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Lead Python Developer Jobs in Illinois, United States
430+ lead python developer jobs from 260+ companies hiring in Illinois, United States.
1mo
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AI Engineer
United States or North America
$130k-$140k/yr RemoteFull Time
Experienced AI engineer with production‑oriented AI/ML skills, strong software engineering fundamentals, and ability to lead AI initiatives.
Python, LLM tooling, API design, Cloud services
3w
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Staff Software Development Engineer (Cloud & AI)
Buffalo Grove or Scottsdale or Richardson
$130k-$261k/yr HybridFull Time
7+ YOE7+ years software/data delivery; 5+ years ETL/ELT; 5+ years Azure/GCP; 3+ years CI/CD; proficient in Java, Python, FastAPI, Go; PostgreSQL, Azure SQL, Cosmos DB; Kafka; 3+ years leading projects; AI tooling experience.
Java, Python, FastAPI, Go, PostgreSQL, Azure SQL, Cosmos DB, Apache Kafka, MQ, Jenkins, GitHub Copilot, Claude, Windsurf
1w
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Senior Software Engineer, Automated Trading
Chicago, Illinois, United States
$200k/yr OnsiteFull Time
Experience leading large-scale engineering projects; strong CS fundamentals; proficient in systems-level or performance-oriented programming (C, C++, Python, Linux); able to mentor others and set technical direction.
C, C++, Python, Linux
2w
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Principal Machine Learning Engineer - VoIP Infrastructure
Chicago, Illinois, United States
$236k-$413k/yr HybridFull Time
Lead design and implementation of VoIP/CCaaS integrations; build AI/ML solutions; strong VoIP, SIP/RTP, Kamailio, RTPEngine experience; Python/Go/Java; Kubernetes; distributed systems; Cloud and DevOps practices.
Kamailio, RTPEngine, FreeSWITCH, SBCs, PSTN, Python, Go, Java, Kubernetes, Helm, Ansible, Prometheus, Splunk, GitLab CI, LLM
2mo
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Senior SOC Engineer (Security Operations Technical Lead) - Remote (USA)
United States
RemoteFull Time
7+ YOESenior SOC Engineer with MSSP experience, hands-on security engineering, leading SOC processes, detection engineering, incident response, and client engagement.
EDR, XDR, MDR, CrowdStrike, SentinelOne, Blackpoint, Microsoft Defender for Endpoint, Cortex XDR, Microsoft 365 security, SIEM, SOAR, email security, vulnerability scanners, NSM tools, AWS, Azure, GCP, M365, PowerShell, Python, KQL, SPL, Elastic DSL, AQL
2mo
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Staff Software Engineer, Ads Measurement Products
San Francisco or United States
$177k-$365k/yr RemoteFull Time
8+ YOEBS+ in Computer Science or related field; 8+ years in software engineering; strong data-pipeline and distributed-systems experience; proficiency in Java/Scala/Kotlin or Python plus SQL; experience with AI enablement and AdTech/measurement products; ability to lead cross-functional initiatives.
Java, Scala, Kotlin, Python, SQL
1mo
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Lead Warehouse Design Engineer - Remote (Remote, GA, US, 99999)
United States
RemoteFull Time
4+ YOE1+ MgmtBachelor's in Engineering or related field; 4 years in supply chain/warehousing; leadership experience; proficient in Microsoft Office.
AutoCAD, SQL, Power BI, Python, Microsoft Office
2w
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Principal Security Engineer, Research & Engineering
United States or North America
$200k-$250k/yr RemoteFull Time
Extensive software development and security engineering experience in Rust, C++, and Python; leadership; client engagement; mentoring; ability to lead security research projects.
Rust, C++, Python, Go, Java
1w
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Partner Product & Solutions Lead
United States
$150k-$220k/yr RemoteFull Time
5+ YOE5+ years in technical, customer-, or partner-facing roles; deep technical fluency in AI, strong Python, cloud experience; proven partner relationships; excellent communication; startup-minded and ownership-driven.
LangChain, AgentCore, CrewAI, ADK, Azure Foundry, Python, AWS, GCP, Azure
2w
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Senior Software Engineer
United States
$150k-$200k/yr RemoteAll Commitments Available
5+ YOE5+ years of professional software engineering; experience shipping production software at scale; roles may be Senior, Staff, or Lead.
