design; LLM/AI familiarity; practical coding (JS/Node/TS or Python); excellent writing; CX/Support stack experience a plus.
JavaScript, Node.js, TypeScript, Python, REST, GraphQL, APIs, webhooks, ETL, iPaaS
3mo
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Security Researcher / Systems Hacker
Lexington, Massachusetts, United States
$140k-$200k/yr OnsiteFull Time
3+ YOEMS or PhD in a related field with extensive systems software research and development experience; strong C/C++, Python, and assembly; security clearance eligibility.
C/C++, Python, Assembly, Rust, LLVM, QEMU, Linux
1mo
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Research Intern – Advanced Solution Development
Framingham, Massachusetts, United States
OnsiteInternship
Master’s or PhD candidate in CS or related field; strong AI/ML background; proven research ability; prior software development preferred.
LLM, Python, Machine Learning, Research Frameworks
9h
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Applied Scientist, GenAI
Wilmington, Massachusetts, United States
$152k-$189k/yr OnsiteFull Time
Lead design and deployment of production-grade GenAI and ML systems; hands-on experience with LLM/SLM optimization, multi-agent architectures, and cloud-scale systems.
Python, Cloud Platforms, LLM tooling, Vector databases, CI/CD, Distributed systems, Docker, Kubernetes
2mo
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Algorithmic Trading Internship - Boston Summer 2026
Boston, Massachusetts, United States
$50/hr RemoteInternship
0+ YOECuriosity, self-motivation, strong communication, collaborative, problem-solving, and programming skills.
Python, C#, Java, C++
1mo
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AV Programmer
Andover, Massachusetts, United States
$105k-$130k/yr OnsiteFull Time
3+ YOEProven AV Programmer with 3+ years experience; bachelor’s preferred; strong programming skills across languages and frameworks.
C#, NET, Python, JavaScript, Lua, C++, Java, SQL, MongoDB, Flask, Django, Git, Bitbucket
1mo
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Lead AI Solutions Architect - Full Stack
Princeton or Glen Allen or Coppell or Waltham or Philadelphia or Riverwoods or New York City or Chicago or Houston
$129k-$226k/yr HybridFull Time
10+ YOELeadership-focused AI solutions architect with 10+ years in full-stack engineering, GenAI/Agentic AI, data science, AI/ML, and applied AI engineering; proven leadership and mentoring experience.
Python, FastAPI, Angular, React, LangChain, LlamaIndex, SQL, NoSQL, Azure, AWS
HiringCafe market data
Python Software Developer Jobs market signals in Natick, MA, US
These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.
Open jobs
1,000+
Hiring companies
330+
Fresh sample
43% new in 30d
Salary visibility
83% show pay
Companies appearing in this market
AxonJohnson & JohnsonLiquid AIMass General BrighamPfizerAlegeusBeviBrandeis University
Work location mix in visible results
Hybrid: 23Onsite: 19Remote: 5