TypeScript, JavaScript, Python, AWS, PostgreSQL, Redis, Containers, CI/CD
1d
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Tech Lead Manager (Machine Learning) |M1|
United States
$196k-$247k/yr RemoteFull Time
6+ YOE6+ years in ML engineering, leadership 1+ year, strong Python/SQL, hands-on ML lifecycle, collaboration with product/eng teams, ROI-focused.
Python, SQL, MLOps, Feature Stores, Model Deployment, Monitoring
2w
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Sr. Software Engineer
United States
$99k-$168k/yr RemoteFull Time
Senior software engineer with strong OO, cloud, RESTful services, databases, and modern frameworks; lead design, mentor teammates, and collaborate with stakeholders.
REST, PostgreSQL, SQL Server, JPA, Hibernate, Entity Framework, Azure, AWS, Jira, Confluence, C++, Java, JavaScript, Python, SQL, PL/SQL, .NET, Google Web Toolkit
2mo
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Lead Site Reliability Engineer
United States
$170k-$200k/yr RemoteFull Time
5+ YOE5+ years in site reliability DevOps or cloud infra; Kubernetes; Terraform; AWS; observability; incident mgmt; automation; strong cross-functional communication.
Kubernetes, Terraform, AWS, Grafana, Prometheus, Python, Bash
2mo
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Senior AI Developer (Agentic Healthcare Application)
United States
RemoteFull Time
5+ YOELead architect for agentic AI workflows, data integration, and strategy with healthcare domain experience; strong ML/AI and cloud infrastructure skills.
LangChain, LangGraph, Vertex AI SDK, Agent Development Kit, Function Calling, Context Caching, MCP protocols, SQL, BigQuery, Vector Databases, Pinecone, Milvus, Vertex Vector Search, Python, FastAPI, Docker, Cloud Run, GKE, HIPAA/GDPR data handling
2mo
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Laboratory Operations Programming Lead - FSP
United States
RemoteFull Time
6+ YOE6+ years in lab operations or clinical research with programming experience; proficient in R, Python, Perl, SQL, MATLAB; APIs, databases, dashboards; strong communication; advanced Excel; vendor management.
R, Python, Perl, SQL, MATLAB, APIs, Database development, Dashboard development, Linux/Unix
1mo
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Quality Engineer II (Remote)
Oak Brook, Illinois, United States
RemoteFull Time
3+ YOE3-5 years in software QA, lead testing, mentoring, strong automation, Selenium/Appium/JUnit/TestNG, SQL, SDLC knowledge.
Selenium, Appium, JUnit, TestNG, SQL, XML, Java, C#, Python, JMeter, LoadRunner, ADO
1mo
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Senior IA Engineer
United States
RemoteFull Time
Senior AI engineer with GenAI expertise; cloud (Azure/AWS); Python; GenAI architectures; MLOps; lead technical initiatives.
Python, Azure, AWS, GenAI, MLOps, LLMOps, PyTorch, TensorFlow
9h
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Corporate Vice President - Senior FinOps Developer Engineer (Remote, any state, US)
United States
RemoteFull Time
3+ YOELead AWS FinOps development, cost optimization, governance; build tooling, dashboards, data pipelines; collaborate with Engineering and Finance.
AWS, AWS Cost Explorer, Savings Plans, Reserved Instances, Cost Tooling, Python, SQL, Power BI, Tableau, Impactful BI, Excel, Terraform, CloudFormation, APIs, Data Pipelines, QuickSight, Harnes CCM, Apptio, CloudCheckr, BI Visualization
1w
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Staff Data Engineer
United States
$180k-$200k/yr RemoteFull Time
7+ YOELead data engineering; design ELT pipelines; AWS; Python; SQL; Dagster; Snowflake; HIPAA.
AWS, Dagster, Terraform, Snowflake, Python, SQL, Lambda, SQS, SNS, S3
2mo
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Principal Software Engineer, Corporate AI
Canada or Mexico or United States
RemoteFull Time
12+ YOELead AI/ML, automation, and data platforms; 12+ years software engineering; strategic technical leadership; mentor engineers.
Python, Java, Go, Scala
1w
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Principal Scientist Algorithm Lead
United States
RemoteFull Time
8+ YOEPhD in a quantitative field; 8+ years in clinical NGS algorithms; leadership in validation and regulatory submissions; proficient in Python and R; ML/AI experience with NGS data.
Python, R, Workflow orchestration, Validation automation
1mo
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Business Intelligence Lead, People Analytics
United States
$119k-$189k/yr RemoteFull Time
6+ YOE8+ years in BI/analytics, dashboard development in Tableau/BI, strong SQL, Python or R, stakeholder collaboration.
Tableau, Databricks, SQL, Python, R
2mo
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Principal Software Engineer, D2C Growth
United States
$205k-$285k/yr RemoteFull Time
12+ YOE12+ years of software engineering; 5+ years as lead engineer; track record delivering large projects; strong communication; cloud experience; degree in CS or related field.
Node.js, Python, LangChain, LLM integration, Databricks
6d
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Senior DevOps Engineer, Team Lead
United States
$230k-$250k/yr RemoteFull Time
5+ YOE4+ Mgmt5+ years in DevOps or related role; strong cloud experience (AWS/GCP/Azure); containerization (Docker, ECS/Kubernetes); CI/CD; monitoring/logging; IaC; security and performance focus; strong communication; Bachelor's in CS or related field.
AWS, GCP, Azure, Docker, ECS, Kubernetes, Gitlab, Github Actions, Terraform, Ansible, CloudFormation, Datadog, Prometheus, Grafana, Bash, Python, Go
7h
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Team Lead, Government-Wide Acquisition Programs
San Francisco or Lakewood or Washington or Orlando or Tampa or Atlanta or Chicago
$126k-$197k/yr OnsiteFull Time
Lead a team of Operations Research Analysts; develop reports, models, and forecasts; manage workload and provide guidance to leadership.
SQL, Excel, R, Python, SAS, Tableau
4d
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AI Engineer - Remote
United States
$110k-$150k/yr RemoteFull Time
5+ YOELead AI/ML and generative AI solutions; develop strategy; collaborate with leadership; remote US; 5+ years in enterprise AI; full-stack development; AWS AI services; GenAI; DevOps.
Python, TypeScript, Git, SQL, CI/CD, AWS, Bedrock, SageMaker, S3, Lambda, CDK, React, Vue, DevOps, AI/ML, LLM
5d
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Staff Software Engineer AI
United States
$101k-$204k/yr RemoteAll Commitments Available
7+ YOE7+ years software engineering; 3+ years leading multi-team AI initiatives; Bachelor's in CS/IS or related; strong AI/ML, software, and cloud skills; excellent collaboration.
Java, Python, Go, C++, JavaScript, REST, gRPC, Apache Kafka, Apache NiFi, Amazon SQS, MS MQ, Apache Camel, Docker, Kubernetes, AWS, Google Cloud, Azure, DevSecOps
2w
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Team Lead
United States
RemoteFull Time
ASM ResearchNYSE: ACN: Provides IT and healthcare services to government agencies.
4+ YOEBachelor's degree or equivalent; 4–7+ years Windows admin; cloud platforms (Azure/AWS); scripting (PowerShell/Python); IaC (Terraform/CloudFormation); Secret clearance; U.S. citizenship.
PowerShell, Python, Terraform, CloudFormation
2w
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Staff Software Engineer, Shopper Activation & Engagement
United States or Canada
RemoteFull Time
8+ YOE8+ yrs software engineering; 3+ yrs leading architecture; cross-functional leadership; backend proficiency; cloud; AI tooling; compliant systems design; mentoring; BS in CS/Engineering or equivalent.
Go, Java, Python, AWS, GCP, PostgreSQL, DynamoDB, Redis
1mo
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Advisory Lead, Software-TTS (SPAM)
Chicago or Boston or Dallas or Los Angeles or Minneapolis or New York City or San Francisco or Seattle or Washington D.C.
HybridFull Time
8+ YOE8-10+ years of hands-on software development; experience with complex systems integration, SDLC; Agile/Lean project management; ability to lead executive-facing engagements; strong communication.
C#, Java, Python, SDLC
3w
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Lead Instructor, Applied AI Engineering - Summer 2026
United States
$75/hr RemotePart Time, Contract
4+ YOE4+ years of full-time software development experience; strong GenAI knowledge; Python proficiency; availability for Summer 2026; teaching or mentoring experience preferred.
Python
1mo
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AI Development Lead
United States or Jupiter or New York or Arlington or Boulder or Chicago or Atlanta or Boston
$118k-$196k/yr RemoteFull Time
7+ YOE2+ MgmtSeven+ years delivering AI/software/data solutions; two+ years in leadership; hands-on Generative AI in cloud; Python with AI/LLMs; Agile/DevOps delivery; strong communication.
Python, LangChain, LangGraph, AWS, Azure, SageMaker, Bedrock, LLMs, APIs, SDKs
1mo
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Principal BI Engineer (remote)
United States
$140k-$150k/yr RemoteFull Time
5+ YOE1+ Mgmt5+ years Tableau, SQL, and Python; data modeling, semantic layer, data catalog; lead a team; Bachelor's degree strongly preferred.
Tableau, SQL, Python, Data Modeling, Semantic Layer, Data Catalog
4d
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Staff Platform Engineer AI
United States
RemoteFull Time
8+ YOE8+ years software engineering; 3+ years in tech lead/architecture/management; strong Python; cloud-native, serverless AWS; API design; AI tooling experience; excellent collaboration.
Python, AWS, API Gateway, Lambda, DynamoDB, GitHub Actions, Docker, ECS, CloudFormation, SAM, PostgreSQL, RESTful API, CI/CD
1w
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Model Validation Lead Analyst
United States
RemoteFull Time
2+ YOE2–5 years in model development or validation in financial services; proficient in Python, R, SQL; strong quantitative skills; ability to communicate with stakeholders; master's or PhD in a quantitative field.
Python, R, SQL
3w
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Staff Security Engineer
United States
RemoteFull Time
12+ YOELead design of high-performance AI data paths; 12+ yrs in storage/distributed systems; strong C/Python; GPU storage expertise; BS/ MS in CS/Engineering.
NVIDIA NIXL, GPUDirect Storage, RDMA, NVMe, Python, C/C++
2mo
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Principal Data/AI Engineer
United States
RemoteFull Time
12+ YOELead architect for scalable data pipelines and AI platforms; 12+ years in data engineering, Python/SQL, and cloud; knowledge of biotech systems and regulatory compliance.
Python, SQL, Airflow, dbt, Snowflake, AWS, Azure, Kubernetes, Docker
2mo
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Lead Decision Science Analyst (Marketing Analytics)
Oak Brook, Illinois, United States
$103k-$193k/yr HybridFull Time
5+ YOE5+ years analytics experience; strong SQL and Python; dashboard development; experimentation and causal inference; marketing/product analytics.
SQL, Python, Power BI, Tableau, Azure, Databricks, Jira
1w
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Workplace Research Lead
Chicago or Los Angeles or Arlington or San Francisco or Seattle or Boston or San Jose
OnsiteFull Time
3+ YOEPhD preferred or Master’s in I/O psychology/related field; 3+ years applied research in industry; experience with mixed methods, client-facing work, and AI tools.
Power BI, Python, R
1mo
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Principal Guidance, Navigation, & Control (GNC) Engineer
Los Angeles or United States
$190k-$260k/yr RemoteFull Time
Lead GNC architecture, perform trade studies, verification/validation, and develop GNC software and 6-DOF simulation; mentor engineers.
Python, Julia, C/C++, Matlab
HiringCafe market data
Lead Python Developer Jobs market signals in Illinois, United States
These signals come from live HiringCafe job inventory, not a static article. Use them to compare the market, then open listings above to apply directly.
Open jobs
430+
Hiring companies
260+
Fresh sample
54% new in 30d
Salary visibility
60% show pay
Companies appearing in this market
CognizantCVS HealthGuidehouseInspira FinancialOptiverWest MonroeAgiloftArize AI
Work location mix in visible results
Remote: 37Hybrid: 8Onsite: 3
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